A5045904085- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Thyroid Disorders and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Adrenal and Paraganglionic Tumors
- Neuroendocrine Tumor Research Advances
- Adrenal Hormones and Disorders
- Parathyroid Disorders and Treatments
- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Diabetes Treatment and Management
- Thyroid and Parathyroid Surgery
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer Immunotherapy and Biomarkers
- Regulation of Appetite and Obesity
- Hormonal Regulation and Hypertension
- Adipokines, Inflammation, and Metabolic Diseases
- Metabolism, Diabetes, and Cancer
- Adipose Tissue and Metabolism
- Diabetes and associated disorders
- Diabetes Management and Research
- Hormonal and reproductive studies
- Meningioma and schwannoma management
- Electrolyte and hormonal disorders
- Dialysis and Renal Disease Management
Hospital Universitario Puerta de Hierro Majadahonda
2018-2025
Universidad Autónoma de Madrid
2019-2024
Instituto de Investigación Sanitaria de Santiago
2021-2023
University of Birmingham
2022
Hospital Universitario Ramón y Cajal
2012-2021
Institut de Virologie
2021
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2019
Hospital Universitario de La Princesa
2004-2019
Instituto Cajal
2011-2018
Universidad de Alcalá
2016
Diabetes mellitus (DM) is a highly prevalent disease worldwide, estimated to affect 1 in every 11 adults; among them, 90–95% of cases are type 2 diabetes mellitus. This partly attributed the surge prevalence obesity, which has reached epidemic proportions since 2008. In these patients, cardiovascular (CV) risk stands as primary cause morbidity and mortality, placing substantial burden on healthcare systems due potential for macrovascular microvascular complications. this context, leptin, an...
We aimed to analyze the natural course of subclinical hypothyroidism, quantify incidence rate overt and evaluate risk factors for development definitive thyroid failure in elderly patients. One hundred seven patients (93 women 14 men) over age 55 yr with hypothyroidism no previous history disease were prospectively studied. Subjects followed up 6–72 months (mean, 31.7 months) repeated determinations TSH free T4. Twenty-eight (26.8%) developed 40 (37.4%) showed normalization their values. The...
In order to identify genetic factors related thyroid cancer susceptibility, we adopted a candidate gene approach. We studied tag- and putative functional SNPs in genes involved cell differentiation proliferation, found be differentially expressed carcinoma. A total of 768 97 were genotyped Spanish series 615 cases 525 controls, the former comprising largest collection patients with this pathology from single population date. an LD block spanning entire FOXE1 showed strongest evidence...
Aim: Assess the prevalence of thyroid dysfunction in patients with type 2 diabetes (T2D) Segovia (Spain).
Pituitary apoplexy (PA) is an acute, life-threatening clinical syndrome caused by hemorrhage and/or infarction of the pituitary gland. It clinically characterized sudden onset headache. Depending on severity, it may also be accompanied nausea, vomiting, visual disturbances, varying degrees adenohypophyseal hormone deficiency, and decreased level consciousness. Corticotropic axis involvement result in severe hypotension contribute to impaired Precipitating factors are present up 30% cases. PA...
Adipose tissue is a hormonally active system that produces and releases different bioactive substances. Leptin, adiponectin resistin are some of the recently discovered adipocytokines participate in regulation intermediate metabolism. The aim this study was to evaluate circulating levels leptin, patients with thyroid dysfunction before after normalization function appropriate therapy.We studied 20 hyperthyroidism (16 women 4 men; mean age 47.2 +/- 3.9 years) hypothyroidism (17 3 51.5 4.1...
Summary Background and Objective High levels of some adipocytokines have been reported in patients with chronic renal failure, but little information is available on adipocytokine concentrations uraemic under different modalities therapy. Our aims were (1) to quantify the serum leptin, adiponectin resistin peritoneal dialysis (PD) haemodialysis (HD), comparison conservative management, (2) study relationships between previous atherosclerotic vascular disease. Patients Measurements We studied...
Patients with subclinical hypothyroidism may revert to normal TSH values.The objective of this study was examine the time course normalization levels in hypothyroidism.This a prospective, observational no intervention, duration follow-up 12-72 months.Outpatients visited an endocrinology clinic general hospital.Forty patients (32 women, mean age 62.8 +/- 8.2 yr) spontaneous (TSH > 5 mU/liter and free T(4)) participated study. Each patient normalized their values without T(4) therapy...
Few data exist about the clinical course of acromegaly, surgical and medical outcomes in patients with GH- prolactin cosecreting pituitary adenomas (GH&PRL-PAs). Nevertheless, some series described a more aggressive clinic-radiological behavior than growth hormone-secreting (GH-PAs).
Diabet. Med. 29, 1510–1514 (2012) Abstract Aims We aimed to assess the relative risk for hypothyroidism in patients with Type 2 diabetes. Methods In this study, 1112 diabetes (58% women, mean age 66.7 years, median duration of 10 179 previous history thyroid disease) and 911 subjects without were evaluated. Results The gender‐, age‐ weight‐adjusted (odds ratio) newly identified comparison control was 2.81 (1.77–4.48). This odds ratio significant over 65 years [4.02 (1.95–8.31)], as well both...
To evaluate serum levels of osteocalcin (OC), procollagen type 1 N-terminal propeptide (P1PN) and beta-CrossLaps (beta-CTx) in obese subjects their relationship with glucose metabolism parameters.Sixty-four patients classified according to tolerance.Case-control study.A 75-g oral tolerance test was performed determinations insulin between 0 120 min. Serum concentrations OC, P1PN beta-CTx were quantified baseline samples.Patients 2 diabetes (T2D, n = 24) exhibited OC (2·6 ± 1·0 nm)...