A5012145074- Blood properties and coagulation
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Treatment and Management
- Adipose Tissue and Metabolism
- Diabetes Management and Research
- Diabetes and associated disorders
- Mitochondrial Function and Pathology
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Lipid metabolism and disorders
- Metabolism and Genetic Disorders
- Lipoproteins and Cardiovascular Health
- Regulation of Appetite and Obesity
- Endoplasmic Reticulum Stress and Disease
- Nutrition and Health in Aging
- Antioxidant Activity and Oxidative Stress
- Autophagy in Disease and Therapy
- Metabolism, Diabetes, and Cancer
- Inflammatory Biomarkers in Disease Prognosis
- Advanced Glycation End Products research
- Blood Coagulation and Thrombosis Mechanisms
- Thyroid Disorders and Treatments
- Iron Metabolism and Disorders
- Apelin-related biomedical research
Hospital Universitario Doctor Peset
2015-2024
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
2013-2024
Universitat de València
2002-2023
Hospital Universitario de La Princesa
2019
INCLIVA Health Research Institute
2012-2015
Type 2 diabetes (T2D) is linked to metabolic, mitochondrial and inflammatory alterations, atherosclerosis development cardiovascular diseases (CVDs). The aim was investigate the potential therapeutic benefits of GLP-1 receptor agonists (GLP-1 RA) on oxidative stress, respiration, leukocyte-endothelial interactions, inflammation carotid intima–media thickness (CIMT) in T2D patients. diabetic patients (255) control subjects (175) were recruited, paired by age sex, separated into two groups:...
Context: Insulin resistance is a feature of polycystic ovary syndrome (PCOS) and related to mitochondrial function.
The association between morbid obesity and hyperhomocysteinemia (HH) remains controversial the nature of this relationship needs to be clarified as several metabolic, lipidic, inflammatory anthropometric alterations that accompany may involved. In 66 morbidly obese patients, 47 women 19 men aged 41 ± 12 years normo-weight subjects, 43 23 men, 45 11 years, we determined homocysteine (Hcy) levels along with anthropometric, insulin resistance markers. addition, investigated effect Metabolic...
The contribution of hemorheological alterations in the prothrombotic condition patients with metabolic syndrome (MS) remains a question debate. We aimed to determine association between MS and parameters by means case-c
Mitochondrial dysfunction has been shown to play a central role in the pathophysiology of type 2 diabetes (T2D), and mitochondria-targeted agents such as SS-31 are emerging promising strategy for its treatment. We aimed study effects on leukocytes from T2D patients by evaluating oxidative stress, endoplasmic reticulum (ER) stress autophagy. Sixty-one 53 controls were included. Anthropometric analytical measurements performed. also assessed reactive oxygen species (ROS) production, calcium...
Circulating C3 levels are elevated in obese patients, but how this factor is affected after weight loss through diet a question that yet unanswered. Therefore, the aim of study was to evaluate effects on lipid and hydrocarbonated metabolism parameters C4 components complement patients.This longitudinal intervention based 6-week very low-calorie (VLCD), liquid formula 603 kcal/day. A total 131 middle-aged patients were distributed among grades II, III IV obesity. Anthropometric parameters,...
Subclinical hypothyroidism (SCH) is a common condition associated with increased cardiovascular risk. A standard treatment yet to be established, as there no consensus on the TSH cut-off values which should used indicators. Thus, aim of this study was assess risk in patients SCH and differentiate it according levels.This an observational conducted academic medical centre.The population consisted 95 middle-aged women recently diagnosed 65 euthyroid controls.We measured anthropometric...
Retinol binding protein 4 (RBP4) is an adipokine that may contribute to the development of insulin resistance. However, how this affected and its possible involvement in lipid metabolism obese patients with varying degrees resistance yet be determined. A total 299 middle-aged morbid (BMI>40 kg/m2) were divided euglycemic, metabolic syndrome or type 2 diabetic. Anthropometric measurements, biochemical variables systemic RBP4 levels significantly higher diabetes than euglycemic subjects...
Increased red blood distribution width (RDW) in anemia is related to disturbances the cellular surface/volume ratio, usually accompanied by morphological alterations, while it has been shown inflammatory diseases that activity of pro-inflammatory cytokines disturbing erythropoiesis increa ses RDW. Recently reported higher RDW with decreased erythrocyte deformability, and could be association increased risk cardiovascular diseases. In order analyze influence alterations proinflammatory status...
Since type 2 diabetes (T2D) is associated with oxidative stress and metformin has been shown to exert a protective role against the said stress, we wondered whether treatment might also modulate endoplasmic reticulum (ER) autophagy in leukocytes of T2D patients. We studied 53 patients (37 whom had treated 1700 mg for at least 1 year) 30 healthy volunteers. Leukocytes from both groups exhibited increased protein levels 78-kDa glucose-regulated (GRP78) respect controls, whereas activating...
Since mitochondrial dysfunction is associated with NOD-like receptor family protein 3 (NLRP3) activation in type 2 diabetes (T2D), which can eventually lead to an impaired immune response, we set out determine if glycemic control modulates the effects of T2D on NLRP3 inflammasome. We have studied leukocytes from 61 diabetic patients [25 glycated hemoglobin (HbA1c) ≤7% and 36 HbA1c ≥8%] 40 healthy controls. Total reactive oxygen species (ROS) production was enhanced patients, ROS more...
Sodium-glucose co-transporter 2 inhibitors (iSGLT2) have been linked to cardiovascular risk reduction in patients with type diabetes (T2D). However, their underlying molecular mechanisms remain unclear. This study aimed evaluate the effects of empagliflozin, a novel potent and selective iSGLT-2, on anthropometric endocrine parameters, leukocyte–endothelium interactions, adhesion molecules, ROS production, NFkB-p65 transcription factor expression. According standard clinical protocols,...
It has been suggested that increased erythrocyte membrane phosphatidylserine (PS) exposure could contribute to hypercoagulability and hemorheological disturbances in obesity. The aim of our study was evaluate PS obese patients a control group correlate this with properties, i.e., aggregability (EA) deformability, the effect weight loss on these parameters. An anthropometric analytical evaluation performed at baseline after 3 months diet (very low-calorie for 4 weeks 2 months) 49 severe or...
There are few studies on haemorheological disturbances in morbidly obese patients. The role played by the metabolic syndrome rheological profile of subjects has not yet been established, and it is clear whether obese, but "metabolically healthy", show alterations. We aimed to determine whole 136 patients normo-weight volunteers, along with plasma lipids, inflammatory insulin resistance parameters. Patients had statistically higher glucose, triglycerides, HbA1c, leptin, insulin, HOMA, CRP,...