A5055401352- Gastrointestinal motility and disorders
- Gastroesophageal reflux and treatments
- Infant Health and Development
- Heart Rate Variability and Autonomic Control
- Diet and metabolism studies
- Congenital gastrointestinal and neural anomalies
- Gastric Cancer Management and Outcomes
- Pelvic floor disorders treatments
- Helicobacter pylori-related gastroenterology studies
- Neuropeptides and Animal Physiology
- Colorectal Cancer Treatments and Studies
- Traditional Chinese Medicine Studies
- Phonocardiography and Auscultation Techniques
- Advanced Numerical Analysis Techniques
- Anorectal Disease Treatments and Outcomes
- Cancer Diagnosis and Treatment
- Manufacturing Process and Optimization
- Cardiovascular Syncope and Autonomic Disorders
- Ion Transport and Channel Regulation
- Dysphagia Assessment and Management
- Light effects on plants
- Forest, Soil, and Plant Ecology in China
- Ion Channels and Receptors
- Optical measurement and interference techniques
- Animal Nutrition and Physiology
McMaster University
2015-2025
Population Health Research Institute
2014-2024
Shenzhen Bao'an District People's Hospital
2022
Huazhong University of Science and Technology
1997-2021
Nanjing University of Chinese Medicine
2013-2020
Jiangsu Province Hospital
2015-2020
Alnylam Pharmaceuticals (United States)
2020
Shanghai Maritime University
2018
Xi’an International University
2018
Astellas Pharma (United States)
2016-2018
Building cyber-physical system (CPS) models of machine tools is a key technology for intelligent manufacturing. The massive electronic data from computer numerical control (CNC) during the work processes CNC tool main source big on which CPS model established. In this work-process model, method based instruction domain applied to analyze data, and quantitative description (NC) built according G code processes. Utilizing domain, established basis accurate, real-time mapping manufacturing...
Background and Aims Better understanding of intrinsic control mechanisms colonic motility will lead to better treatment options for dysmotility. The aim was investigate neurogenic myogenic underlying pan-colonic motor patterns. Methods Analysis in vitro video recordings whole rat colon used explore patterns their spatiotemporal organizations identify using pharmacological tools. Results Study the organization revealed: fluid-induced or spontaneous rhythmic propulsive long distance...
Simultaneous pressure waves (SPWs) in manometry recordings of the human colon have been associated with gas expulsion. Our hypothesis was that SPW might be a critical component most colonic motor functions, and hence act as biomarker for healthy motility. To end, we performed high-resolution (HRCM), first time using an 84-sensor (1 cm spaced) water-perfused catheter, 17 volunteers. Intraluminal patterns were recorded during baseline, proximal rectal balloon distention, after meal following...
Traditional Chinese medicine (TCM) has long been used to treat chronic kidney disease (CKD) in Asia. Its effectiveness and safety for CKD treatment have confirmed documented studies. However, the prescription rule of formulae medicinal herbs is complicated remains uncharacterized. Thus, we data mining technology evaluate principle coprescription pattern these TCM treatment.Data on patients with were obtained from outpatient system a hospital. We established herb knowledge base based...
Patisiran, an RNA interference therapeutic, has demonstrated robust reduction of wild-type and mutant transthyretin protein was able to improve polyneuropathy quality life following 18 months treatment in patients with hereditary transthyretin-mediated (hATTR) amyloidosis. In this 24-month Phase II open-label extension study, we evaluated the effects patisiran (0.3 mg/kg intravenously every 3 weeks) on safety, serum levels, clinical parameters. Efficacy assessments included modified...
Characterization of high-amplitude propagating pressure waves (HAPWs or HAPCs) plays a key role in diagnosis colon dysmotility using any type colonic manometry. With the introduction high-resolution manometry, more insight is gained into this most prominent propulsive motor pattern. Here, we use water-perfused catheter with 84 sensors intervals between measuring points 1 cm throughout colon, for 6–8 h, 19 healthy subjects. The contained balloon to evoke distention. We explored as stimuli...
Abstract Background High‐resolution colonic manometry gives an unprecedented window into motor patterns of the human colon. Our objective was to characterize activities throughout entire colon that possessed persistent rhythmicity and spanning at least 5 cm. Methods using 84‐channel water‐perfused catheter performed in 19 healthy volunteers. Rhythmic activity assessed during baseline, proximal balloon distention, meal, bisacodyl administration. Key Results Throughout colon, a cyclic pattern...
The parameters of heart rate variability (HRV) can non-invasively assess some autonomic activities, and HRV is influenced by many bodily actions. Although parasympathetic activity the primary driver colonic propulsive activity, sympathetic a major inhibitor motility, they are rarely measured almost play no role in diagnosis colon motor dysfunction or standard treatments. Here we set out to optimize analysis nervous system changes related human motility. electrocardiogram impedance were...
The extrinsic autonomic nervous system is critical in controlling most organ functions and involved the pathophysiology of many chronic diseases. However, its assessment plays a minor role clinical practice diagnosis treatment outside cardiology. Since sympathetic dysfunction related to diseases such as diabetes, stress, urinary gastrointestinal motor dysfunction, an warranted. Here, we evaluate Baevsky Stress Index (SI) assess tone reactivity based on heart rate variability. We start with...
Phase-amplitude coupling of two pacemaker activities the small intestine, omnipresent slow wave activity generated by interstitial cells Cajal myenteric plexus (ICC-MP) and stimulus-dependent rhythmic transient depolarizations ICC deep muscular (ICC-DMP), was recently hypothesized to underlie orchestration segmentation motor pattern. The aim present study increase our understanding phase-amplitude through modeling. In particular importance propagation velocity ICC-DMP component investigated....
The quest to understand the pathophysiology of autism spectrum disorder (ASD) has led extensive literature that purports provide evidence for autonomic dysfunction based on heart rate and variability (HRV), in particular respiratory sinus arrhythmia (RSA), a measure parasympathetic functioning. Many studies conclude is associated with vagal withdrawal sympathetic hyperactivation HRV electrodermal analyses. We will argue critical analysis data leads hypothesis nervous system not dominant...
Abstract Background Interstitial cells of Cajal associated with the submuscular plexus ( ICC ‐ SMP ) generate omnipresent slow‐wave activity in colon and are prominent motor patterns. Our aim was to investigate dysfunction W/W v mice which reportedly reduced. Methods Whole organ motility studied using spatio‐temporal mapping; immunohistochemical staining carried out for c‐Kit Ano1; calcium imaging applied . Key Results Discrepancies between Ano1 were found both wild‐type colon. reduced ~50%...
Tivozanib, a selective inhibitor of VEGFR-1, -2, and -3, plus mFOLFOX6 in an advanced gastrointestinal cancer phase Ib study had encouraging antineoplastic activity tolerable safety profile. This randomized, open-label, II trial tivozanib/mFOLFOX6 versus bevacizumab/mFOLFOX6 patients with previously untreated metastatic colorectal (mCRC) evaluated tivozanib bevacizumab.Treatment-naïve received every 2 weeks each 28-day cycle either orally 1.5 mg once daily for 21 days or bevacizumab...
Abnormal colonic motility may be associated with dysfunction of the autonomic nervous system (ANS). Our aim was to evaluate if associations between motor patterns and neural activity could demonstrated by assessing changes in heart rate variability (HRV) healthy volunteers. A total 145 were assessed 11 volunteers High-Resolution Colonic Manometry (HRCM) using an 84-channel water-perfused catheter. Motor evoked balloon distention, a meal luminal bisacodyl. The electrocardiogram (ECG) cardiac...
Here, we present the first full characterization and quantification of motor patterns that infer to be confined single haustra, both intrahaustral activity haustral boundary activity, in human colon using high-resolution manometry. Haustral is intermittent but consistently about half haustra. Intrahaustral presents as a cyclic pattern mixed propagation direction dominated by simultaneous pressure waves can resolve into checkerboard segmentation, allowing for mixing, absorption, stool formation.
We report the first study assessing human colon manometric features and their correlations with changes in autonomic functioning patients refractory chronic constipation prior to consideration of surgical intervention. High-resolution colonic manometry (HRCM) simultaneous heart rate variability (HRV) was performed 14 patients, resulting were compared healthy subjects. Patients categorized into three groups that had normal, weak, or no high amplitude propagating pressure waves (HAPWs) any...
Deep breathing exercises are the second most used complementary health approach in United States. Two heart rate variability (HRV) parameters, root mean square of successive differences (RMSSD) and respiratory sinus arrhythmia (RSA), to assess parasympathetic reactivity deep breathing, but they often not agreement. Our purpose was determine cause disagreement. We investigated HRV parameters 38 subjects during baseline, recovery. Here we show that RMSSD as a measure is unreliable; it does...
OPINION article Front. Neurosci., 01 April 2013Sec. Autonomic Neuroscience https://doi.org/10.3389/fnins.2013.00043