A5076969370- Cardiovascular Disease and Adiposity
- Extracellular vesicles in disease
- Cardiovascular Effects of Exercise
- Diabetes Treatment and Management
- Cardiovascular Function and Risk Factors
- Cardiac Fibrosis and Remodeling
- Cardiac Valve Diseases and Treatments
- Elbow and Forearm Trauma Treatment
- Orthopedic Surgery and Rehabilitation
- Peptidase Inhibition and Analysis
- Infective Endocarditis Diagnosis and Management
- Rheumatoid Arthritis Research and Therapies
- Pancreatic function and diabetes
- Peripheral Nerve Disorders
- Adenosine and Purinergic Signaling
- Adipose Tissue and Metabolism
- Cardiac pacing and defibrillation studies
- Cardiac Structural Anomalies and Repair
Rhode Island Hospital
2022-2024
Brown University
2022-2024
University Hospitals of North Midlands NHS Trust
2022
Background Sodium-glucose cotransporter-2 inhibitors are cardioprotective independent of glucose control, as demonstrated in animal models acute myocardial ischemia and clinical trials. The functional molecular mechanisms these benefits the setting chronic poorly defined. purpose this study is to determine effects canagliflozin therapy on perfusion, fibrosis, function a large model ischemia. Methods Results Yorkshire swine underwent placement an ameroid constrictor left circumflex artery...
ObjectiveLimited treatments exist for nonoperative chronic coronary artery disease. Previously, our laboratory has investigated extracellular vesicle (EV) therapy as a potential treatment disease using swine model and demonstrated improved cardiac function in treated with intramyocardial EV injection. Here, we seek to investigate the benefits of EVs by hypoxia-conditioned (HEV). Specifically, this study aims effect HEV on apoptosis chronically ischemic myocardium swine.MethodsFourteen...
We have previously shown that normoxia serum-starved extracellular vesicle (EV) therapy improves myocardial function, perfusion, and angiogenesis in a swine model of chronic ischemia. Hypoxia-modified EVs increased abundance anti-oxidant, pro-angiogenic, pro-survival proteins. The purpose this study is to investigate the differential effects hypoxia-modified on microvascular density chronically ischemic myocardium. Yorkshire underwent placement an ameroid constrictor left circumflex artery...
Introduction: Patients with advanced coronary artery disease (CAD) who are not eligible for stenting or surgical bypass procedures have limited treatment options. Extracellular vesicles (EVs) emerged as a potential therapeutic target the of CAD. These EVs can be conditioned to modify their contents. In our previous research, we demonstrated increased perfusion, decreased inflammation, and reduced apoptosis intramyocardial injection hypoxia-conditioned (HEVs). The goal this study is further...
Coronary artery disease remains a leading cause of morbidity and mortality worldwide. Patients with advanced coronary who are not eligible for endovascular or surgical revascularization have limited options. Extracellular vesicles shown potential to improve myocardial function in preclinical models. can be conditioned modify their components. Hypoxia-conditioned extracellular demonstrated the ability reduce infarct size apoptosis small animals. Our objective is assess benefits...
Objective Although both clinical data and animal models suggest cardiovascular benefits following administration of Dipeptidyl Peptidase 4 (DPP-4) inhibitors, the underlying mechanisms remain unclear. We therefore sought to evaluate effect DPP-4 inhibitor sitagliptin on myocardial fibrosis, insulin signaling in chronic ischemia using a swine model. An ameroid constrictor placement left coronary circumflex artery thirteen Yorkshire model ischemia. After two weeks recovery, were assigned one...
Introduction: The effect of obesogenic diet on the outcomes coronary artery disease are controversial with some clinical studies suggesting a paradoxical favorable obesity. We seek to better understand effects high-fat chronic myocardial ischemia using swine model and Proteomic Analysis. Methods: Twenty 6-week-old Yorkshire received 5 weeks normal (n=9, ND) or (n=11, HFD) prior placement an ameroid constrictor left circumflex induce ischemia. continued ND HFD for seven after procedure. At...
Introduction: Percutaneous balloon mitral valvuloplasty (PBMV) is primarily performed for rheumatic stenosis (MS). Therefore, limited data exist on PBMV in countries with a low incidence of disease. We sought to examine in-hospital and readmission outcomes the U.S. Methods: Using Nationwide Readmission Database, hospitalizations which patients received non-rheumatic MS were identified. In-hospital mortality 30-day rate examined, multivariable logistic regression was risk adjustment....