A5004030059- Virology and Viral Diseases
- Vector-Borne Animal Diseases
- Paraoxonase enzyme and polymorphisms
- Thermal Analysis in Power Transmission
- T-cell and B-cell Immunology
- Lightning and Electromagnetic Phenomena
- Pancreatic function and diabetes
- Advanced Combustion Engine Technologies
- Herpesvirus Infections and Treatments
- Immune Cell Function and Interaction
- Neuroinflammation and Neurodegeneration Mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Angiogenesis and VEGF in Cancer
- Microbial infections and disease research
- Insect and Pesticide Research
- Animal Virus Infections Studies
- Immune Response and Inflammation
- Advanced Control Systems Optimization
- Complement system in diseases
- Power Transformer Diagnostics and Insulation
- Viral Infections and Vectors
- Biodiesel Production and Applications
- Coccidia and coccidiosis research
- Fault Detection and Control Systems
National Kyushu Medical Center
2020-2024
Takeda (Japan)
2024
Kyoto University
2023
ETH Zurich
2020-2021
Czech Academy of Sciences, Institute of Microbiology
2020
Toyota Motor Corporation (Japan)
2010-2019
Toyota Central Research and Development Laboratories (Japan)
2019
Toyota Motor Corporation (Switzerland)
2008-2019
Analysis Group (United States)
2019
Konica Minolta (Japan)
2019
Nonvolatile memories with fast write operation at low voltage are required as storage devices to exceed flash memory performance. We develop an 8Mb multi-layered cross-point ReRAM macro 443MB/S throughput (64b parallel per 17.2ns cycle), which is almost twice existing methods, using the fast-switching performance of TaOχ and following three techniques reduce sneak current in bipolar type cell array structure 0.18μm process. First, technologies a newly developed bidirectional diode select...
Variable cDNA regions in the VP2 gene of five highly virulent infectious bursal disease viruses (IBDVs) isolated Japan were amplified by polymerase chain reaction (PCR) and sequenced. The nucleotide sequences IBDVs identical. Comparisons deduced amino acid with those other strains IBDV indicated that Japanese is different from all compared. number acids differed between (substitution score) showed more closely related to European strain 52/70 than conventional strains. These results strongly...
To examine the clinical significance of insulin resistance index as determined by homeostasis model assessment (HOMA-IR), we investigated relationship between HOMA-IR and estimated euglycemic-hyperinsulinemic clamp method in various subgroups compared with that fasting plasma levels (FIRI). was significantly correlated to inverse glucose infusion rate (1/GIR) both diabetic non-diabetic subjects (r=0.747, P<0.0001 r=0.419, P<0.002, respectively). In patients, treatment sulfonylureas did not...
Intestinal epithelial cell (IEC) NF-κB signaling regulates the balance between mucosal homeostasis and inflammation. It is not fully understood which signals tune this how bacterial exposure elicits process. Pure LPS induces activation in vivo. However, we found that mice, IECs do respond directly to LPS. Instead, tissue-resident lamina propria intercrypt macrophages sense via TLR4 rapidly secrete TNF elicit their immediate neighborhood. This response pattern relevant also during oral...
A 36-year-old woman with positional headache was found to have primary low cerebrospinal fluid (CSF) pressure syndrome and galactorrhea. The CSF at lumbar puncture not measurable. Magnetic resonance imaging demonstrated that the ventricle cerebral sulcus were narrowed pituitary stalk oppressed by brain. Hyperresponsiveness of prolactin noted after stimulation thyrotropin-releasing hormone. These abnormalities disappeared normalization treatment. Galactorrhea apparently due oppression...
The immunosuppressive effect of infectious bursal disease virus (IBDV) on vaccination against Newcastle (ND) was compared among 2-, 3-, and 4-week-old chickens inoculated with the highly virulent IBDV field isolate 90-11 reference serotype 1 strain GBF-1. In all age groups, severely suppressed antibody response to ND protective vaccinal immunity ND. contrast, GBF-1 vaccinated vaccine were well protected from challenge. mitogenic phytohemagglutinin splenic lymphocytes or significantly lower...
We report a 49-year-old woman with severe diabetic scleredema (DS). The patient had noninsulin-dependent diabetes mellitus (NIDDM) for 9 years and noticed thickened skin on her back 3 previously. Her DS rapidly extended to extremities pain immobility. symptoms of improved dramatically after establishing strict glycemic control intravenous administration prostaglandin E1 (PGE1). However, the histological findings biopsy did not change even treatment 12 weeks, worsened again discontinuation...
Cardiac death from atherosclerosis is common in hemodialysis patients. Human serum paraoxonase (PON1), an esterase, associated with high-density lipoprotein and inhibits the susceptibility to oxidization of low-density (LDL). The PON1 genetic polymorphisms 192 Gln/Arg 55 Leu/Met amino acid sequence are partly involved enzyme activity. We investigated activities for paraoxon (paraoxonase) phenylacetate (arylesterase), two 96 patients undergoing 136 normal controls. Both were significantly...
For pluripotent stem cell (PSC)-based regenerative therapy against diabetes, the differentiation efficiency to pancreatic lineage cells needs be improved based on mechanistic understanding of differentiation. Here, we aimed elucidate molecular mechanisms underlying endoderm by searching for factors that regulate a crucial marker gene, NKX6.1. Unbiasedly screening an siRNA knockdown library, identified candidate transcription factor, HHEX. HHEX suppressed expression another PTF1A, as well...
The pathogenesis of highly virulent infectious bursal disease (IBD) virus (IBDV) infection was studied using 6-week-old intact and 5-week-old bursectomized chickens inoculated with strain 90-11 or reference I. Chickens 100.7EID50 showed neither clinical signs nor lesions during the 4-day observation period. In contrast, birds 102.7 104.7EID50 developed severe IBD, as well gross histologic lesions, typical produced IBDV antigen demonstrable by immunostaining in bursa Fabricius (BF), thymus,...