A5071320926- Prostate Cancer Treatment and Research
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- Cancer-related Molecular Pathways
- Cancer Genomics and Diagnostics
- DNA Repair Mechanisms
- Radiopharmaceutical Chemistry and Applications
- Immunotherapy and Immune Responses
- Cell Adhesion Molecules Research
- Ferroptosis and cancer prognosis
- Cancer Research and Treatments
- PARP inhibition in cancer therapy
- Bone health and treatments
- Cancer-related gene regulation
- Smart Grid and Power Systems
- Energy Load and Power Forecasting
- HER2/EGFR in Cancer Research
- Cancer-related molecular mechanisms research
- Advanced Breast Cancer Therapies
- Bioinformatics and Genomic Networks
- Cancer therapeutics and mechanisms
- Hydraulic flow and structures
- Advanced Image Fusion Techniques
- Power Line Inspection Robots
- Remote-Sensing Image Classification
East China Normal University
2014-2024
Thomas Jefferson University
2013-2019
Sidney Kimmel Cancer Center
2013-2016
Sichuan University
2007-2014
State Key Laboratory of Hydraulics and Mountain River Engineering
2011
China University of Geosciences (Beijing)
2010
Abstract Src family kinases (SFK) integrate signal transduction for multiple receptors, regulating cellular proliferation, invasion, and metastasis in human cancer. Although is rarely mutated prostate cancer, SFK activity increased the majority of cancers. To determine molecular mechanisms governing cancer bone metastasis, FVB murine epithelium was transduced with oncogenic v-Src. The cell lines metastasized mice to brain bone. Gene expression profiling tumors identified activation a CCR5...
Abstract Improved clinical management of prostate cancer has been impeded by an inadequate understanding molecular genetic elements governing tumor progression. Gene signatures have provided improved prognostic indicators human cancer. The TGF-β/BMP-SMAD4 signaling pathway, which induces epithelial–mesenchymal transition (EMT), is known to constrain progression induced Pten deletion. Herein, cyclin D1 inactivation reduced cellular proliferation in the murine vivo and isogenic...
Abstract Prostate cancer is the second leading form of cancer-related death in men. In a subset prostate patients, increased chemokine signaling IL8 and IL6 correlates with castrate-resistant (CRPC). are produced by epithelial cells promote cell invasion; however, mechanisms restraining cytokine secretion poorly understood. Herein, cell-fate determinant factor DACH1 inhibited CRPC tumor growth mice. Using Dach1fl/fl/Probasin-Cre bitransgenic mice, we show was altered approximately 1,000-fold...
Proteomic analysis of castration-resistant prostate cancer demonstrated the enrichment Src tyrosine kinase activity in approximately 90% patients. is known to induce cyclin D1, and a D1-regulated gene expression module predicts poor outcome human cancer. The tumor-associated calcium signal transducer 2 (TACSTD2/Trop2/M1S1) enriched prostate, promoting stem cell self-renewal upon proteolytic activation via γ-secretase cleavage complex (PS1, PS2) TACE (ADAM17), which releases Trop2...
Lysine methylation of histones and non-histone substrates by the SET domain containing protein lysine methyltransferase (KMT) G9a/EHMT2 governs transcription contributing to apoptosis, aberrant cell growth, pluripotency. The positioning chromosomes within nuclear three-dimensional space involves interactions between lamina (NL) lamina-associated domains (LAD). Contact individual LADs with NL are dependent upon H3K9me2 introduced G9a. mechanisms governing recruitment G9a distinct subcellular...
Abstract Power system dispatch benefits from accurate wind power predictions. To increase the prediction precision for power, this paper proposes a combined model predicting short-term based on autoregressive moving average-gated recurrent unit (ARMA-GRU). Firstly, we build ARMA and GRU respectively to predict power. Then optimize model’s weights by quantum particle swarm algorithm (QPSO). Finally, an error correction errors acquire final results Our experimental prove reliability high...
When there are inherent disturbances or noise in the system inputs that impossible impractical to remove, various forms of feedback and feedforward adjustment have been used Statistic Process Control (SPC). This article presents a general control framework analysis compensate for deviations quality characteristic.
Abstract The T-RBAC model has a wide range of applications in various fields, but certain disadvantages. Aiming at the shortcomings task assignment and authority management, an improved is proposed. new simplifies classification model. Considering context, time limit, status attributes, role manager, manager are introduced, grant closely linked with three managers, which enhances dynamic management rights. constraints strengthened expanded to ensure separation duties during execution....
The fusion of infrared images and visible can enrich image information obtain high-quality target in complex environments. It has a wide range applications detection, enhancement other fields. To solve the problems existing current deep learning-based methods that network cannot fully extract features source is not retained, this paper proposes structure based on residual compression decomposition network. Firstly, self-encoder used to features, fuse reconstruct from two more effective...
With the continuous development of state grid, power transmission equipment is also increasing, and how to efficiently inspect maintain has become a key concern in industry. In order reduce consumption manpower inspection process, current method mainly send drones take patrol photos then use deep learning identify faulty equipment. However, actual generally built areas with more natural vegetation, so pictures obtained from have problems such as unclear targets too many irrelevant areas,...
<p>Supplemental Figure 1. Quantitation and statistical evaluation of the microarray data for Fig. 1A 2H, I. Supplemental 2. Somatic excision Dach1 in prostate epithelial cells. 3. Transgenic deletion cells enhances cellular proliferation reduces apoptosis. 4. Prostate specific expression cyclin D1 A1. 5. 3F 4A, B. 6. ChIP analysis A2 E1 promoter regions. 7. Endogenous is a key restraint cytokine production. 8. Time lapse microscopy Dach1-/- vs. Dach1+/+ anterior 9. increases IL-6 IL-8...
Supplemental Figure Legend from The Endogenous Cell-Fate Factor Dachshund Restrains Prostate Epithelial Cell Migration via Repression of Cytokine Secretion a CXCL Signaling Module
Supplemental Figure Legend from The Endogenous Cell-Fate Factor Dachshund Restrains Prostate Epithelial Cell Migration via Repression of Cytokine Secretion a CXCL Signaling Module
<div>Abstract<p>Prostate cancer is the second leading form of cancer-related death in men. In a subset prostate patients, increased chemokine signaling IL8 and IL6 correlates with castrate-resistant (CRPC). are produced by epithelial cells promote cell invasion; however, mechanisms restraining cytokine secretion poorly understood. Herein, cell-fate determinant factor DACH1 inhibited CRPC tumor growth mice. Using <i>Dach1<sup>fl/fl</sup></i>/Probasin-Cre...
<div>Abstract<p>Prostate cancer is the second leading form of cancer-related death in men. In a subset prostate patients, increased chemokine signaling IL8 and IL6 correlates with castrate-resistant (CRPC). are produced by epithelial cells promote cell invasion; however, mechanisms restraining cytokine secretion poorly understood. Herein, cell-fate determinant factor DACH1 inhibited CRPC tumor growth mice. Using <i>Dach1<sup>fl/fl</sup></i>/Probasin-Cre...
<p>Supplemental Figure 1. Quantitation and statistical evaluation of the microarray data for Fig. 1A 2H, I. Supplemental 2. Somatic excision Dach1 in prostate epithelial cells. 3. Transgenic deletion cells enhances cellular proliferation reduces apoptosis. 4. Prostate specific expression cyclin D1 A1. 5. 3F 4A, B. 6. ChIP analysis A2 E1 promoter regions. 7. Endogenous is a key restraint cytokine production. 8. Time lapse microscopy Dach1-/- vs. Dach1+/+ anterior 9. increases IL-6 IL-8...
<p>PDF file - 124K</p>
<p>PDF file - 107K, Cyclin D1 expression signature is induced in prostatospheres and induction of Wnt.</p>
<p>Supplemental Figures S1-S12. Supplement 1. High resolution images of normal prostate and v-Src-PEC tumor 2. AR, CK5 CK8 abundances in cultured v-Src-PECs compared with primary PECs detected by western-blot. 3. bone metastasis adjacent marrow 4. Kegg-pathway analysis up-regulated genes vs 5. gene expression profile comparing FVB murine epithelial cells 6. Validation CCR5 qtPCR tumors derived subcutaneous injection 7. public available database 8. FACS positive population 9. image...