A5034170310- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Viral Infectious Diseases and Gene Expression in Insects
- vaccines and immunoinformatics approaches
- Virus-based gene therapy research
Technical University of Munich
2021-2024
Klinikum rechts der Isar
2021-2022
München Klinik
2022
Neoantigens derived from somatic mutations correlate with therapeutic responses mediated by treatment immune checkpoint inhibitors. are therefore highly attractive targets for the development of approaches in personalized medicine, although many aspects their quality and associated not yet well understood. In a case study metastatic malignant melanoma, we aimed to perform an in-depth characterization neoantigens respective T-cell context modulation. Three neoantigens, which identified either...
Abstract Neoantigen-specific T cell receptors (neoTCRs) promise safe, personalized anti-tumor immunotherapy. However, detailed assessment of neoTCR-characteristics affecting therapeutic efficacy is mostly missing. Previously, we identified diverse neoTCRs restricted to different neoantigens in a melanoma patient. In this work, now combine single-cell TCR-sequencing and RNA-sequencing after neoantigen-specific restimulation peripheral blood-derived CD8 + cells We detect with specificity for...
Abstract Neoantigens derived from somatic mutations have been demonstrated to correlate with therapeutic responses mediated by treatment immune checkpoint inhibitors. are therefore highly attractive targets for the development of personalized medicine approaches although their quality and associated is not yet well understood. In a case study metastatic malignant melanoma, we performed an in-depth characterization neoantigens respective T-cell in context immunotherapy Ipilimumab. Three...
Abstract Neoantigen-specific T cell receptors (neoTCRs) promise a safe, highly personalized therapeutic approach in anti-tumor immunotherapy. Substantial progress has been made regarding their identification whereas detailed functional assessment of single TCR characteristics impacting efficacy is lacking. We previously identified and functionally characterized neoTCRs specific for neoepitopes derived from KIF2C SYTL4 demonstrating differences avidity patient with metastatic melanoma. In...