A5009530576- Advanced Sensor and Energy Harvesting Materials
- Force Microscopy Techniques and Applications
- Biosensors and Analytical Detection
- thermodynamics and calorimetric analyses
- Electrochemical sensors and biosensors
- Gas Sensing Nanomaterials and Sensors
- Conducting polymers and applications
- Graphene research and applications
- SARS-CoV-2 detection and testing
- Thermography and Photoacoustic Techniques
- Alzheimer's disease research and treatments
- Advanced biosensing and bioanalysis techniques
- Bone Tissue Engineering Materials
- Parkinson's Disease Mechanisms and Treatments
- Attention Deficit Hyperactivity Disorder
- Computational Drug Discovery Methods
- Ion channel regulation and function
- Escherichia coli research studies
- Hydrogels: synthesis, properties, applications
- Cellular Mechanics and Interactions
- Cardiac Arrhythmias and Treatments
- SARS-CoV-2 and COVID-19 Research
- Periodontal Regeneration and Treatments
- Collagen: Extraction and Characterization
- Tissue Engineering and Regenerative Medicine
Korea University
2020-2024
Sejong University
2021
Korea National University of Transportation
2021
Seoul National University Bundang Hospital
2021
Abstract The clinical use of bioactive molecules in bone regeneration has been known to have side effects, which result from uncontrolled and supraphysiological doses. In this study, we demonstrated the synergistic effect two molecules, morphogenic protein-2 (BMP-2) alendronate (ALN), by releasing them a sequential manner. Collagen-hydroxyapatite composite scaffolds functionalized using BMP-2 are loaded with biodegradable microspheres where ALN is encapsulated. results indicate an initial...
Graphene-based electronic textile (e-textile) gas sensors have been developed for detecting hazardous NO2 gas. For the e-textile sensor, electrical conductivity is a critical factor because it directly affects its sensitivity. To obtain highly conductive e-textile, biomolecules used gluing graphene to surface, though there remain areas improve, such as poor and flexibility. Herein, we dopamine-graphene hybrid yarn (DGY) where dopamine bio-inspired adhesive attach surface of yarns. The DGY...
The coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has evoked a worldwide pandemic. As the emergence of variants hampered neutralization capacity currently available vaccines, developing effective antiviral therapeutics against SARS-CoV-2 and its becomes significant challenge. main protease (Mpro) received increased attention as an attractive pharmaceutical target because pivotal role in viral replication proliferation. Here, we...
Hydroxyapatite nanoparticle-complexed collagen (HAP/Col) hydrogels have been widely used in biomedical applications as a scaffold for controlled drug release (DR). The time-variant mechanical properties (Young's modulus, E) of HAP/Col are highly relevant to the precise and efficient control DR. However, correlation between DR E remains unclear because lack nondestructive continuous measuring system. To reveal correlations, herein, we investigate behavior during 28 days using atomic force...
Colorimetric glucose sensors using enzyme-coronated gold nanoparticles have been developed for high-throughput assays to monitor the blood levels of diabetic patients. Although those shown sensitivity and wide linear detection ranges, they suffer from poor selectivity stability in detecting glucose, which has limited their practical use. To address this limitation, herein, we functionalized glucose-oxidase-coronated with an erythrocyte membrane (EM-GOx-GNPs). Because (EM) selectively...
Melanoma is visible unlike other types of cancer, but it still challenging to diagnose correctly because the difficulty in distinguishing between benign nevus and melanoma. We conducted a robust investigation melanoma, identifying considerable differences local elastic properties melanoma tissues by using atomic force microscopy (AFM) indentation histological specimens. Specifically, histograms modulus displayed multimodal Gaussian distributions, exhibiting heterogeneous mechanical...
The assembly of α-synuclein (αS) oligomers is recognized as the main pathological driver synucleinopathies. While elimination toxic αS shows promise for treatment Parkinson's disease (PD), discovery oligomer degradation drugs has been hindered by lack proper drug screening tools. Here, we report a platform monitoring efficacy αS-oligomer-degrading using amyloid-shelled gold nanocomplexes (ASGNs). We fabricate ASGNs in presence dopamine, mimicking vivo generation process oligomers. To test...
Abstract Melanoma is visible unlike other types of cancer, but it still challenging to diagnose correctly because the difficulty in distinguishing between benign nevus and melanoma. We conducted a robust investigation melanoma, identifying considerable differences local elastic properties melanoma tissues by using atomic force microscopy (AFM) indentation histological specimens. Specifically, histograms elasticity displayed multimodal Gaussian distributions, exhibiting heterogeneous...
Abstract Graphene electronic textiles (e-textiles) have attracted significant attention in various sensing applications owing to their strong advantages. During the fabrication of these textiles, there are factors consider, such as electrical conductivity, mechanical flexibility, weight, and applicability other practical applications. Bioinspired lotus fiber has appropriate advantages be used graphene e-textiles, including lightweight (<1 mg), eco-friendliness, crease-resistant, pilling...
Abstract Melanoma is visible unlike other types of cancer, but it still challenging to diagnose correctly because the difficulty in distinguishing between benign nevus and melanoma. We conducted a robust investigation melanoma, identifying considerable differences local elastic properties melanoma tissues by using atomic force microscopy (AFM) indentation histological specimens. Specifically, histograms elasticity displayed multimodal Gaussian distributions, exhibiting heterogeneous...