A5065440153- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Neuroscience and Neuropharmacology Research
- Public Health in Brazil
- Global Public Health Policies and Epidemiology
- Healthcare Systems and Reforms
- Maternal and Neonatal Healthcare
- Proteoglycans and glycosaminoglycans research
- Blood Pressure and Hypertension Studies
- Health and Lifestyle Studies
- Carbohydrate Chemistry and Synthesis
- Neuroscience and Neural Engineering
- Glycosylation and Glycoproteins Research
- Epilepsy research and treatment
- Pain Mechanisms and Treatments
- Healthcare Regulation
Universidade Federal do Rio de Janeiro
2019-2021
Pfizer (United States)
2013-2016
Significance Voltage-gated sodium (Na v ) channels contribute to physiological and pathophysiological electrical signaling in nerve muscle cells. Because Na channel isoforms exhibit tissue-specific expression, subtype selective modulation of this family provides important drug development opportunities. However, most available modulators are unable distinguish between subtypes, which limits their therapeutic utility because cardiac or nervous system toxicity. This study describes a new class...
The voltage dependent sodium channel Nav1.9, is expressed preferentially in peripheral sensory neurons and has been linked to human genetic pain disorders, which makes it target of interest for the development new therapeutics. However, characterization Nav1.9 pharmacology limited due part historical difficulty functionally expressing recombinant channels. Here we report successful generation human, mouse rat stably HEK-293 cells. These cells exhibit slowly activating inactivating inward...
Summary Objective Many previous studies of drug repurposing have relied on literature review followed by evaluation a limited number candidate compounds. Here, we demonstrate the feasibility more comprehensive approach using high‐throughput screening to identify inhibitors gain‐of‐function mutation in SCN 8A gene associated with severe pediatric epilepsy. Methods We developed cellular models expressing wild‐type or an R1872Q Na v 1.6 sodium channel encoded . Voltage clamp experiments HEK...
Resumo Fundamento Estudos sobre mortalidade por Insuficiência Cardíaca (IC) no Brasil e Regiões Geográficas (RG) são escassos. Objetivo Analisar a evolução temporal das taxas de IC sexo faixa etária Brasil, RG Unidades da Federação (UF), 1980 2018, associações com o Índice Desenvolvimento Humano Municipal (IDHM). Métodos Estudo séries temporais dos óbitos IC, faixas etárias, UF, 2018. Os [...]
Type II Congenital Disorders of Glycosylation (CDG-II) are a group diseases with challenging diagnostics characterized by defects in the processing glycans Golgi apparatus. Mass Spectrometry (MS) has been valuable tool definition CDG-II subtypes. While some subtypes associated specific N-glycan structures, others only produce changes relative levels, reinforcing demand for quantification methods.Plasma samples from control individuals were pooled, derivatized deuterated iodomethane (I-CD3),...
Abstract Background The Global Burden of Disease (GBD) does not produce estimates heart failure (HF) since this condition is considered the common end to several diseases (i.e., garbage code). This study aims analyze interactions between underlying and multiple causes death related HF in Brazil its geographic regions, by sex, from 2006 2016. Methods Descriptive a historical series certificates (DCs) deaths that occurred 2016, including both sexes all age groups. To identify as cause or...
Abstract Background Heart failure (HF) is a highly prevalent disease with high mortality rates worldwide, representing the final stage of large set cardiovascular diseases. Purpose To evaluate trend fromHF, by sex and Brazilian geoeconomic region, between 1980 2016. Methods Time series analysis underlying causes death from HF Population death-related data were obtained Information Technology Department Unified Health System (DATASUS/MS). Annual crude per 100,000 inhabitants calculated....