A5086757090- Family and Disability Support Research
- Genetics and Neurodevelopmental Disorders
- Respiratory viral infections research
- Autism Spectrum Disorder Research
- Pneumonia and Respiratory Infections
- Down syndrome and intellectual disability research
- Influenza Virus Research Studies
- Child Nutrition and Feeding Issues
- Cerebral Palsy and Movement Disorders
- Infant Development and Preterm Care
- Adolescent and Pediatric Healthcare
- Birth, Development, and Health
- Obesity, Physical Activity, Diet
- Bacterial Infections and Vaccines
- Vaccine Coverage and Hesitancy
- Childhood Cancer Survivors' Quality of Life
- Neonatal Respiratory Health Research
- Genomic variations and chromosomal abnormalities
- Maternal Mental Health During Pregnancy and Postpartum
- Prenatal Screening and Diagnostics
- Gestational Diabetes Research and Management
- Respiratory Support and Mechanisms
- Child and Adolescent Psychosocial and Emotional Development
- Neurogenetic and Muscular Disorders Research
- Eating Disorders and Behaviors
The Kids Research Institute Australia
2015-2024
The University of Western Australia
2015-2024
Jefferson Hospital
2024
Princess Margaret Hospital for Children
2015-2023
Perth Children's Hospital
2020-2023
Institute of Child Health
2018
Centre for Global Health Research
2008-2016
Government of Western Australia Department of Health
2015
Australian National University
2015
Murdoch Children's Research Institute
2015
Objective: To investigate the relationship between a child's weight and broad range of family maternal factors. Design, setting participants: Cross-sectional data from population-based prospective study, collected January 2004 December 2005, for 329 children aged 6–13 years (192 healthy weight, 97 overweight 40 obese) their mothers (n = 265) recruited paediatric hospital endocrinology department eight randomly selected primary schools in Perth, Western Australia. Main outcome measures:...
Using data on 2868 children born in the Western Australian Pregnancy Cohort (Raine) Study, we examined association between changes family socioeconomic status and childhood asthma.
<b>Objective</b> To re-evaluate the causal effect of interpregnancy interval on adverse birth outcomes, basis that previous studies relying between mother comparisons may have inadequately adjusted for confounding by maternal risk factors. <b>Design</b> Retrospective cohort study using conditional logistic regression (matching two intervals per so each acts as her own control) to model incidence outcomes a function interval; additional unconditional with adjustment confounders enabled...
Background As well as being highly comorbid conditions, autism spectrum disorders (ASD) and intellectual disability (ID) share a number of clinically-relevant phenomena. This raises questions about similarities overlap in diagnosis aetiological pathways that may exist for both conditions. Aims To examine maternal conditions perinatal factors children diagnosed with an ASD, or without ID, ID unknown cause, compared unaffected children. Methods The study population comprised all live singleton...
Background Research findings investigating the sociodemographics of autism spectrum disorder (ASD) have been inconsistent and rarely considered presence intellectual disability (ID). Methods We used population data on Western Australian singletons born from 1984 to 1999 (n = 398,353) examine sociodemographic characteristics children diagnosed with ASD or without ID, ID compared non-affected children. Results The profiles for four categories examined, mild-moderate severe varied considerably...
The clinical characteristics of children diagnosed with Rett syndrome are well described. Survival and how these persist or change in adulthood less documented. This study aimed to describe overall survival adult health those syndrome.Using the Kaplan-Meier method, we estimated individuals registered Australian Database (ARSD) who had been followed for up 20 years (n = 396). We then conducted logistic linear regression analyses investigating epilepsy, musculoskeletal, gastrointestinal,...
Objective: The aims of the present study were to (i) examine relationship between children's degree adiposity and psychosocial functioning; (ii) compare patterns clustering measures healthy weight overweight/obese children. Method: Cross-sectional data from a population-based cohort 158 weight, 77 overweight, 27 obese children aged 8–13 years analysed. Height, depression, quality life, self-esteem, body dissatisfaction, eating disorder symptoms, peer relationships behavioural emotional...
Abstract Recent animal studies suggest links between MeCP2 function and sensitivity to pain. This study investigated the nature prevalence of atypical pain responses in Rett syndrome their relationships with specific MECP2 mutations. Families enrolled Australian Syndrome Database (ARSD) InterRett database participated this study. Cases a known pathogenic mutation, whose families had completed questionnaire on registration answered questions were included (n = 646). Logistic regression was...
Background: Preliminary evidence suggests that prenatal testosterone exposure may be associated with language delay. However, no study has examined a large sample of children at multiple time‐points. Methods: Umbilical cord blood samples were obtained 861 births and analysed for bioavailable (BioT) concentrations. When participating offspring 1, 2 3 years age, parents 767 (males = 395; females 372) completed the Infant Monitoring Questionnaire (IMQ), which measures Communication, Gross...
Summary Rett syndrome is a rare neurodevelopmental disorder usually affecting females, and associated with mutation in the MECP 2 gene. Sleep problems occur commonly we investigated trajectories influences of age, treatments. Data were collected at six time points over 12 years from 320 families registered Australian Syndrome Database. Regression analysis was used to investigate relationships between sleep disturbances, type use treatment, latent class growth performed identify problem...
The aim of this study was to measure umbilical blood androgen concentrations in a birth cohort using highly specific liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay and assesses the effects sex, labor, gestational age on fetal levels at birth. We performed prospective mixed arterial venous cord serum from 803 unselected singleton pregnancies general obstetric population Western Australia. Total testosterone (TT), Δ4-androstenedione, dehydroepiandrosterone were extracted...
Objective: Results from studies examining associations between serum 25-hydroxyvitamin D (25(OH)D) concentrations and depressive symptoms are equivocal. We investigated the relationship 25(OH)D of depression, anxiety stress in a cross-sectional analysis population-based sample young adults participating Western Australian Pregnancy Cohort (Raine) Study. Methods: Participants provided blood at 20-year follow-up (March 2010-April 2012) for measurement concentrations. Mental health were...
There are few studies evaluating the effectiveness of trivalent influenza vaccination (TIV) in young children, particularly children <2 years. The Western Australian Influenza Vaccine Effectiveness Study commenced 2008 to evaluate a program providing TIV aged 6 59 months.An observational study enrolling with influenza-like illness presenting tertiary pediatric hospital was conducted (2008-2012). Vaccination status determined by parental questionnaire and confirmed via national immunization...
To investigate associations between functioning, community participation, and quality of life (QoL) identify whether participation mediates the effects functioning on QoL.The caregivers 435 children (211 females, 224 males; mean age 12y; SD 3y 11mo; range 5-18y) with intellectual disability autism spectrum disorder, cerebral palsy, Down syndrome, or Rett syndrome reported their child's (dependence for managing personal needs, mobility, communication, eye contact when speaking), frequency...
Study Design. Population-based longitudinal observational study. Objective. To describe the prevalence of scoliosis in Rett syndrome, structural characteristics and progression, taking into account influences age, genotype, ambulatory status. Summary Background Data. Scoliosis is most common orthopedic comorbidity syndrome yet very little known about its natural history influencing factors such as Methods. The infrastructure Australian Syndrome Database was used to identify all cases with...
Rett syndrome is a pervasive neurodevelopmental disorder associated with pathogenic mutation on the MECP2 gene. Impaired movement fundamental component and Syndrome Gross Motor Scale was developed to measure gross motor abilities in this population. The current study investigated validity reliability of Scale. Video data showing supplemented parent report collected for 255 girls women registered Australian Database, factor structure relationships between scores, age genotype were...
Influenza vaccines are reviewed each year, and often changed, in an effort to maintain their effectiveness against drifted influenza viruses. There is however no regular review of vaccine during, or at the end of, Australian seasons. It possible use a case control method estimate from surveillance data when all patients system tested for vaccination status known.Influenza-like illness (ILI) conducted during season sentinel general practices scattered throughout Victoria, Australia. Over five...
the Western Australian Influenza Vaccine Effectiveness study commenced in 2008 to evaluate a new program provide free influenza vaccine all children aged 6 59 months. We aimed assess protective effect of inactivated vaccination these children.We conducted prospective case-control general practices and hospital emergency department, testing eligible patients for range other common respiratory viruses. effectiveness (VE) against laboratory-confirmed was estimated with cases defined as an...