A5038032437- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Air Quality and Health Impacts
- Tracheal and airway disorders
- Viral gastroenteritis research and epidemiology
- Climate Change and Health Impacts
- Asthma and respiratory diseases
- Congenital Diaphragmatic Hernia Studies
- COVID-19 Clinical Research Studies
- Inhalation and Respiratory Drug Delivery
- Respiratory Support and Mechanisms
- Respiratory and Cough-Related Research
- Bacterial Infections and Vaccines
- Neonatal Respiratory Health Research
- Birth, Development, and Health
- Pharmaceutical studies and practices
- Noise Effects and Management
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Maternal and Neonatal Healthcare
- Obesity, Physical Activity, Diet
- Child Nutrition and Water Access
- Parvovirus B19 Infection Studies
- Gestational Diabetes Research and Management
- Environmental and biological studies
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2008-2024
Universidade de São Paulo
2007-2022
Hospital Universitário da Universidade de São Paulo
2000-2017
Universidade Cidade de São Paulo
2017
Universidade Brasil
2002-2015
Sociedade Brasileira de Pediatria
2011
Human respiratory syncytial virus (HRSV) is the major cause of lower tract infections in children under 5 years age and elderly, causing annual disease outbreaks during fall winter. Multiple lineages HRSVA HRSVB serotypes co-circulate within a single outbreak display strongly temporal pattern genetic variation, with replacement dominant genotypes occurring consecutive years. In present study we utilized phylogenetic methods to detect map sites subject adaptive evolution G protein HRSVB. A...
It has been widely demonstrated that air pollution can affect human health and certain pollutant gases lead to adverse obstetric outcomes, such as preeclampsia fetal growth restriction.We evaluated the influence of individual maternal exposure on placental volume vascularization in first trimester pregnancy.This was a cross-sectional study low-risk pregnant women living São Paulo, Brazil. The carried passive personal NO2 O3 monitors week preceding evaluation. We employed virtual organ...
The respiratory viruses are recognized as the most frequent lower tract pathogens for infants and young children in developed countries but less is known developing populations. authors conducted a prospective study to evaluate occurrence, clinical patterns, seasonal trends of viral infections among hospitalized with disease (Group A). presence children's nasopharyngeal was assessed at admission pediatric ward. Cell cultures immunofluorescence assays were used identification. Complementary...
OBJETIVO: Detecção de oito vírus respiratórios mais comuns: respiratório sincicial humano (VRSH), influenza tipo A e B (IA IB), da parainfluenza 1, 2 3 (VPIH1, 3), adenovírus (Ad) metapneumovírus (MPVH), a fim estabelecer etiologia das infecções respiratórias agudas (IRA) epidemiologia desses em crianças pequenas atendidas no Hospital Universitário Universidade São Paulo, Brasil, durante o ano 2003. MÉTODOS: vigilância epidemiológica foi realizada todas as menores 5 anos hospitalizadas por...
Abstract Epidemiological and molecular characteristics of human metapneumovirus (hMPV) were compared with respiratory syncytial virus (hRSV) in infants young children admitted for acute lower tract infections a prospective study during four consecutive years subtropical Brazil. GeneScan polymerase chain assays (GeneScan RT‐PCR) used to detect hMPV hRSV nasopharyngeal aspirates 1,670 January 2003 December 2006. detected, respectively, 191 (11.4%) 702 (42%) the at Sao Paulo University...
Congenital hypothyroidism (CH) is the most common congenital endocrine disorder, with an incidence of 1:2,000 to 1:4,000 live births and it a leading preventable mental retardation. Neonatal Screening Programs allow early identification disease adequate treatment affected children can avoid complications related deprivation hormone. Most cases primary (85%) are due thyroid dysgenesis (ectopia, hypoplasia or agenesis) while remaining result from defects in hormone synthesis. Affected (> 95%)...
Acute bronchiolitis is a leading cause of infant hospitalization and most commonly caused by respiratory syncytial virus. Etiological tests are not required for its diagnosis, but the influence viral screening on therapeutic approach acute remains unclear.A historical cohort was performed to assess impact drug prescriptions. The study included infants up one year age who were hospitalized bronchiolitis. Virus using immunofluorescence assays in nasopharyngeal aspirates. clinical data obtained...
Women's health during their reproductive years and whilst pregnant has implications for children's health, both in utero childhood. Associations of women's pre-pregnancy dietary patterns (DP) with maternal socio-demographic characteristics nutrient intake were investigated ProcriAr cohort study São Paulo/Brazil, 2012.The DPs 454 women by principal component factor analysis, using information from a validated 110-item food frequency questionnaire. Multiple linear regression models identified...
INTRODUCTION: Diabetes mellitus is a highly prevalent chronic disease.Type 1 diabetes usually develops during infancy and adolescence may affect the quality of life adolescents.OBJECTIVE: To evaluate adolescents with type in metropolitan region western central Brazil.METHODS: Adolescents aged 10-19 years who had been diagnosed at least year previously were included.Patients verbal communication difficulties, severe disease, symptomatic hypo-or hyperglycemic crisis as well those without an...
Abstract In a study of acute respiratory disease, two collections nasopharyngeal aspirates (NPA) were obtained from children hospitalized at the Pediatric Clinic University Hospital, São Paulo, in 1995 and 2000. Adenovirus was detected 33 (8.2%) 401 followed. These viruses isolated HEp‐2, HEK‐293, or NCI‐H292 cells serotyped by neutralization. The genome types determined after restriction analyses genomic DNA extracted infected cells. Nineteen isolates characterized as Human adenovirus B ,...
OBJETIVO: Comparar a gravidade de infeccoes causadas por um unico virus (VSR) com coinfeccoes. METODOS: Este estudo avaliou uma coorte historica lactentes infeccao aguda VSR. Secrecao nasofaringe foi coletada todos os pacientes rotineiramente para pesquisa viral usando tecnicas biologia molecular. Os seguintes desfechos foram analisados: tempo total internacao, duracao da oxigenioterapia, admissao em unidade terapia intensiva e uso ventilacao mecânica. resultados ajustados fatores...
We have evaluated the cellular and humoral immune response to primary respiratory syncytial virus (RSV) infection in young infants. Serum specimens from 65 patients <=12 months of age (39 males 26 females, 28 cases <3 37 > or = 3 months; median ± 3.9 months) were tested for anti-RSV IgG subclass antibodies by EIA. Flow cytometry was used characterize cell surface markers expressed on peripheral blood mononuclear cells (PBMC) 29 RSV-infected children. There a low rate seroconversion children...
Objective: The aim of this study was to evaluate the QuickVue ® RSV Test Kit (QUIDEL Corp, CA, USA) as a screening tool for respiratory syncytial virus in children with acute disease comparison indirect immunofluorescence assay gold standard.In Brazil, rapid antigen detection tests are not routinely utilized diagnostic tool, except diagnosis dengue and influenza.Methods: authors retrospectively analyzed 486 nasopharyngeal aspirate samples from under age 5 infection, between December 2013...
to evaluate the frequency of respiratory viral infections in hospitalized infants with clinical suspicion pertussis, and analyze their characteristics at hospital admission outcomes.a historical cohort study was performed a reference service for which research viruses also routine problems. All reported as suspected cases pertussis were included. Tests Bordetella (BP) (polymerase chain reaction/culture) (RVs) (immunofluorescence) performed. Patients who received macrolides before...
Respiratory syncytial virus (RSV) is a major etiological agent of lower respiratory tract infection in infants. Genotypes this and the role infants' serum antibodies have yet to be fully clarified. This knowledge important for development effective therapeutic prophylactic measures.To evaluate types genotypes RSV causing infants, analyze association subtype-specific with occurrence presence mothers their profile childrens' antibodies.This was prospective study on infants hospitalized...
The maternal pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) influence infant outcomes. This study identified patterns of habitual dietary intake in 385 pregnant women São Paulo explored their associations with excessive (EGWG). Weight at the first visit (<14 weeks) was used as a proxy for weight. Food consumption assessed using 24HR method, administered twice each trimester, were by principal component analysis. Three identified: “Vegetables Fruits,” “Western,”...
Human respiratory syncytial virus is the main cause of infections in infants. Several HRSV genotypes have been described. Goals . To describe that caused São Paulo (2013–2015) and to analyze their clinical/epidemiological features. Methods 94 infants (0–6 months) with bronchiolitis were studied. Clinical/epidemiological information was collected; a search for 16 viruses nasopharyngeal secretion (PCR-real-time conventional, sequencing, phylogenetic analyses) performed. Results The mean age...
To evaluate pulmonary function in the first and third trimesters of pregnancy analyze influence parity smoking on spirometry parameters.This longitudinal prospective study included a cohort 120 pregnant women. The inclusion criteria were as follows: singleton pregnancy, gestational age less than 13.86 weeks, no preexisting maternal diseases. exclusion change address, abortion, inadequate testing. ClinicalTrials.gov: NCT02807038.A decrease values forced vital capacity expiratory volume noted...