A5035095164- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Systemic Sclerosis and Related Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Cytokine Signaling Pathways and Interactions
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Prion Diseases and Protein Misfolding
- Vestibular and auditory disorders
- Cell Adhesion Molecules Research
- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Effects of Vibration on Health
- Systemic Lupus Erythematosus Research
- Amyotrophic Lateral Sclerosis Research
- Radiation Dose and Imaging
- Pregnancy and preeclampsia studies
- Cerebral Palsy and Movement Disorders
- T-cell and B-cell Immunology
- Autoimmune and Inflammatory Disorders Research
- Blood Coagulation and Thrombosis Mechanisms
Cleveland Clinic
2021-2023
University of Washington
2012-2023
Cleveland Clinic Lerner College of Medicine
2021
Abstract Multiple sclerosis (MS) is an autoimmune disease in which inflammatory lesions lead to tissue injury the brain and/or spinal cord. The specific sites of are strong determinants clinical outcome MS, but pathways that determine whether damage occurs or cord not understood. Previous studies mouse models MS demonstrated IFN-γ and IL-17 regulate lesion localization within brain; however, mechanisms by these cytokines mediate their effects have been identified. In present study, we show...
Abstract Objective Evaluation of serum neurofilament light chain (sNfL), measured using high‐throughput assays on widely accessible platforms in large, real‐world MS populations, is a critical step for sNfL to be utilized clinical practice. Methods Multiple Sclerosis Partners Advancing Technology and Health Solutions (MS PATHS) network healthcare institutions the United States Europe collecting standardized clinical/imaging data biospecimens during routine clinic visits. was 6974 201 healthy...
<sec> <title>BACKGROUND</title> The benefits of physical activity are well-established in people with multiple sclerosis (MS), yet most MS insufficiently active. </sec> <title>OBJECTIVE</title> This article describes the study protocol for a randomized controlled trial designed to understand whether ExerciseRx digital health platform improves activity, symptoms, and functioning adults MS. <title>METHODS</title> Participants ambulatory (N = 106) who engage <150 minutes per week moderate...
Thrombin is a multifunctional serine proteinase that induces variety of responses from neural cells by cleavage proteinase-activated receptors (PARs) including PAR1 and PAR4. Thrombin/PAR signaling has been implicated in the neuroinflammatory response occurs brain following stroke other central nervous system pathologies. The involves astrocytes results induction proinflammatory chemokines interleukin-8 (IL-8 or CXCL8) interferon-γ-induced protein-10 (IP-10 CXCL10) these cells. Astroctyes...
Aerobic exercise (AEx) has many potential benefits; however, it is unknown whether individuals with multiple sclerosis (MS) can attain the optimal intensity and duration to harness its effects. Forced-rate (FE) a novel paradigm in which voluntary pedaling rate during cycling supplemented achieve higher intensity. The aim of this pilot trial was investigate feasibility initial efficacy 12-week FE or (VE) intervention for MS.
Background: This Multiple Sclerosis (MS) is a Central Nervous System (CNS) disease characterized by demyelination or axonal loss encompassing several clinical subtypes—Relapsing-Remitting MS (RRMS), Secondary-Progressive (SPMS), and Primary-Progressive (PPMS). Strategies for treating progressive forms are limited, better understanding of underlying pathophysiology essential. Method: Somatosensory Evoked Potentials (SEP) were analyzed CNS conduction slowing caused myelin impairment defined...