A5012214833- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Neurogenetic and Muscular Disorders Research
- Viral Infections and Immunology Research
- RNA Interference and Gene Delivery
- Axon Guidance and Neuronal Signaling
- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Cancer-related molecular mechanisms research
- RNA regulation and disease
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetics and Neurodevelopmental Disorders
Charité - Universitätsmedizin Berlin
2020-2023
Freie Universität Berlin
2020-2023
Humboldt-Universität zu Berlin
2020-2021
Institute of Cell Biology and Neurobiology
2020
Laboratoire de Biochimie
2020
Minor and major spliceosomes control splicing of distinct intron types are thought to act largely independent one another. SR proteins essential regulators mostly connected the spliceosome. Here, we show that Srsf10 expression is controlled through an autoregulated minor intron, tightly correlating with spliceosome abundance across different tissues differentiation stages in mammals. Surprisingly, all other also correlate Srsf10, abolishing autoregulation by Crispr/Cas9-mediated deletion...
The seat of higher-order cognitive abilities in mammals, the neocortex, is a complex structure, organized several layers. different subtypes principal neurons are distributed precise ratios and at specific positions these layers generated by same neural progenitor cells (NPCs), steered spatially temporally specified combination molecular cues that incompletely understood. Recently, we discovered an alternatively spliced isoform TrkC receptor lacking kinase domain, TrkC-T1, determinant...
Regulation and functionality of species-specific alternative splicing has remained enigmatic to the present date. Calcium/calmodulin-dependent protein kinase IIβ (CaMKIIβ) is expressed in several splice variants plays a key role learning memory. Here, we identify characterize primate-specific CAMK2B isoforms, which show altered kinetic properties changes substrate specificity. Furthermore, demonstrate that achieved through branch point weakening during evolution. We reducing site strengths...
Neocortical projection neurons are generated by neural progenitor cells (NPCs) within the ventricular and subventricular zone. While early NPCs can give rise to both deep upper layer neurons, late progenitors restricted neurogenesis. The molecular mechanisms controlling differentiation potential of versus unknown. Here, we report a novel function for TrkC-T1, non-catalytic isoform neurotrophin receptor TrkC, that is distinct from TrkC-TK+, full-length isoform. We provide direct evidence...
Abstract Regulation and functionality of species-specific alternative splicing has remained enigmatic to the present date. Calcium/calmodulin-dependent protein kinase IIβ (CaMKIIβ) is expressed in several splice variants plays a key role learning memory. Here, we identify characterize primate-specific CAMK2B isoforms, which show altered kinetic properties changes substrate specificity. Furthermore, demonstrate that Camk2β achieved through branch point weakening during evolution. We reducing...