A5101978477- Cutaneous Melanoma Detection and Management
- Pregnancy-related medical research
- Melanoma and MAPK Pathways
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Shakespeare, Adaptation, and Literary Criticism
- Nonmelanoma Skin Cancer Studies
- Skin Protection and Aging
- Travel Writing and Literature
- Injury Epidemiology and Prevention
- Dialysis and Renal Disease Management
- Radiology practices and education
- Atrial Fibrillation Management and Outcomes
- Healthcare Quality and Management
- Historical Studies and Socio-cultural Analysis
- Thomas Hardy Literature Studies
- Lung Cancer Treatments and Mutations
- AI in cancer detection
- Urban Green Space and Health
- Poetry Analysis and Criticism
- Molecular Biology Techniques and Applications
- Joseph Conrad and Literature
- Tuberculosis Research and Epidemiology
- German Colonialism and Identity Studies
- Health and Medical Studies
University of Pittsburgh
2011-2024
Bioscience (China)
2023-2024
Friends United
2023
AbbVie (United States)
2022
Alameda County Public Health Department
2022
American Academy of Ophthalmology
2022
Mayo Clinic
2022
Baylor College of Medicine
2020
Children's Hospital of Pittsburgh
2011-2019
McGowan Institute for Regenerative Medicine
2015-2019
Enhanced diastolic calcium (Ca2+) release through ryanodine receptor type-2 (RyR2) has been implicated in atrial fibrillation (AF) promotion. Diastolic sarcoplasmic reticulum Ca2+ leak is caused by increased RyR2 phosphorylation PKA (protein kinase A) or CaMKII (Ca2+/calmodulin-dependent kinase-II) phosphorylation, less dephosphorylation protein phosphatases. However, considerable controversy remains regarding the molecular mechanisms underlying altered function AF. We thus aimed to...
PURPOSE The DecisionDx-Melanoma 31-gene expression profile (31-GEP) test is validated to classify cutaneous malignant melanoma (CM) patient risk of recurrence, metastasis, or death as low (class 1A), intermediate 1B/2A), high 2B). This study aimed examine the effect 31-GEP testing on survival outcomes and confirm prognostic ability at population level. METHODS Patients with stage I-III CM a clinical result between 2016 2018 were linked data from 17 SEER registries (n = 4,687) following...
National Comprehensive Cancer Network guidelines recommend sentinel lymph node biopsy (SLNB) for patients with > 10% risk of positivity, consider SLNB 5–10% risk, and foregoing < 5% risk. The integrated 31-gene expression profile (i31-GEP) algorithm combines the 31-GEP clinicopathologic variables, estimating SLN positivity i31-GEP prediction accuracy was assessed in T1-T2 tumors enrolled prospective, multicenter DECIDE study (n = 322). To determine if incorporating into decision-making...
Background: 31-GEP prognostic testing is an important tool for patients diagnosed with invasive melanoma and stratifies into groups at low, intermediate, or high risk of recurrence, metastasis, death. The pathway to a diagnosis not always straightforward often dermatopathologists utilize molecular assist in the accurate classification ambiguous lesions, which varied tissue amounts. Separately, 23-GEP test objective ancillary diagnostic uses RNA extracted from 9 unstained slides. Both...
"CGE25-104: The 31-GEP Identifies Patients With Early-Stage I-IIA Cutaneous Melanoma at High Risk of Melanoma-Specific and Overall Mortality" published on 28 Mar 2025 by National Comprehensive Cancer Network.
Abstract Objectives/Hypothesis: Determine the role of mastoid volume in middle ear pressure (MEP) regulation. The hypothesis was that inert gas exchange between blood and (ME) is slower for larger volumes. Study Design: Prospective. Methods: For 21 enrolled subjects, bilateral surface areas volumes tympanum were measured from computed tomography scans 20 subjects with a wide range Then, 19 reclined chair, fitted non‐rebreathing mask breathed room air minutes (acclimation), composition 25% N...
Background 'Healthy' aging drives structural and functional changes in the heart including maladaptive electrical remodeling, fibrosis inflammation, which lower threshold for cardiovascular diseases such as failure (HF) atrial fibrillation (AF). Despite mixed results recent clinical trials, Relaxin-therapy 2-days could reduce mortality by 37% at 180-days post-treatment, patients with acute decompensated HF. Relaxin's short life-span (hours) but long-lasting protective actions led us to test...
Background: Patients with stage I cutaneous melanoma (CM) are considered at low risk for metastasis or specific death; however, because the majority of patients diagnosed disease, they represent largest number deaths annually. The 31-gene expression profile (31-GEP) test has been prospectively validated to provide prognostic information independent staging, classifying as (Class 1A), intermediate 1B/2A), high 2B) poor outcomes. Methods: enrolled in previous studies 31-GEP were combined and...
Abstract Healthy aging results in cardiac structural and electrical remodeling that increases susceptibility to cardiovascular diseases. Relaxin, an insulin-like hormone, suppresses atrial fibrillation, inflammation fibrosis aged rats but the mechanisms-of-action are unknown. Here we show relaxin treatment of reverses pathological (increasing Nav1.5 expression localization Connexin43 intercalated disks) by activating canonical Wnt signaling. In isolated adult ventricular myocytes,...
Abstract Background Chronic kidney disease (CKD) is characterized by dysbiosis, elevated levels of uremic toxins, systemic inflammation, and increased markers oxidative stress. These factors lead to an risk cardiovascular (CVD) which common among CKD patients. Supplementation with high amylose maize resistant starch type 2 (RS-2) can change the composition gut microbiota, reduce inflammation stress in patients end-stage renal disease. However, impact RS-2 supplementation has not been...
Pulmonary arterial hypertension (PAH) leads to right ventricular cardiomyopathy and cardiac dysfunctions where in the clinical setting, arrest is likely cause of death, ~70% PAH patients. We investigated phenotype hearts tested hypothesis that insulin-like hormone, Relaxin could prevent maladaptive remodeling protect against a animal model. was induced rats with sugen (20 mg/kg), hypoxia then normoxia (3-weeks/each); relaxin (RLX = 0, 30 or 400 μg/kg/day, n ≥ 6/group) delivered...
Abstract Drug development is a resource and time-intensive process resulting in attrition rates of up to 90%. As result, repurposing existing drugs with established safety pharmacokinetic profiles gaining traction as way accelerating therapeutics development. Here we have developed unique machine learning-driven Natural Language Processing biomedical semantic technologies that mine over 53 million documents automate the generation 911M edge knowledge graph. We then applied subgraph queries...
Referees’ reports are often demoralizing to authors. It is possible write a report that supportive and helpful by following two rules: Say what good about piece of work, say how it can be improved.
Due to the nature of their work, state park workers receive substantial exposure sunlight, putting them at an increased risk developing skin cancer. Increased use sun protection behaviors can reduce this risk. Using health belief model (HBM) as a theoretical framework, purpose study was assess factors associated with among state-park workers. In cross-sectional study, convenience sample participants were recruited from 23 parks in Southeastern USA complete self-administered questionnaire...
Objective: Legitimate opioid prescriptions have been identified as a risk factor for misuse in pediatric patients. In 2014, Pennsylvania legislation expanded prescription drug monitoring program (PDMP) to curb inappropriate controlled substance prescriptions. The authors’ objective was describe recent prescribing trends at large, health system situated region with one of the highest opioid-related death rates United States and examine impact PDMP on trends.Design: Quasi-experimental...
Background: Associations of physical activity with all-cause mortality seem to be quite strong, but little is known about potential effect modifiers as sex, race/ethnicity, age, and obesity. Methods: Data the Third National Health Nutrition Examination Survey (NHANES III), conducted 1988−1994 follow-up until 2006, were used compare risk between different levels leisure-time (LTPA) occupational (OPA). Cox proportional hazards models estimate hazard ratios (HRs) 95% confidence intervals (CIs)....
Communication is central to the effectiveness of nonviolent action: methods protest and persuasion are essentially means communication, while noncooperation intervention have crucial communicative dimensions.As a mode political nonviolence can be contrasted with rational dialogue, electoral politics violence, stands out from them in combining high transformative potential dialogue participation.The more well studied dimensions as communication opponents, power equalization prepare for...