A5045461759- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Adipose Tissue and Metabolism
- Heart Failure Treatment and Management
- Nitric Oxide and Endothelin Effects
- Mitochondrial Function and Pathology
- Liver Disease Diagnosis and Treatment
- Sirtuins and Resveratrol in Medicine
- Eicosanoids and Hypertension Pharmacology
- Cardiac Fibrosis and Remodeling
- Cardiovascular Issues in Pregnancy
- Renin-Angiotensin System Studies
- Cardiac Valve Diseases and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Respiratory and Cough-Related Research
- Diet and metabolism studies
- Music and Audio Processing
- Phonocardiography and Auscultation Techniques
- Metabolism, Diabetes, and Cancer
- Congenital Heart Disease Studies
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
- Head and Neck Cancer Studies
- Coenzyme Q10 studies and effects
- ATP Synthase and ATPases Research
Indiana University – Purdue University Indianapolis
2005-2024
The Japanese Society of Gastroenterological Surgery
2024
Indiana University School of Medicine
2018-2024
Onomichi General Hospital
2024
Hiroshima University
2024
National Yang Ming Chiao Tung University
2024
University of Pittsburgh
2012-2024
Mackay Memorial Hospital
2007-2024
Iwate Medical University
2024
University of Pittsburgh Medical Center
2016-2023
Although aging is a known risk factor for idiopathic pulmonary fibrosis (IPF), the pathogenic mechanisms that underlie effects of advancing age remain largely unexplained. Some age-related neurodegenerative diseases have an etiology related to mitochondrial dysfunction. Here, we found alveolar type II cells (AECIIs) in lungs IPF patients exhibit marked accumulation dysmorphic and dysfunctional mitochondria. These abnormalities AECIIs were associated with upregulation ER stress markers...
Background— Pulmonary hypertension associated with heart failure preserved ejection fraction (PH-HFpEF) is an increasingly recognized clinical complication of metabolic syndrome. No adequate animal model PH-HFpEF available, and no effective therapies have been identified to date. A recent study suggested that dietary nitrate improves insulin resistance in endothelial nitric oxide synthase null mice, multiple studies reported both its active metabolite, nitrite, therapeutic activity...
Background: Many patients with heart failure preserved ejection fraction have metabolic syndrome and develop exercise-induced pulmonary hypertension (EIPH). Increases in vascular resistance portend a poor prognosis; this phenotype is referred to as combined precapillary postcapillary (CpcPH). Therapeutic trials for EIPH CpcPH been disappointing, suggesting the need strategies that target upstream mechanisms of disease. This work reports novel rat models dysfunction centered around...
Pulmonary hypertension (PH) associated with heart failure preserved ejection fraction (PH-HFpEF; World Health Organization Group II) secondary to left ventricular (LV) diastolic dysfunction is the most frequent cause of PH. It an increasingly recognized clinical complication metabolic syndrome. To date, no effective treatment has been identified, and genetically modifiable mouse model available for advancing our understanding PH-HFpEF. develop a PH-HFpEF, we exposed 36 strains 20 weeks...
The dynamic regulation of endothelial pathophenotypes in pulmonary hypertension (PH) remains undefined. Cellular senescence is linked to PH with intracardiac shunts; however, its across subtypes unknown. Since deficiency iron-sulfur (Fe-S) clusters pathogenic PH, we hypothesized that a Fe-S biogenesis protein, frataxin (FXN), controls senescence. An subpopulation rodent and patient lungs exhibited reduced FXN elevated In vitro, hypoxic inflammatory abrogated activity Fe-S-containing...
A reliable, remote, and continuous real-time respiratory sound monitor with automated analysis ability is urgently required in many clinical scenarios-such as monitoring disease progression of coronavirus 2019-to replace conventional auscultation a handheld stethoscope. However, robust computerized algorithm for breath phase detection adventitious at the recording level has not yet been validated practical applications. In this study, we developed lung database (HF_Lung_V1) comprising 9,765...
BACKGROUND: The ubiquitin-proteasome system regulates protein degradation and the development of pulmonary arterial hypertension (PAH), but knowledge about role deubiquitinating enzymes in this process is limited. UCHL1 (ubiquitin carboxyl-terminal hydrolase 1), a deubiquitinase, has been shown to reduce AKT1 (AKT serine/threonine kinase 1) degradation, resulting higher levels. Given that pathological hypertension, we hypothesized deficiency attenuates PAH by means reductions AKT1. METHODS:...
Pulmonary hypertension (PH) is a major complication linked to adverse outcomes in heart failure with preserved ejection fraction (HFpEF), yet no specific therapies exist for PH associated HFpEF (PH-HFpEF). We have recently reported on the role of skeletal muscle SIRT3 (sirtuin-3) modulation PH-HFpEF, suggesting novel endocrine signaling pathway pulmonary vascular remodeling.
Objectives Being overweight, with a body mass index >25, is associated multiple comorbidities, including chronic kidney disease (CKD). A plant-based diet, such as vegetarian or lacto-ovo serves preventive strategy for CKD in patients. We hypothesized that diet lowers the occurrence of overweight subjects. Methods The retrospective study was performed Taipei Tzu Chi Hospital by self-paid health-exam. Age younger than 40 years old and subjects without sufficient biochemical hematologic...
Protocadherin 10 ( PCDH10 ), a novel tumor suppressor gene in human cancers, is located common deleted region at chromosome 4q28 colorectal cancer (CRC). This study aimed to ascertain the genetic loss of and its clinical relevance CRC explore function PCDH10. The deletion was determined 171 pairs primary tumors corresponding normal mucosae by heterozygosity study. In total, 53 carcinomas were positive for allelic . aberration significantly associated with progression distant metastasis p =...
Serum albumin facilitates the transport of free fatty acids (FFAs) from adipose tissue to other organs. It was not known if impeding this process could protect hepatic steatosis and metabolic dysfunction in obesity. We tested whether knockout (Alb−/−) mice would exhibit a reduction plasma FFA concentration, reduced lipid accumulation, improved glucoregulation as compared wild-type (WT) mice. Male homozygous WT controls were fed low-fat diet (LFD) or high-fat (HFD). Alb−/− exhibited similar...
Objective: Pulmonary hypertension (PH) due to left heart disease (group 2), especially in the setting of failure with preserved ejection fraction (HFpEF), is most common cause PH worldwide; however, at present, there no proven effective therapy available for its treatment. PH-HFpEF associated insulin resistance and features metabolic syndrome. The stable prostacyclin analog, treprostinil, an widely used Food Drug Administration-approved drug treatment pulmonary arterial hypertension. While...