A5070622646- Photoreceptor and optogenetics research
- Neuroscience and Neural Engineering
- Optical Imaging and Spectroscopy Techniques
- Advanced Optical Sensing Technologies
- CCD and CMOS Imaging Sensors
- Advanced Fluorescence Microscopy Techniques
- Photoacoustic and Ultrasonic Imaging
- Neural dynamics and brain function
- Molecular Communication and Nanonetworks
- Advanced Memory and Neural Computing
- Non-Invasive Vital Sign Monitoring
Columbia University
2019-2024
New York Proton Center
2023
Optical neurotechnologies use light to interface with neurons and can monitor manipulate neural activity high spatial-temporal precision over large cortical extents. While there has been significant progress in miniaturizing microscope for head-mounted configurations, these existing devices are still very bulky could never be fully implanted. Any viable translation of technologies human will require a much more noninvasive, implantable form factor. Here, we leverage advances microelectronics...
We present an implantable single photon shank-based imager, monolithically integrated onto a CMOS IC. The imager comprises of 512 avalanche diodes distributed along two shanks, with 6-bit depth in-pixel memory and on-chip digital-to-time converter. To scale down the system to minimally invasive form factor, we substitute optical filtering focusing elements time-gated, angle-sensitive detection system. computationally reconstructs position fluorescent sources within three-dimensional volume...
This paper presents a device for time-gated fluorescence imaging in the deep brain, consisting of two on-chip laser diodes and 512 single-photon avalanche (SPADs). The edge-emitting deliver excitation above SPAD array, parallel to imager. In time domain, diode illumination is pulsed time-gated, allowing rejection up O.D. 3 at 1 ns time-gate delay. Each pixel masked with Talbot gratings enable mapping 2D array photon counts into 3D image. image achieves resolution 40, 35, 73 μm x, y, z...
Emerging optical functional imaging and optogenetics are among the most promising approaches in neuroscience to study neuronal circuits. Combining both methods into a single implantable device enables all-optical neural interrogation with immediate applications freely-behaving animal studies. In this paper, we demonstrate such capable of recording stimulation over large cortical areas. This surface exploits lens-less computational novel packaging scheme achieve an ultra-thin...
The advent of genetically encoded voltage and calcium indicators optogenetic probes has unlocked unprecedented capabilities, including near-single-action-potential recording stimulation with cell-type specificity. Optical functional imaging optogenetics are delegated today primarily to large expensive microscopes based on free-space optics. Integrating the microscope functionality into an implantable form factor remains elusive goal. As a first step towards developing such device, variety...
One of the goals neuroengineering is to establish high-bandwidth, fully implantable, and minimally invasive wireless neural interfaces that help interrogate circuits in freely moving socially behaving animals. Optical offer advantages over electrophysiological techniques such as cell-type specificity, low cross-talk bidirectionality, wide field-of-view (FoV). While most optical to-date have taken form bulky "mini-scopes", recent advances shown promise achieving high-resolution,...
Next-generation brain–computer interfaces (BCIs) for healthy individuals are expected to largely rely on noninvasive functional imaging methods record cortex-wide neural activity because of the risk associated with surgically implanted devices. In this work, we present a fully integrated <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$1.8 \times 1.8$ </tex-math></inline-formula> mm single chip that can be...
This paper reports an implantable 3D imager for time-gated fluorescence imaging in the deep brain. Fluorescence excitation is provided by dual ns-pulsed blue micro-light-emitting diodes (μLED), and emission collected 8-by64 single-photon avalanche diode (SPAD) array, together packaged to a width of 420 μm allow insertion through cannula. Each SPAD masked repeating pattern Talbot gratings that give each pixel different angular sensitivity, allowing three-dimensional image reconstruction...
We demonstrate a fully implantable optoelectronic neural interface device featuring an array of single-photon avalanche photodiode (SPAD) detectors with global shutter and monolithically integrated flip-chip bonded micro-LEDs (µLED) for fluorescence excitation optogenetic stimulation. The is optical filters lensless computation mask to create 200-µm-thick device. To enable the shutter, area-efficient 10b roll-over counter used in-pixel. With phase unwrapping algorithm, these counters can be...
Next-generation brain-computer interfaces (BCI) for healthy individuals largely rely on non-invasive functional imaging methods to record cortex-wide neural activity because of the risk associated with surgically implanted devices. Near-infrared (NIR) time-domain diffuse optical tomography (TD-DOT) is a promising approach which relies reduced scattering and absorption human skull brain tissue in NIR spectrum [1]. In TD-DOT imaging, time-of-flight (ToF) scattered photons measured, improving...