A5049297931- Analytical Chemistry and Sensors
- Neuroscience and Neural Engineering
- Advanced Chemical Sensor Technologies
- Gas Sensing Nanomaterials and Sensors
- Microfluidic and Bio-sensing Technologies
- Microfluidic and Capillary Electrophoresis Applications
- Photoreceptor and optogenetics research
- Neural dynamics and brain function
- Air Quality Monitoring and Forecasting
- Biosensors and Analytical Detection
- Biomedical and Engineering Education
- EEG and Brain-Computer Interfaces
- Wireless Body Area Networks
- Electrochemical Analysis and Applications
- Analog and Mixed-Signal Circuit Design
- Molecular Communication and Nanonetworks
- Smart Agriculture and AI
- Quantum Information and Cryptography
- Air Quality and Health Impacts
- Optical Imaging and Spectroscopy Techniques
- Quantum Mechanics and Applications
- Image Processing Techniques and Applications
- Antenna Design and Optimization
- Neural Networks and Reservoir Computing
- Acoustic Wave Resonator Technologies
Columbia University
2022-2024
New York Proton Center
2023
Michigan State University
2016-2021
Shandong University
2012
Tsinghua University
2012
Abstract Minimally invasive, high-bandwidth brain-computer-interface (BCI) devices can revolutionize human applications. With orders-of-magnitude improvements in volumetric efficiency over other BCI technologies, we developed a 50-μm-thick, mechanically flexible micro-electrocorticography (μECoG) BCI, integrating 256×256 electrodes, signal processing, data telemetry, and wireless powering on single complementary metal-oxide-semiconductor (CMOS) substrate containing 65,536 recording 16,384...
Optical neurotechnologies use light to interface with neurons and can monitor manipulate neural activity high spatial-temporal precision over large cortical extents. While there has been significant progress in miniaturizing microscope for head-mounted configurations, these existing devices are still very bulky could never be fully implanted. Any viable translation of technologies human will require a much more noninvasive, implantable form factor. Here, we leverage advances microelectronics...
The integration of biosensors, microfluidics, and CMOS instrumentation provides a compact lab-on-CMOS microsystem well suited for high throughput measurement. This paper describes new epoxy chip-in-carrier process two planar metalization techniques that enable on-CMOS electrochemical measurement with multichannel microfluidics. Several design approaches different fabrication steps materials were experimentally analyzed to identify an ideal can achieve desired capability yield low material...
To non-invasively monitor personal biological and environmental samples in Internet of Things (IoT)-based wearable microfluidic sensing applications, the particle size could be key to sensing, which emphasizes need for fractionation. Deterministic lateral displacement (DLD) is a structure that has shown great potential fractionation micro- nano-sized particles. This paper introduces new externally balanced multi-section cascade DLD approach with section-scaling technique aimed at expanding...
The growing demand for personal healthcare monitoring requires a challenging combination of performance, size, power, and cost that is difficult to achieve with existing gas sensor technologies. This paper presents new CMOS monolithic microsystem meets these requirements through unique electrochemical readout circuits, post-CMOS planar electrodes, room temperature ionic liquid (RTIL) sensing materials. architecture design the CMOS-RTIL-based are described. device occupies less than 0.5mm2...
In article number 2007764, Changyong Cao and co-workers review the progress in smart agriculture systems, consisting of soil sensors, plant wearables, remote sensing devices, for detecting health condition crops to advance management modern farms increase production, while protecting environment.
This paper introduces a novel compact low-power amperometric instrumentation design with current-to-digital output for electrochemical sensors. By incorporating the double layer capacitance of an sensor's impedance model, our new can maintain performance while dramatically reducing circuit complexity and size. Electrochemical experiments potassium ferricyanide show that is in good agreement results obtained using commercial instrumentation. A high level linearity (R <sup...
A novel photon-number-resolving detector based on serially connected superconducting nanowires is presented. The serial nanowire (SND) uses spatial multiplexing a subwavelength scale, the same as parallel (PND), to provide an output signal proportional number of incident photons and avoids problem leakage current that PND suffers from, thus allowing both high quantum efficiency large resolvable photons. Electrothermal simulation results SND exhibit better linearity than PND, influence some...
Airborne particulate matter (PM) pollution, especially fine particles with a diameter of 2.5 μm or smaller (PM2.5), has caused severe air quality issues that threaten human life and contribute to global mortality. Thus low cost, portable wearable platform for individual PM2.5 monitoring is great interest. This paper introduces real-time combines particle separation microfluidic channel electrochemical detection. The device utilizes an I-shape pillar based deterministic lateral displacement...
The integration of biosensors, microfluidics and CMOS instrumentation provides a compact lab-on-CMOS microsystem well suited for high throughput measurement. This paper describes screen-printed planar metallization technique that overcomes challenges associated with traditional thin film metallization. Utilizing chip-in-carrier packaging approach an epoxy carrier, electrical interconnects are shown to reliably resolve up 10μm step height differences between the chip surrounding carrier...
The growing impact of airborne pollutants and explosive gases on human health occupational safety has escalated the demand for sensors to monitor hazardous gases. Existing gas lack miniaturization real-time measurement capability necessary quantify point-of-care exposure gaseous hazards. To overcome these challenges enable cost-effective monitoring personal in local environments, this paper presents a robust microfabricated planar electrochemical sensor featuring room temperature ionic...
While bioelectronic devices hold great promise in revolutionizing medicine and healthcare, they also face numerous challenges that must be overcome (you can add some references from above here). This includes improving the longevity safety of these devices, ensuring their ethical use, compatibility with human body environment.
ECoG electrode arrays offer great potential for high-channel-count monitoring of large scale brain activity. However, scaling recording systems to high channel count is challenging due the silicon area demanded by coupling capacitors necessary DC offset voltage rejection. This paper presents a new approach reduce per-channel circuits introducing capacitor-embedded structure that implements within existing area. For proof concept, 4×4 array 8 pF electrodes was fabricated in 2mm × using...
Deterministic lateral displacement (DLD) devices have demonstrated great promise in separation of micro and nano-sized particles, with important applications biomedical research healthcare monitoring. This paper introduces a new cascaded multi-section DLD approach toward expanding the dynamic range particle sizes separated. A robust model has been developed to analyze design tradeoffs practical fabrication limits this approach. Results show that by cascading multiple sections increasingly...
One of the goals neuroengineering is to establish high-bandwidth, fully implantable, and minimally invasive wireless neural interfaces that help interrogate circuits in freely moving socially behaving animals. Optical offer advantages over electrophysiological techniques such as cell-type specificity, low cross-talk bidirectionality, wide field-of-view (FoV). While most optical to-date have taken form bulky "mini-scopes", recent advances shown promise achieving high-resolution,...
CMOS integration creates the possibility of rendering complex imaging systems into low-cost wearable form factors with potential to transform medicine through continuous monitoring in a point-of-care setting. The proven safety ultrasound, its efficacy soft-tissue imaging, and electronic systems-on-chip have independently led development active front-end ASICs for handheld ultrasound [1]–[4] passive mechanically flexible 2D transducer arrays tethered large external electronics [5]. In this...
Biotechnology, with its vast potential, is poised to revolutionize fields ranging from medicine and healthcare environmental sensing. Central this revolution are bio-interfaces, which include both electrical non-electrical interventions using wearables implants. These interfaces offer new avenues for monitoring interacting biological systems, thereby enhancing the capabilities of modern solutions. The adoption innovative design strategies crucial fully harnessing potential overcoming current...