A5038040266- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Renal cell carcinoma treatment
- Lymphoma Diagnosis and Treatment
- Aortic aneurysm repair treatments
- Machine Learning and Algorithms
- Renal and related cancers
- Bladder and Urothelial Cancer Treatments
- Complementary and Alternative Medicine Studies
- Infectious Aortic and Vascular Conditions
- Urological Disorders and Treatments
- Chronic Lymphocytic Leukemia Research
- Intestinal Malrotation and Obstruction Disorders
- Advanced Radiotherapy Techniques
- semigroups and automata theory
- Urologic and reproductive health conditions
- Education, Psychology, and Social Research
- Urinary and Genital Oncology Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Melanoma and MAPK Pathways
- Vascular Procedures and Complications
- Therapeutic Uses of Natural Elements
- Renal and Vascular Pathologies
- Colorectal Cancer Surgical Treatments
- CAR-T cell therapy research
Charles University
2008-2024
University Hospital Hradec Králové
2012-2024
Život90
2023
Université Grenoble Alpes
2015
Ocní klinika
2013
Kliniken Essen-Mitte
2011
Stanford University
1934
Great progress has recently been made in the treatment of metastatic renal cell carcinoma, including introduction nivolumab, an immune checkpoint inhibitor. Despite promising results, this brings a completely new spectrum adverse events, distinct from those experienced with small-molecule kinase inhibitors. Neurologic immune-related events may be serious and potentially life-threatening complications requiring immediate immunosuppressive therapy. Only few cases encephalitis induced by...
Objectives: To retrospectively compare late toxicity of conventional‐dose three‐dimensional conformal radiation therapy (3D‐CRT) and high‐dose intensity‐modulated (IMRT) for prostate cancer. Methods: A total 340 patients with T1‐3 cancer were treated 3D‐CRT ( n = 228) IMRT 112). The median follow‐up time was 5.9 years 3.0 years, respectively. prescription dose 70 Gy 78 IMRT. Late gastrointestinal (GI) genitourinary (GU) toxicities graded according to the Fox Chase modification Radiation...
Situs viscerum inversus totalis is a rare disorder presenting with complete transposition of thoracic and abdominal viscera. It associated certain organ anomalies, but it not predisposing factor to cholecystolithiasis. To date, fewer than 100 cholecystectomies in patients situs have been published worldwide. We report case 75-year-old woman referred our hospital pain the left hypochondrium. acute calculous cholecystitis were diagnosed successfully conservatively treated antibiotics. The...
The preferred treatment for acute cholecystitis is cholecystectomy, but patients with precluded general anesthesia due to critical illness or multiple medical comorbidities it not suitable. Cholecystostomy could be a minimally invasive therapeutic alternative.To retrospectively evaluate the indications, technical features, efficacy, complications, patients' development and relationships among monitored parameters of percutaneous computed tomography (CT)-guided cholecystostomies in cases find...
The standard radical treatment of renal cell carcinoma is surgical resection, but it not suitable for patients with serious medical comorbidities and solitary kidney tumors. Minimally invasive ablation techniques could be an appropriate therapeutic alternative.To retrospectively evaluate the technical success, mid-term long-term efficacy safety radiofrequency microwave in small tumors.Over course 10 years, 91 procedures 64 68 tumors, size 12-60 mm, were performed using only conscious...
Aim: To retrospectively evaluate the technical features, feasibility, efficacy, accuracy and appropriate complications of CT-guided biopsies mediastinal masses correlate them with anatomical relationships in mediastinum. Methods: Over course ten years, 81 percutaneous biopsy procedures 78 patients for tumors sizes 27 - 189 mm diameter (median length 57.5 mm) were performed using only local anesthesia. These interventions done under guidance computed tomography. The men 30 cases women 48...
An aggressive periaortic lymphoma could very rarely invade the aortic wall. We present a unique case of patient with symptomatic thoracic aneurysm and imminent rupture due to lymphoma, in which endovascular treatment using stent graft was applied. After stabilization aorta histological confirmation B-cell by computed tomography-guided biopsy, antilymphoma therapy initiated. Despite full treatment, died 12 months later.
Despite the undeniable ongoing development of cross-sectional imaging methods, not all focal liver lesions (FLLs) have a typical pattern. An image-guided biopsy using percutaneous approach might safely provide final histological diagnosis FLLs. We aimed to evaluate accuracy, efficiency, complication rate, technical features, and relationships between followed parameters computed tomography (CT)-guided biopsies FLLs retrospective approach.303 procedures in 295 patients were carried out with...
Background and objectives: For the treatment of chronic unilateral radicular syndrome, there are various methods including three minimally invasive computed tomography (CT)-guided methods, namely, pulsed radiofrequency (PRF), transforaminal oxygen ozone therapy (TFOOT), epidural steroid injection (TFESI). Despite this, it is still unclear which these best in terms pain reduction disability improvement. Therefore, purpose this study was to evaluate short long-term effectiveness by measuring...
To evaluate the accuracy, efficiency, complication rate, technical features, and relations among followed parameters of CT-guided percutaneous biopsies pelvic lesions. 140 in 136 patients for tumors, sizes 17-160 mm largest diameter, were carried out with probable tumorous process within ten years period. The women 77 cases men 59 cases, aged 21 to 87 years. lesions´ size varied from 17 160 diameter. In 135 (96.4%) results true positive or negative; only 5 procedures (3.6%) histologically...
Aims: To retrospectively evaluate the technical features, efficacy, accuracy, appropriate complications, and relationships among monitored parameters of computed tomography-guided biopsies retroperitoneum-located processes. Methods: From December 2008 to 2018, 208 percutaneous biopsy procedures for tumors, sized 14 - 190 mm in diameter (median size 57.5 mm), were performed on patients with suspected retroperitoneal tumorous process imaging examinations. The men 124 cases women 84 cases, aged...
Východiska: Možnosti adjuvantní léčby maligního melanomu se v posledních letech významně rozšířily.Na základě výsledků klinických studií byla do léčebných postupů postupně zařazena jak imunoterapie zastoupená checkpoint inhibitory (ipilimumab, pembrolizumab, nivolumab), tak u pacientů s prokázanou mutací BRAF genu i cílená terapie (dabrafenib plus trametinib).V ČR je současné době pro klinickou praxi reálně dostupný nivolumab a kombinovaná dabrafenibu trametinibem.Nicméně otázkou zůstává,...
Systemic targeted therapy options are commonly used in patients with metastatic renal cell carcinoma (mRCC). Histological verification is crucial for treatment of mRCC. Our aim was to evaluate an optimal location percutaneous computed tomography‑guided biopsy a diagnosis suspected A total 138 biopsies tumors ranging from 21 133 mm diameter (median, 72 mm) were carried out 134 mRCC over 5‑year period. The variable, kidney performed 77 cases (55.8%), and other localizations (retroperitoneum,...
A retrospective audit from a urological center focused on fistulas that directly connect with the treatment of gynecological malignancy. Ureteroarterial fistulas, i.e., pathological communication between ureter and artery, are discussed in more detail.
Tento přehledový článek poskytuje komplexní pohled na diagnostiku nádorů ledvin z perspektivy jednotlivých oborů, které se diagnostikou a léčbou zabývají (urologové, kliničtí onkologové, radiologové patologové). Diskutovány jsou strategie diagnostiky, možnosti léčby význam multidisciplinárního týmu pro optimalizaci výsledků pacientů s tumory mimo ledvinnou pánvičku.
The aim of the study was to retrospectively evaluate technical features, efficacy, accuracy, and relevant complications computed tomography-guided biopsies in various anatomical localizations when diagnosing indolent lymphoma transformations, relapses, duplicate malignant diseases or benign processes.From December 2007 2017, 81 percutaneous biopsy procedures 72 patients for tumors, sizes 17-232 mm diameter (median length: 39 mm), were performed with known lymphomas their clinical history....
To evaluate the influence of endovascular therapy ruptured abdominal or iliac aneurysms on total mortality.We analyzed mortality 40 patients from 2005 to 2009, when only surgical treatment was available. These results were compared with period 2010 2013, aneurysm repair (EVAR) assessed as first option in selected patients.During 37.5%. From 45 treated 28.9%. Open performed 35 (77.8%) and EVAR 10 (22.2%) patients. The 30-day 1-year rates group 0% 20%, respectively, rate 30% during follow-up...