A5083034937- Genetic factors in colorectal cancer
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Esophageal and GI Pathology
- Colorectal Cancer Treatments and Studies
- Biliary and Gastrointestinal Fistulas
- Gastrointestinal disorders and treatments
- Abdominal vascular conditions and treatments
- Clinical Nutrition and Gastroenterology
- Celiac Disease Research and Management
- Probiotics and Fermented Foods
- Inflammatory Bowel Disease
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal Bleeding Diagnosis and Treatment
- Foreign Body Medical Cases
- Mycobacterium research and diagnosis
- Microscopic Colitis
- Gut microbiota and health
- Cancer Genomics and Diagnostics
- Clostridium difficile and Clostridium perfringens research
- Child Nutrition and Feeding Issues
- Abdominal Surgery and Complications
- Diverticular Disease and Complications
- Metastasis and carcinoma case studies
- Digestive system and related health
University Hospital Hradec Králové
2015-2025
Charles University
2014-2025
Regional Museum and Gallery Jicin
2021
Genomac
2016
Military University Hospital Prague
2016
Ocní klinika
2016
Colorectal cancer (CRC) is the 3rd most common worldwide and Czech Republic has 6th highest incidence of CRC worldwide. Large intestinal microbiota play in its etiopathogenesis important role. Bacteriocins are proteins, produced by bacteria from Enterobacteriaceae family. The aim our prospective study was to assess colonization large mucosa Escherichia coli strains investigate their bacteriocin production.A total 30 consecutive patients with colorectal adenoma, CRA (17 men, 13 women, aged...
Časný karcinom žaludku je definován histopatologicky jako nádor, jehož lokální růst omezen na sliznici a submukózu. Koncepce časného karcinomu byla rozpracována již v 60. letech Japonsku současnosti široce akceptována. Je potřeba si uvědomit, že termín časný zahrnuje léze bez i s metastatickým postižením spádových lymfatických uzlin. Společnou charakteristikou příznivější prognóza ve srovnání pokročilým onemocněním. Úkolem endoskopisty první řadě nádor (prekancerózy) diagnostikovat...
Abstract Background Optimal therapy for colorectal carcinoma (CRC), a frequently diagnosed malignancy, does not exist. Some of colicins and microcins, ribosomally synthesized peptides by gramnegative bacteria, have shown significant biological activity specifically against different cancer cells in vitro vivo conditions. The aim this prospective study was to evaluate natural colicin microcin production large intestinal mucosal bacteria each stage neoplasia those with history neoplasia....
Background: Occurrence of gastric metastasis as the first symptom breast carcinoma with a long period latency before presentation primary is rare. Case Report: A patient lobular carcinoma, treated by neoadjuvant preoperative chemoradiotherapy and total gastrectomy, complete local control. Fourteen months after was discovered, radiotherapy, chemotherapy hormonal treatment response. Twenty-three diagnosis cancer multiple colorectal metastases from occurred, which were treatment. Eighty-six...
Objective. Inflammatory bowel disease (IBD) can be associated with hypercoagulable disorders. Aim of this single-center, prospective study was an in-depth evaluation acquired states in IBD patients. Methods. A total 110 patients Crohn's (CD) (aged 19–69; mean 40.5, median 38.5 years), 43 ulcerative colitis (UC) 17–72; 42, 36 and 30 controls were enrolled. Full blood count, serum C-reactive protein (CRP), proteins C S, activated (APC) resistance, thrombin–antithrombin complex (TAT), F1+F2...
Buried bumper syndrome is a major complication of percutaneous endoscopic gastrostomy (PEG), in which the inner PEG tube migrates to become embedded stomach wall. Several strategies have been proposed for releasing bumper, based on: external traction [1], [2], pressure [3] and dissection overgrowing tissue using needle-knife [4], argon plasma coagulation, or dilation balloon [5].
AIM:To compare molecular profiles of proximal colon, distal colon and rectum in large adenomas, early late carcinomas.To assess feasibility testing directed at markers from this study routine clinical practice. METHODS:A prospective 3-year has resulted the acquisition samples 159 adenomas 138 carcinomas along with associated parameters including localization, grade histological type for localization stage carcinomas.A complex phenotyping been performed using multiplex ligation-dependent...
The ingestion of a button-type battery cell by child is an indication for urgent extraction (within 2 hours) if it has impacted in the esophagus because risks major or even fatal complications, such as perforation and bleeding. In contrast, cylindrical-type that passes into stomach not acute long causing symptoms. A follow-up radiograph after 4-day interval considered to be sufficient [1] [2].
Despite the undeniable ongoing development of cross-sectional imaging methods, not all focal liver lesions (FLLs) have a typical pattern. An image-guided biopsy using percutaneous approach might safely provide final histological diagnosis FLLs. We aimed to evaluate accuracy, efficiency, complication rate, technical features, and relationships between followed parameters computed tomography (CT)-guided biopsies FLLs retrospective approach.303 procedures in 295 patients were carried out with...
A 59-year-old woman with low-grade mucosa-associated lymphoid tissue (MALT) lymphoma of the colon was referred for follow-up endoscopy, which performed a colonoscope equipped autofluorescence imaging (AFI) and narrow-band (NBI) functions (Olympus Evis Lucera; CF FH260AZL/I). Several small flat lesions were seen during otherwise normal colonoscopy. The minimally elevated, slightly reddish, less than 5 mm in diameter; submucosal vascular pattern blurred, but covering mucosa appeared glossy...
Pneumatosis cystoides intestinalis (PCI), that is, presence of gas within the colonic wall, often has a polypoid appearance and can thus cause diagnostic uncertainty for endoscopist [1] [2] [3].
Cytomegalovirus enterocolitis is a rare but potentially life threatening complication after allogeneic stem cell transplantation. Its early diagnosis and treatment are essential for successful outcome.To determine the potential benefit of fecal CMV DNA detection in colitis among transplant recipients.Biopsies from lower gastrointestinal tract, taken during 69 episodes diarrhea, were compared with samples previously examined 45 patients transplantation.Six confirmed cases observed, 16 out...
642 Background: Patients with advanced stages of colorectal cancer have elevated levels circulating-tumor DNA (ctDNA) in peripheral blood. Its presence can facilitate acquisition material for tumor molecular profiling without the invasive procedures. In this work we present utility ctDNA determination phenotype within basic division into mutator (microsatellite instability, MSI and chromosomal CIN) or methylator (CpG island phenotype, CIMP). Methods: Tumor biopsy tissue 5mL blood samples...