A5027177588- Pharmaceutical studies and practices
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Pharmaceutical Practices and Patient Outcomes
- SARS-CoV-2 and COVID-19 Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Blood disorders and treatments
- Immunodeficiency and Autoimmune Disorders
- Medication Adherence and Compliance
- Pneumonia and Respiratory Infections
- Antibiotics Pharmacokinetics and Efficacy
- Diabetes Management and Research
- Actinomycetales infections and treatment
- Biomedical and Engineering Education
- Treatment of Major Depression
- Drug-Induced Adverse Reactions
- Pituitary Gland Disorders and Treatments
- Surgical Sutures and Adhesives
- Biomedical Ethics and Regulation
- Medical Practices and Rehabilitation
- Antibiotic Use and Resistance
- COVID-19 Impact on Reproduction
- Antibiotic Resistance in Bacteria
- CAR-T cell therapy research
University Hospital Hradec Králové
2020-2024
Charles University
2020-2024
University of Hradec Králové
2024
Several clinical trials have proved the efficacy and safety of T-cells chimeric antigen receptor (CAR-T cells) in treatment malignant lymphoma first products were registered European Union 2018. The shelf-life CAR-T cell liquid state is short, so cryopreservation offers a significant benefit for logistics manufacturing patient management. Direct shipment cryopreserved therapy to department feasible, nevertheless, intermediate storage hospital cryostorage facility gives advantage planning...
The objective of this study was to evaluate off-label high-dose ceftazidime population pharmacokinetics in cancer patients with suspected or proven extensively drug-resistant (XDR) Pseudomonas aeruginosa infections and then compare the achievement pharmacokinetic/pharmacodynamic (PK/PD) target after standard regimens using model-based simulations. A further aim clinically observe occurrence adverse effects during treatment.In treated (3 g every 6 h), blood samples were collected serum levels...
Abstract Despite lower virulence, the omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes disease 2019 (COVID-19) still poses a relevant threat for immunocompromised patients. A retrospective multicentric study was conducted to evaluate efficacy pre-exposure prophylaxis with tixagevimab/cilgavimab (Evusheld) 6-month follow-up preventing COVID-19 in adult patients hematology malignancy. Among 606 cohort, 96 (16%) contracted median 98.5 days after...
<h3>Background and Importance</h3> Optimisation of antibiotic (ATB) administration is vital for improving infection treatment effectiveness. An ATB stewardship programme can help clinicians rationalise prescribing. There no simple effective tool. Last year we conducted an adherence audit with the local guidelines (LG). <h3>Aim Objectives</h3> This study aimed to review LG in terms prescribing administration. <h3>Material Methods</h3> Single-centre prospective prescribed at least 50...
<h3>Background and Importance</h3> According to the global recommendations for COVID-19 therapy, adult patients at risk of severe disease (including after organ transplantation) should be treated with antivirals: preferably nirmatrelvir/ritonavir (Paxlovid) or remdesivir (Veklury). Alternative choice is unlicensed use molnupiravir (Lagevrio). <h3>Aim Objectives</h3> Our study focused on evaluating effectiveness safety in successful kidney transplantation (KTx). <h3>Material Methods</h3> A...
<h3>Introduction</h3> Evidence-based (EB) data on drug dosage optimization in children are already available across Europe. However, their systematic translation was lacking the Czech Republic and Slovakia. The purpose of our project is to create a database (CzechPharmPed) based evidence existing international databases national specifics, that will have positive impact daily clinical practice. objectification this crucial, moreover, provides valuable feedback. <h3>Methododology</h3> After...
Hairy cell leukemia (HCL) is a rare indolent lymphoproliferative disease with an accumulation of mature B lymphocytes fine reticular chromatin and cytoplasm typical hairy-like cytoplasmic projections. Rarely, hairy manifests as lung infiltration. The differential diagnosis between infection malignant involvement often challenging in such situations.We present 53-year-old female uncommon pulmonary leukemia. In addition, we discuss the complicated patients treatment approach to these...
Abstract High doses of corticosteroids in combination with rituximab remain an alternative the treatment relapsed or refractory chronic lymphocytic leukaemia (CLL) current era targeted therapies. This study retrospectively evaluates efficacy RCD (rituximab, cyclophosphamide and dexamethasone) regimen 51 patients CLL (median age, 72 years). Unfavourable prognostic features, such as Rai stage III/IV, unmutated IGHV, del11q, TP53 mutation/deletion, complex karyotype bulky lymphadenopathy, were...
Kyselina mravenčí byla pro svoje leptavé účinky v 10-90% koncentraci používána jako jedna z metod léčby virových bradavic.Přestože je dnešní době tato léčba považována za metodu obsolentní (pro možnost vzniku iritační dermatitidy, rizika poleptání a nekrózy s následnou jizvou), stále se touto praxí dermatologických ordinacích setkáváme.Autoři referují dvě kazuistiky kojenců, jejichž společnou příčinou nešťastná záměna lékovek při perorálním podání léčiva
Metamizol (dipyron) je v klinické praxi využíván již téměř 100 let jako neopioidní analgetikum se spasmolytickou účinností (zejména vyšší dávky) perioperační léčbě bolesti a antipyretikum druhé volby.Vykazuje dobrý profil nežádoucích účinků, mírné protidestičkové gastrointestinální nežádoucí účinky.Metamizol kontroverzní pro výskyt velmi vzácné idiosynkratické imunologicky podmíněné reakce na úrovni krvetvorby.Tam, kde metamizol používán, jsou účinky agranulocytózy granulocytopenie i nadále...
Oddělení klinické farmacie, Nemocniční
<h3>Background and Importance</h3> At height of COVID-19 pandemic surge delta variant, monoclonal antibodies became a vital treatment option for SARS-COV-2 positive outpatients at high risk severe disease progression. Casirivimab imdevimab (C/I) were used under EMA emergency use authorisation (EUA) there was paucity real-world data on safety effectiveness. <h3>Aim Objectives</h3> The study aimed to describe drug safety, self-reported symptom burden vaccination status in within 90 days...
Introduction Evidence-based (EB) data on various medicaments and safe drug dosing in pediatric population are already available across Europe. However, their systematic translation clear processing lacking daily clinical practice the Czech Republic. The purpose of our work is development a database similar to some existing internationally based formulary lists. Methods A approach recommended dosages drugs used environment, all compiled language. active substances will be arranged according...
ChronickĂĄ lymfocytĂĄrnĂ leukemie (CLL) je nejÄastÄjĹĄĂ leukemiĂ dospÄlĂ˝ch v euroamerickĂŠ populaci a bĂ˝vĂĄ Äasto komplikovĂĄna autoimunitnĂmi cytopeniemi. U nemocnĂ˝ch s anĂŠmiĂ trombocytopeniĂ jsou jednou z moĹžnĂ˝ch pĹĂÄin autoimunitnĂ hemolytickĂĄ anĂŠmie (AIHA) imunitnĂ trombocytopenie (ITP), vzĂĄcnÄ takĂŠ ÄistĂĄ aplĂĄzie ÄervenĂŠ Ĺady (PRCA). PoslednĂch nÄkolik let mĂĄme pĹi lĂŠÄbÄ CLL k dispozici novĂŠ cĂlenĂŠ perorĂĄlnĂ inhibitory, jejichĹž pouĹžitĂ...