A randomized, double-blind, placebo-controlled study was conducted to evaluate if Lactobacillus helveticus Lafti L10 (Lallemand Health Solutions, Montreal, Que., Canada) supplementation during 14 weeks in winter can influence the duration, severity, and incidence of upper respiratory tract illness (URTI), as well monitor different immune parameters population elite athletes. Before after treatment, cardiopulmonary testing self-rated state moods evaluation (by Profile Mood States...

A randomized, double-blind, placebo-controlled study was conducted, in order to evaluate if Lactobacillus helveticus Lafti® L10 (Lallemand Health Solutions, Montreal, Canada) supplementation during three months could influence oxidative markers the population of elite athletes: triathletes, cyclists and endurance athletes. Twenty-two athletes were randomized either placebo (n = 12) or probiotic 10) groups. The group received 2x1010 colony forming units L10. Before after serum samples...

Abstract Michalickova, DM, Kostic-Vucicevic, MM, Vukasinovic-Vesic, MD, Stojmenovic, TB, Dikic, NV, Andjelkovic, MS, Djordjevic, BI, Tanaskovic, BP, and Minic, RD. Lactobacillus helveticus Lafti L10 supplementation modulates mucosal humoral immunity in elite athletes: a randomized, double-blind, placebo-controlled trial. J Strength Cond Res 31(1): 62–70, 2017—To test the influence of probiotic on immune response, trial was conducted. Thirty athletes (24 males 6 females, females: V̇ o 2 max...

The aim of this study was to evaluate therapeutic potential edaravone in the murine model multiple sclerosis, experimental autoimmune encephalomyelitis (EAE) and expand knowledge its mechanism action. Edaravone (6 mg/kg/day) administered intraperitoneally from onset clinical symptoms until end experiment (28 days). Disease progression assessed daily using severity scores. At peak disease, histological analyses, markers oxidative stress (OS) parameters mitochondrial function brains spinal...

Peritonitis is a limiting complication of peritoneal dialysis, which treated by intraperitoneal administration antibiotics. Various dosing strategies are recommended for intraperitoneally administered vancomycin, leads to large differences in vancomycin exposure. Based on data from therapeutic drug monitoring, we developed the first-ever population pharmacokinetic model evaluate and plasma exposure after schedules International Society Peritoneal Dialysis. According our model, currently lead...

This study aimed to characterize the impact of extracorporeal membrane oxygenation (ECMO) on pharmacokinetics (PK) meropenem in neonates and children provide recommendations for dosing this specific population patients. Therapeutic drug monitoring (152 plasma concentrations) data from 45 patients (38 received ECMO) with a body weight (BW) 7.88 (3.62–11.97) kg (median (interquartile range)) postnatal age 3 (0–465) days were collected. The PK analysis was performed using NONMEM V7.3.0. Monte...

Objectives: This study characterizes the changes in pharmacokinetics of phenobarbital associated with extracorporeal membrane oxygenation treatment neonates, to illustrate our findings and provide guidance on dosing. Design: Retrospective pilot population pharmacokinetic analysis. Setting: Neonatal ICU. Patients: Thirteen critically ill neonates (birth body weight, 3.21 kg [2.65–3.72 kg]; postnatal age at start treatment: 2 d [0–7 d]; gestational age: 38 wk [38–41 wk]) receiving venovenous...

The aim of this prospective PK study was to evaluate the pharmacokinetics ciprofloxacin dosed within first 36 h (early phase) and after 3 days treatment (delayed using individual population analysis. secondary possible dosing implications observed differences between early delayed phases achieve a PK/PD target for AUC24/MIC ≥ 125. Blood concentrations (1 4 dose trough) were monitored in critically ill adults treatment. Individual analyses performed. Complete concentration-time profiles...

The objective of this study was to evaluate off-label high-dose ceftazidime population pharmacokinetics in cancer patients with suspected or proven extensively drug-resistant (XDR) Pseudomonas aeruginosa infections and then compare the achievement pharmacokinetic/pharmacodynamic (PK/PD) target after standard regimens using model-based simulations. A further aim clinically observe occurrence adverse effects during treatment.In treated (3 g every 6 h), blood samples were collected serum levels...

Abstract Michalickova, D, Minic, R, Kotur-Stevuljevic, J, Andjelkovic, M, Dikic, N, Kostic-Vucicevic, Slanar, O, and Djordjevic, B. Changes in parameters of oxidative stress, immunity, behavior endurance athletes during a preparation period winter. J Strength Cond Res 34(10): 2965–2973, 2020—The current study monitored markers immunological status 9 male elite athletes: V̇ o 2 max: 68 ± 11 ml·kg −1 ·min , age: 24 2.5 years, training loads: 128 21 metabolic equivalents-h·wk 3-month winter...

The goal of this work was to elucidate similarities between microorganisms from the perspective humoral immune system reactivity in professional athletes. serum IgG 14 young, individuals analyzed 23 selected as antigens by use house ELISA. Serum IgM and IgA also a control group sex age matched used for comparison. obtained absorbance levels were string values correlate different microorganisms. found be most cross reactive antibody class, Pearson's r = 0.7–0.92, very distant bacterial...

The neuropeptide galanin is a widely distributed neurotransmitter/neuromodulator that regulates variety of physiological processes and also participates in the regulation stress responses. aims present study were to investigate expression receptors (GalR1, GalR2, GalR3) spinal cords murine model multiple sclerosis, experimental autoimmune encephalomyelitis (EAE) using qPCR analysis determine GalR1 cellular localization (oligodendrocytes, microglia, astrocytes, ependymal cells, endothelial...

The aim of this study was to describe and quantify pharmacokinetics ampicillin used prophylactically in cardiac surgery both with without cardiopulmonary bypass (CPB) using population pharmacokinetic analysis order propose an optimal dosing strategy. Adult patients undergoing treated prophylactic dose 2 g were enrolled prospective study. Blood samples collected according the protocol plasma concentrations measured HPLC/UV system. A three-stage model nonlinear mixed-effects modelling approach...

Background Caffeine and taurine are widely used as ergogenic aids in the population of professional athletes. However, recent years their use general is becoming popular. There increased number energy drinks dietary products on market which contain these substances. The aim Declared caffeine content often do not coincide with actual amounts that found products. Therefore, it necessary to determine consumed products, well evaluate intake physiologically active Methodes This paper presents...

The objectives of this study were to develop a population pharmacokinetic model prophylactically administered cefazolin in patients undergoing cardiac surgery with and without the use cardiopulmonary bypass both existing types—standard (ECC) minimallyu invasive extracorporeal circulation (MiECC)—and propose cefazoline dosing optimization based on model. A total 65 adult recruited clinical trial. prophylactic dose 2 g was intravenously before surgery. Blood samples collected using rich...

Pharmacokinetic data for riociguat in patients with chronic thromboembolic pulmonary hypertension (CTEPH) have previously been reported from randomized clinical trials, which may not fully reflect the population encountered routine practice. The aim of current study was to characterize pharmacokinetic and its metabolite M1 A model developed NONMEM 7.3, based on plasma concentrations 49 CTEPH. One sample available each patient obtained at different time points after last dose. Age,...

The post-mortem toxicological findings may be misinterpreted, if the drug undergoes substantial redistribution. As alprazolam is one of most frequently evaluated for legal/forensic reasons in drug-related fatalities, we studied possible changes distribution after death a rat model. Rats were sacrificed 30 minutes administration. Blood and tissue samples from 8 animals per sampling time collected at 0, 2, 6, 24 h death. experimental assayed using validated UHPLC-PDA method. Median blood...

BACKGROUND: The current study uses a population modeling approach to evaluate and quantify the impact of severity asphyxia hypoxic-ischemic encephalopathy (HIE) on pharmacokinetics phenobarbital in asphyxiated newborns treated with therapeutic hypothermia.METHODS: Included received (the TOBY trial protocol). 120 plasma sample were available from 50 newborns, median (IQR) weight 3.3 (2.8-3.5) kg gestational age 39 (39-40) weeks. NONMEM version 7.2® was used for data analysis. Age, body...