The characterized 10 Streptomyces isolates were previously selected by their abilities to solubilize phosphates. To investigate whether these represent multifaceted plant growth-promoting rhizobacteria (PGPR), potassium-solubilizing, auxin-producing and inhibitory activities determined. spp. yielded a variable biomass in the presence of insoluble orthoclase as sole potassium (K) source, indicating that they able extract different amounts K from this source for own growth. Three strains (AZ,...

Introduction Given their remarkable capacity to convert atmospheric nitrogen into plant-accessible ammonia, nitrogen-fixing microbial species hold promise as a sustainable alternative chemical fertilizers, particularly in economically significant crops like wheat. This study aimed identify strains with optimal attributes for promoting wheat growth sustainably, primary emphasis on reducing reliance fertilizers. Methods We isolated free from diverse rhizospheric soils across Morocco....

In the course of our research, aimed at improving sugar beets phosphorus nutrition, we isolated and characterized Streptomyces sp. strains, endemic from beet fields Beni-Mellal region, which are able to use natural rock phosphate (RP) tricalcium (TCP) as sole sources. Ten isolates yielded a comparable biomass in presence these two insoluble sources, indicating that they were extract similar amount (P) latter for their own growth. Interestingly, five strains released soluble P large excess...

SARS-CoV-2 has caused a huge pandemic affecting millions of people and resulting innumerous deaths. A better understanding the correlation between binding antibodies neutralizing is necessary to address protective immunity post-infection or vaccination. Here, we investigate humoral immune response seroprevalence following vaccination with adenovirus-based vector in 177 serum samples. Microneutralization (MN) assay was used as reference method assess whether antibody titers correlated...

The purpose of this work was to screen clinical isolates actinomycetes producing nonpolyenic antifungals. This choice made limit the problem rediscovery well-known antifungal families, especially polyenic One hundred and ten strains were tested, using two diffusion methods test media, against three yeast species filamentous fungi. Among 54 (49%) showing activity, five belonging genus Streptomyces active all organisms appeared promising. These results indicate that environmental could be an...

Multiresistant Staphylococcus capitis pulsotype NRCS-A has been reported to be a major pathogen causing nosocomial bacteremia in preterm infants. We report that the strain CR01 harbors novel 60.9-kb composite staphylococcal cassette chromosome mec (SCCmec) element, composed of an SCCmec with strong homologies aureus ST398 and SCCcad/ars/cop harboring resistance genes for cadmium, arsenic, copper. Whole-genome-based comparisons published S. strains suggest acquired two elements independently.

The multi-resistant Staphylococcus capitis clone NRCS-A has recently been described as a major pathogen causing nosocomial, late-onset sepsis (LOS) in preterm neonates worldwide. representatives exhibit an atypical antibiotic resistance profile. Here, the complete closed genome (chromosomal and plasmid sequences) of prototype strain CR01 draft genomes three other clinical strains from Australia, Belgium United Kingdom are annotated compared to available non-NRCS-A S. genomes. Our goal was...

Strain EB01T sp. nov. is the type strain of Bacillus massilioalgeriensis, a new species within genus Bacillus. This strain, whose genome described here, was isolated from sediment sample hypersaline lake Ezzemoul sabkha in northeastern Algeria. B. massilioalgeriensis facultative anaerobic Gram-positive bacillus. Here we describe features this organism, together with complete sequence and annotation. The 5,269,577 bp long contains 5,098 protein-coding 95 RNA genes, including 12 rRNA genes.

The taxonomic position of an actinomycete isolated from ultramafic soil in New Caledonia was determined using a polyphasic approach. isolate, which designated SFOp68 T , shown to have chemical and morphological properties typical streptomycetes. An almost complete 16S rRNA gene sequence the isolate generated compared with sequences representative data not only supported classification strain genus Streptomyces but also showed that it formed distinct phyletic line most closely related one...

Soil actinomycetes explorations appear to be an efficient alternative as biofertilizers optimize the use of phosphorus (P) resources and enhance plant growth. This research aimed explore distribution isolated from four different rhizospheric Moroccan oat soils investigate their potential for P solubilization. The was significantly more abundant in Settat (9.68%), Tangier (7.38%), Beni Mellal (6.87%) than Merchouch-Rabat (4.90%) region. A total 235 actinomycete strains were all sites tested...

Traditional antimicrobial antibiotics are increasingly suffering from the emergence of multidrug resistance among pathogenic microorganisms. The antibiotic era is threatened by ruthless rise in bacterial infections. A significant role these profiles attributed to efflux pumps. Hence, much effort being directed towards developing new compounds overcome this problem. During our screening program pumps inhibitors (EPI) produced bioactive Moroccan Actinobacteria, 210 isolates were screened for...

Staphylococcus capitis pulsotype NRCS-A was previously reported as a frequent cause of late-onset sepsis in neonatal intensive care units (NICUs) worldwide. Here, we report the whole-genome shotgun sequences four S. NCRS-A strains, CR03, CR04, CR05, and CR09, isolated from Belgium, Australia, United Kingdom, France, respectively.

Here, we report a complete genome sequence obtained for novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strain isolated from nasopharyngeal swab specimen of Moroccan patient with disease 2019 (COVID-19).

<h3>Background</h3> Multi-resistant <i>Staphylococcus capitis</i> NRCS-A is involved in late-onset sepsis (LOS) French NICUs. <h3>Aims</h3> To investigate the geographical distribution of NRCS-A, and to precise its susceptibility profile. <h3>Methods</h3> Twelve <i>S. isolates from distant NICUs (Australia, Belgium, France, United Kingdom, n = 3 each) 2 adult patients were analysed using PFGE, SCCmec typing, dru-typing, a MLST-like analysis, antimicrobial testing. explore impact vancomycin...

2-Benzenesulphinyl-(1,4)-naphtoquinone and 14 derivatives were synthesised used to evaluate their cytotoxicity against a human myelomonocyte cell line antifungal activity two yeast, i.e. Candida albicans C. tropicalis filamentous fungi such as Aspergillus niger Fusarium oxysporum one dermatophyte, namely Trichophyton tonsurans. The activities investigated in comparison with amphotericin B reference drug. No compound was significantly more toxic than at 0.2 microg ml(-1). best results of...

Gastrointestinal stromal tumors (GISTs), the most prevalent mesenchymal of gastrointestinal tract, are predominantly driven by activating mutations in receptor tyrosine kinases such as c-Kit and PDGFRα. Resistance to kinase inhibitors (TKIs) poses a substantial therapeutic challenge, underscoring need for novel treatments. Consequently, investigating potential natural compounds, specifically flavonoids from Retama monosperma, known their diverse bioactivities, is significant interest....

Mutations in the c-KIT or PDGFRα genes primarily drive gastrointestinal stromal tumors (GISTs). While tyrosine kinase inhibitors (TKIs) such as Imatinib have improved outcomes, resistance due to secondary mutations remains a significant challenge. This study used computational methods identify phytochemicals from Moroccan plants dual of and PDGFRα. Screening 545 phytochemicals, 6-Hydroxygenistein (6-OHG), derivative Genistein, showed high binding affinities (-10.3 kcal/mol for -10.5 c-KIT),...

Here, we report the draft genome sequences of methicillin-susceptible Staphylococcus captis pulsotype NCRS-C (CR02 strain) and multiresistant NCRS-A (CR07 strain).

In this research, we isolated and characterized Streptomyces strains, endemic from sugar beet fields of the Beni-Mellal region, able to use natural rock phosphate (RP) tricalcium (TCP), as sole source. Ten isolates yielded a comparable biomass in presence these two insoluble sources, indicating that they were extract similar amount phosphorus (P) latter for their own growth. Interestingly, five strains released soluble P large excess TCP culture broth whereas only BP, related bellus BYC,...