Objectives Modification of the electrode placement with electroconvulsive therapy (ECT) impacts on patient outcomes, including cognitive effects. The investigation alternative right unilateral placements (RUL) has potential to further improve ECT outcomes by reducing side Methods This study investigated differences in intracerebral distribution current density comparing standard d'Elia positioning (temporoparietal [TP]) two recently developed RUL placements, focal electrically administered...

Computational models have become essential in predicting medical device efficacy prior to clinical studies. To investigate the performance of a left-ventricular assist (LVAD), fully-coupled cardiac fluid-electromechanics finite element model was developed, incorporating electrical activation, passive and active myocardial mechanics, as well blood hemodynamics solved simultaneously an idealized biventricular geometry. Electrical activation initiated using simplified Purkinje network with...

Obesity is a common comorbidity of chronic obstructive pulmonary disease (COPD) and has been associated with worse outcomes. However, it unknown whether the interaction between obesity COPD modulates diaphragm shape consequently its function. The body mass index (BMI) used as correlate obesity. We tested hypothesis that muscle size ring insertion in non-COPD subjects are modulated by BMI. recruited 48 patients postbronchiodilator forced expiratory volume 1 s (FEV1)-to-forced vital capacity...

Demands for better control of the operating conditions used in human motion tracking and medical applications have led to need means detecting different types proprioceptive activity patterns. The purpose this paper is propose development a sensor system therapy assessment using cotton fabric-based flexible microelectromechanical systems (MEMS). To demonstrate application sensor, has been developed order detect finger flexion movements on joint. procedure MEMS fabricated fabric as structural...

BackgroundThe electrode placement and pulse width for electroconvulsive therapy (ECT) are important treatment parameters associated with ECT related retrograde memory side-effects. Modification of these right unilateral (RUL) may have utility further reducing side-effects.ObjectiveThis study explored use the frontoparietal (FP) side effects ECT. We hypothesised that superior outcomes would occur FP compared to temporoparietal (TP) ultrabrief (UB: 0.3 ms) brief (BP: 1.0 ECT.MethodsIn this...

Flow energetics have been proposed as early indicators of progressive left ventricular (LV) functional impairment in patients with myocardial infarction (MI), but its correlation individual MI parameters has not fully explored. Using electro-fluid-structure interaction LV models, this study investigated the between four parameters: infarct size, multiplicity, regional enhancement contractility at viable myocardium area (RECVM), and mechanical dyssynchrony (LVMD) intraventricular vortex flow...

Myocardial infarction (MI) is the most common cause of a heart failure, which occurs due to myocardial ischemia leading left ventricular (LV) remodeling. LV remodeling particularly at ischemic area and region surrounds it, known as border zone. The role zone in initiating process urges investigation on correlation between early changes outcome. Thus, this study aims simulate preliminary conceptual work formation evolution during onset MI its effect towards processes by incorporating oxygen...

Action potential propagation in cardiac tissue is mainly governed by highly resistive gap junctions, which causes the to behave as a network of active cell nodes interconnected resistors. This property action be less dependent on level mechanical deformation. study proposes that electrical conductivity electromechanical simulations should held fixed relative material frame, reproducing dominant effect intercellular junctions resistance instead more commonly employed spatial frame. Our showed...

We present a fully-coupled fluid-electromechanics model of the heart using generic biventricular structure to provide tool for future multiphysics interaction studies. A simplified Purkinje fibre was embedded within myocardium along with transmural variation action potential duration obtain realistic activation and relaxation sequences. To ease computational requirements, phenomenological excitation-contraction formulations were chosen, coupled transverse isotropic hyperelastic myocardial...

Continued demands for better control of the operating conditions used in human motion tracking and medical applications have led to need means detecting different types proprioceptive activity pattern. One way satisfy this is use MEMS technology develop a sensor which can be later rehabilitation treatment patients monitoring. The purpose paper provide an overview development textile-based system therapy assessment by Micro Electro Mechanical Systems (MEMS) technologies. To demonstrate...

This paper describes the developments of Bio-MEMS using fabric as structural components. The use fabrics for construction significantly simplifies conventional fabrication process. In this we proposed a new process fabrics-based Bio-MEMS. addition, to simple and low-cost process, stamping method offers number advantages which is less complicated procedure steps during result reducing time amount nanomaterial used. We demonstrate gauge factor 7.424 are results in higher sensitivity. By...

Introduction Electroconvulsive therapy (ECT) is effective in treating severe depression and other neuropsychiatric disorders, but how the presence of an anatomical anomaly affects electrical pathways between electrodes remains unclear. We investigate difference electric field (E-field) distribution during ECT brain a patient with arachnoid cyst relative to hypothetical condition where was not present. Methods Magnetic resonance imaging scans head large left frontal were segmented construct...

Ventricular remodeling after myocardial infarction increases the rate of mortality and is highly associated with extent infarct transmurality. It hypothesized that stiffness alters regional mechanics affects likelihood human ventricular remodeling. However, this yet to be studied in detail. In paper, we present simulations from an actively-contracting left model investigate effects transmural on myofiber mechanics. Results show higher reduces systolic stress at border zones, minimizing...

Blood flow reduction to the myocardium could result in myocardial ischemia. This also caused severe electrophysiological changes that eventually lead development of lethal cardiac arrhythmias. To understand ischemic event and its association with arrythmia, mathematical modeling electrophysiology has been widely used various effects important relations between parameters have obtained. However, date, effect oxygen metabolism arrhythmia formation not well studied. Moreover, no detailed...

Myocardial infarction (MI) is the common cause of heart failure, which happens following a myocardial ischemia. Left ventricular (LV) remodeling has been associated with long-term outcomes MI. The infarct region growing and becoming stiffen over time as result remodeling, causing LV to weaken dilate. However, evolution growth starting from shortage oxygen supply have not extensively studied, thus further work involving complete cardiac cycle required study progressive effect ischemic changes...