A5003609720- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Oral health in cancer treatment
- Alzheimer's disease research and treatments
- Pregnancy and preeclampsia studies
- Mosquito-borne diseases and control
- Beetle Biology and Toxicology Studies
- Extracellular vesicles in disease
- Oral Health Pathology and Treatment
- Cervical Cancer and HPV Research
- Bacterial Genetics and Biotechnology
- Bioinformatics and Genomic Networks
- Viral Infections and Vectors
- Melanoma and MAPK Pathways
- Ferroptosis and cancer prognosis
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Laser Applications in Dentistry and Medicine
Leipzig University
2021-2024
Fundação Oswaldo Cruz
2017-2021
Instituto Nacional do Câncer
2012-2020
Fundação Carlos Chagas
2018
Abstract Background Interaction between malignant cells and immune that reside within the tumor microenvironment (TME) modulate different aspects of development progression. Recent works showed importance miRNA-containing extracellular vesicles in this crosstalk. Methods Interested understanding interplay melanoma immune-related TME cells, we characterized TCGA’s metastatic samples according to their profiles, HLA-I neoepitopes, transcriptome profile classified them into three groups....
Lung cancer is one of the most frequent types worldwide. Most patients are diagnosed at advanced stage and thus have poor prognosis. Smoking a risk factor for lung cancer, however smokers do not develop while 20% women with adenocarcinoma non-smokers. Therefore, it possible that these two groups present differences besides smoking status, including in their gene expression signature. The altered patterns non-coding RNAs complex diseases make them potential biomarkers diagnosis treatment. We...
Abstract Riboswitches are RNA sensors that affect post-transcriptional processes through their ability to bind small molecules. Thiamine pyrophosphate (TPP) riboswitch class is the most widespread occurring in all three domains of life. Even though it controls different genes involved synthesis or transport thiamine and its phosphorylated derivatives bacteria, archaea, fungi, plants, TPP aptamer has a conserved structure. In this study, we aimed at understanding differences structural...
Spliced leader dependent trans-splicing (SLTS) has been described as an important RNA regulatory process that occurs in different organisms, including the trematode Schistosoma mansoni. We identified more than seven thousand putative SLTS sites parasite, comprising genes with a wide spectrum of functional classes, which underlines ubiquitous mechanism parasite. Also, gene expression levels span several orders magnitude, showing frequency is not determined by level target gene, but presence...
Transcriptional profiling of hematopoietic cell subpopulations has helped to characterize the developmental stages system and molecular bases malignant non-malignant blood diseases. Previously, only genes targeted by expression microarrays could be profiled genome-wide. High-throughput RNA sequencing, however, encompasses a broader repertoire molecules, without restriction previously annotated genes. We analyzed BLUEPRINT consortium RNA-sequencing data for mature types. The comprised 90...
Squamous cell carcinoma (SCC) and adenocarcinoma (ADC) are the most common histological types of cervical cancer (CC). The worse prognosis ADC cases highlights need for better molecular characterization regarding differences between these CC types. RNA-Seq analysis seven SCC three human papillomavirus 16-positive samples comparison with public data from non-tumoral papillomavirus-negative tissue revealed pathways exclusive to each type, such as epithelial maintenance in maturity-onset...
The numerous genome sequencing projects produced unprecedented amount of data providing significant information to the discovery novel non-coding RNA (ncRNA). Several ncRNAs have been described control gene expression and display important role during cell differentiation homeostasis. In last decade, high throughput methods in conjunction with approaches bioinformatics used identify, classify, evaluate hundreds ncRNA normal pathological states, such as cancer. Patient outcomes already...
Colorectal cancer (CRC) is a heterogeneous cancer. Its treatment depends on its anatomical site and distinguishes between colon, rectum, rectosigmoid junction This study aimed to identify diagnostic prognostic biomarkers using networks of CRC-associated transcripts that can be built based competing endogenous RNAs (ceRNA).RNA expression clinical information data patients with were obtained from The Cancer Genome Atlas (TCGA). RNA profiles assessed through bioinformatics analysis, ceRNA was...
Abstract Transcriptional profiling of hematopoietic cell subpopulations has helped characterize the developmental stages system and molecular basis malignant non-malignant blood diseases for past three decades. The introduction high-throughput RNA sequencing increased knowledge full repertoire molecules in cells different types, without relying on prior gene annotation. Here, we introduce analysis BLUEPRINT consortium expression data mature cells, comprising 90 total 32 small experiments,...
Screening for genes differentially expressed in placental tissues, aiming to identify transcriptional signatures that may be involved ZIKV congenital pathogenesis.Transcriptome data from tissues of pregnant women naturally infected with Zika virus during the third trimester were compared those who tested negative infection. The findings validated using both a cell culture model and an immunohistochemistry/morphological analysis tissues.Transcriptome revealed infection induces downregulation...
Abstract Many publicly available databases provide disease related data, that makes it possible to link genomic data medical and meta-data. The cancer genome atlas (TCGA), for example, compiles tens of thousand datasets covering a wide array types. Here we introduce an interactive highly automatized TCGA-based workflow links analyses epigenomic transcriptomic with treatment survival in order identify biomarkers indicate success. TREMSUCS-TCGA is flexible respect type provides standard...
Abstract Alzheimer's disease (AD) is a progressive neurodegenerative disorder with typical neuropathological hallmarks, such as neuritic plaques and neurofibrillary tangles, preferentially found at layers III V. The distribution of both hallmarks provides the basis for staging AD, following hierarchical pattern throughout cerebral cortex. To unravel background this layer-specific vulnerability, we evaluated differential gene expression supragranular infragranular subcortical white matter in...