A5012052984- Neurogenesis and neuroplasticity mechanisms
- Multiple Sclerosis Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- Effects of Radiation Exposure
- Genetic and Kidney Cyst Diseases
- Autoimmune Neurological Disorders and Treatments
- Cerebrospinal fluid and hydrocephalus
- Systemic Lupus Erythematosus Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
Centre de Recherche en Neurosciences de Lyon
2020-2025
Inserm
2020-2025
Université Claude Bernard Lyon 1
2020-2025
Centre National de la Recherche Scientifique
2020-2025
Montreal Neurological Institute and Hospital
2023-2024
McGill University
2024
Abstract Ependymal cells form a specialized brain–cerebrospinal fluid (CSF) interface and regulate local CSF microcirculation. It is becoming increasingly recognized that ependymal assume reactive state in response to aging disease, including conditions involving hypoxia, hydrocephalus, neurodegeneration, neuroinflammation. Yet what transcriptional signatures govern these states whether this reactivity shares any similarities with classical descriptions of glial (i.e., astrocytes) remain...
Biomarkers for predicting myelin oligodendrocyte glycoprotein antibody (Ab)-associated disease (MOGAD) clinical course are still missing. Binding capacity to a mutant MOG protein variant (MOG-P42S; non-P42) was shown correlate with an increased relapse risk in adult patients.The objective of our study assess the frequency binding non-P42 cohort paediatric MOGAD and investigate its association specific profiles course. We included children MOG-Ab seropositive samples collected after their...
Neuromyelitis optica, a rare neuroinflammatory demyelinating disease of the CNS, is characterized by presence specific pathogenic autoantibodies directed against astrocytic water channel aquaporin 4 (AQP4) and now considered as an astrocytopathy associated either with complement-dependent astrocyte death or dysfunction. However, link between dysfunction demyelination remains unclear. We propose glial intercellular communication, supported connexin hemichannels gap junctions, to be involved...
Ependymal cells make up the epithelial monolayer that lines brain ventricles and spinal cord central canal are filled with cerebrospinal fluid. The ependyma has several functions, including regulating solute exchange between fluid parenchyma, controlling microcirculation of via coordinated ciliary beating, acting as a partial barrier. Dysregulation these functions can lead to waste clearance impairment, accumulation, hydrocephalus, more. A role for ependymal in variety neurological disorders...
Neuromyelitis optica (NMO) is an autoimmune demyelinating disease of the central nervous system characterized by presence autoantibodies (called NMO-IgG) targeting aquaporin-4. Aquaporin-4 expressed at perivascular foot processes astrocytes, in glia limitans, but also ependyma. Most studies have focused on studying pathogenicity NMO-IgG and NMO now considered astrocytopathy. However, periependymal lesions are observed suggesting that ependymal cells could be targeted NMO-IgG. Ependymal...