A5100387983- Anesthesia and Neurotoxicity Research
- Cardiac Ischemia and Reperfusion
- Intensive Care Unit Cognitive Disorders
- Organ Transplantation Techniques and Outcomes
- Anesthesia and Sedative Agents
- Anesthesia and Pain Management
- Pulmonary Hypertension Research and Treatments
- Pain Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Neurological Disease Mechanisms and Treatments
- Transplantation: Methods and Outcomes
- Nerve injury and regeneration
- Traumatic Brain Injury and Neurovascular Disturbances
- Nausea and vomiting management
- Neurobiology and Insect Physiology Research
- Pain Management and Opioid Use
- Cardiac, Anesthesia and Surgical Outcomes
- Physiological and biochemical adaptations
- Treatment of Major Depression
- Thermal Regulation in Medicine
- Zebrafish Biomedical Research Applications
- Maternal Mental Health During Pregnancy and Postpartum
- Neuropeptides and Animal Physiology
- Pharmacological Effects of Natural Compounds
- Cardiac Arrest and Resuscitation
Xuzhou Medical College
2009-2025
Nanjing Medical University
2011-2024
Singapore Institute of Manufacturing Technology
2015-2024
Agency for Science, Technology and Research
2024
Wuxi People's Hospital
2011-2021
University of California, San Diego
2010
Howard Hughes Medical Institute
2008
Duke University Hospital
2008
Duke Medical Center
2008
Duke University
2008
Abstract Background Postoperative cognitive dysfunction (POCD) is a postoperative complication of the central nervous system, especially in elderly patients. Growing evidence shows close relationship between kidney and cognition. This study aimed to evaluate subsequent risk POCD indicators related kidney. Methods A total 93 eligible patients (≥65 years old) undergoing elective hip replacement were enrolled. Before 1 day after surgery, blood samples collected from enrolled Mini‐Mental State...
Hepatic ischemia/reperfusion (IR) injury is a critical contraindication of hepatobiliary surgery and results in severe liver damage. It imperative to identify underlying pathophysiological mechanisms. In the current study, rat model IR was established explore mechanisms sevoflurane during surgical intervention on IR. The detection cytokines performed using ELISA reverse transcription-quantitative polymerase chain reaction western blot assays were used detect mRNA protein expression levels,...
Postpartum depression (PPD) is a serious mental health concern affecting approximately 17.22 % of new mothers worldwide. In addition to its obstetric effects, oxytocin (OXT) has also been considered play role in PPD. However, most previous studies exploring associations between PPD and OXT levels focus on easier accessible compartments such as blood or saliva. To explore the possible association levels, assess interaction peripheral secretion central release OXT. this study, we prospectively...
This study aims to evaluate the efficacy of esketamine on postoperative recovery quality after laparoscopic bariatric surgery. Patients (n = 74) scheduled for surgery were randomly divided into two groups: group (group E: 0.5 mg/kg/h infusion, i.e., 0.2 mL/kg/h) or control C: mL/kg/h normal saline infusion). The infusions stopped 20 min before end procedure. primary outcome was Quality Recovery-40 (QoR-40) score day 1 (POD 1). secondary outcomes included QoR-40 scores PODs 2 and 7, Numeric...
Focal adhesion kinase (FAK) is an important therapeutic target in pulmonary artery hypertension (PAH); however, the mechanism of its activation remains unknown. The present study aimed to investigate whether angiotensin‑converting enzyme 2 (ACE2) could regulate FAK and alleviate PAH a rat model established with single administration monocrotaline followed by continuous hypoxia treatment. In current study, right ventricular pressure, body weight hypertrophy index were measured,...
Opioid analgesics are the most common therapeutic analgesic for acute pain. In this study, toxicological and pharmacological features of a group opioid were characterized by motility human sperm. Aliquots sperm incubated with various concentrations in vitro. Computer-assisted analysis was used to assess at 15 minutes, 2 hours, 4 hours after drug addition medium. Butorphanol dezocine showed marked reduction incubation minutes. more effective than immobilizing Other opioids studied, such as...
Purpose: To investigate the effect of dexmedetomidine (Dex) in a rat ex vivo lung model ischemia-reperfusion injury. Methods: An IL-2 perfusion system was used to establish Drugs were added solution for reperfusion. Lung injury assessed by histopathological changes, airway pressure (Res), compliance (Compl), flow (Flow), pulmonary venous oxygen partial (PaO2), and wet/dry (W/D) weight ratio. The levels superoxide dismutase (SOD), malondialdehyde (MDA), 78 kDa glucose-regulated protein...
Objective: Despite the application of dexmedetomidine (DEX) as a perioperative adjuvant in local analgesia, exact analgesic mechanism underpinning chronic neuropathic pain (CNP) awaits our elucidation. Methods: We investigated molecular mechanisms anti-nociceptive effect DEX on mouse model induced by constriction injury (CCI). Results: administration significantly increased paw withdrawal latency (PWL) values 0.5 to 2 h post-injection CCI-induced CNP mice at day 5 21 versus dimethyl...
In this study, we investigated whether neural precursor cell-expressed developmentally down-regulated gene 4-like (NEDD4L) is the E3 enzyme of angiotensin-converting 2 (ACE2) and NEDD4L degrades ACE2 via ubiquitination, leading to progression pulmonary arterial hypertension (PAH).
Elucidating the genetic, and neuronal bases for learned behavior is a central problem in neuroscience. A leading system neurogenetic discovery vinegar fly Drosophila melanogaster; memory research has identified genes circuits that mediate aversive appetitive learning. However, methods to study adaptive food-seeking this animal have lagged decades behind rodent feeding analysis, largely due challenges presented by their small scale. There currently no method dynamically control flies' access...
Neuropathic pain (NP) is often accompanied by psychiatric comorbidities and currently lacks effective treatment. Prior research has shown that HDAC6 plays a crucial role in sensitization, but the specific mechanisms remain unclear. inhibitors have been found to alleviate mechanical allodynia caused inflammation peripheral nerve damage. In this study, we investigated cellular of development maintenance neuropathic pain. Our findings indicate expression spinal cord (SC) upregulated...
Aim: The medial prefrontal context (mPFC) plays pivotal roles in initiation, development, and maintenance of chronic pain, whereas the underlying molecular mechanisms remain elusive, which invited investigation potential involvement MKP1 mPFC mice neuropathic its cellular mechanisms.Materials methods: Neuropathic pain model was established adult male Kunming via constrictive injury (CCI) sciatic nerve. Paw withdrawal latency (PWL) measured at plantar area by radiant heat test. Stereotaxic...
Background: Lactic acidosis is often seen in lung transplantation (LTx). Postoperative lactate frequently associated with poor outcome postoperative and critically ill patients. Our aim was to evaluate the predictive value of peak levels within 72 h LTx for 30-day late mortality. Methods: We evaluated patients who underwent from January 2015 September 2017. All admitted were classified according level (PL) surgery: PL <5 mmol/L (Group 1); =5–10 2), >10 3). performed logistic regression...