A5081892432- Salmonella and Campylobacter epidemiology
- Bacterial Identification and Susceptibility Testing
- Viral gastroenteritis research and epidemiology
- Streptococcal Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- Infective Endocarditis Diagnosis and Management
- Bacteriophages and microbial interactions
- Bacterial biofilms and quorum sensing
- Plant and animal studies
- Cystic Fibrosis Research Advances
- Rangeland and Wildlife Management
- Influenza Virus Research Studies
- Botany, Ecology, and Taxonomy Studies
- Veterinary medicine and infectious diseases
- Antibiotic Resistance in Bacteria
- RNA Interference and Gene Delivery
- Cancer Research and Treatments
- Archaeology and Natural History
- Bacterial Genetics and Biotechnology
- Orthopedic Infections and Treatments
- Ecology and Vegetation Dynamics Studies
- Escherichia coli research studies
- Horticultural and Viticultural Research
Henry M. Jackson Foundation
2019-2023
Naval Medical Research Command
2019-2023
Jackson Foundation
2023
Auburn University
2014-2022
The Ohio State University
2018-2020
Interface (United States)
2020
National Park Service
2017
University of North Carolina at Asheville
2017
Walker (United States)
2015
Pseudomonas aeruginosa causes devastating infections in immunocompromised individuals. Once established, P. become incredibly difficult to treat due the development of antibiotic tolerant, aggregated communities known as biofilms. A hyper-biofilm forming clinical variant aeruginosa, a rugose small-colony (RSCV), is frequently isolated from chronic and correlated with poor outcome. The these mutants during infection suggests selective advantage for this phenotype, but it remains unclear how...
Pseudomonas aeruginosa colonizes the airways of cystic fibrosis (CF) patients, causing infections that can last for decades. During course these infections, P. undergoes a number genetic adaptations. One such adaptation is loss swimming motility functions. Another involves formation rugose small colony variant (RSCV) phenotype, which characterized by overproduction exopolysaccharides Pel and Psl. Here, we provide evidence two adaptations are linked. Using random transposon mutagenesis,...
Molecular imaging by definition is the visualization of molecular and cellular processes within a given system. The modalities reagents described here represent diverse array spanning both pre-clinical clinical applications. Innovations in probe design technologies would greatly benefit therapeutic outcomes enhancing diagnostic accuracy assessment acute therapy. Opportunistic pathogens continue to pose worldwide threat, despite advancements treatment strategies, which highlights continued...
Campylobacter jejuni is a leading cause of diarrheal disease worldwide, and currently no preventative interventions are available. C. an invasive mucosal pathogen that has variety polysaccharide structures on its surface, including capsule. In phase 1 studies, capsule conjugate vaccine was safe but poorly immunogenic when delivered alone or with aluminum hydroxide. Here, we report enhanced immunogenicity the liposome adjuvants containing monophosphoryl lipid A without QS-21, known as ALF...
In several regions of the world, species richness lianas (woody vines) has been shown to decrease as elevation increases. Little is known about relationship between and in temperate forests eastern North America. We documented elevational distribution 4 high-climbing, native Pisgah National Forest (western Carolina) by recording elevations 427 vine occurrences along 53 km trails. All taxa occurred at lowest elevations. Mean Toxicodendron radicans (Poison Ivy; 873 ± 71 m) Parthenocissus...
Streptococcus pyogenes ( S. ) can thrive in its host during an infection, and, as a result, it must be able to respond external stimuli and available carbon sources. The preclinical use of engineered pathogens capable constitutive light production may provide realtime information on microbial-specific metabolic processes. Here we mapped the central metabolism luxABCDE -modified Xen20 Strep . Xen20) de novo synthesis luciferase substrates assessed by rate response different environmental...
Streptococcus pyogenes (S. pyogenes) can thrive in its host during an infection, and, as a result, it must be able to respond external stimuli and available carbon sources. The preclinical use of engineered pathogens capable constitutive light production may provide real-time information on microbial-specific metabolic processes. In this study, we mapped the central metabolism luxABCDE-modified S. Xen20 (Strep. Xen20) de novo synthesis luciferase substrates assessed by rate response...
Abstract We set out to develop and characterize a small animal model of Campylobacter jejuni(CJ) infection that recapitulates human campylobacteriosis. Adult C57BL/6J mice are rendered susceptible colonization disease by pre-treatment with zinc deficient diet broad-spectrum antibiotic cocktail. have established this four strains diverse capsular serotypes flagellar groups, two key virulence factors for CJ pathogenesis. measured colonization, weight loss, diarrhea, fecal inflammatory markers,...
ABSTRACT The National Natural Landmarks Program recognizes and encourages the conservation of sites that contain outstanding biological geological resources. Sites are designated by Secretary Interior for their condition, illustrative character, rarity, diversity, value to science education. Park Service administers program works cooperatively with landowners, managers partners promote appreciation nation's natural heritage. There currently 599 nationwide; nearly 60% determined be...
Abstract Campylobacter jejuni is a major cause of infectious diarrhea worldwide. Increasing incidence C. attributed to new non-culture based detection methods and antibiotic resistance unfortunately on the rise, necessitating development interventions. Therapeutics like vaccines have been hampered by lack small animal model that recapitulates campylobacteriosis symptoms. To better facilitate vaccine efficacy testing, we adapted recently-published mouse infection adult mice fed zinc-deficient...