A5052368006- Thallium and Germanium Studies
- Chemical Synthesis and Analysis
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Analytical chemistry methods development
- Asymmetric Hydrogenation and Catalysis
- Orthopaedic implants and arthroplasty
- Synthetic Organic Chemistry Methods
- Asymmetric Synthesis and Catalysis
- Catalytic C–H Functionalization Methods
- Selenium in Biological Systems
- Cyclopropane Reaction Mechanisms
- Radioactive element chemistry and processing
- Catalytic Cross-Coupling Reactions
- Chemical synthesis and alkaloids
- Diamond and Carbon-based Materials Research
- Organoboron and organosilicon chemistry
- Inorganic Chemistry and Materials
- Heavy metals in environment
- Crystallography and molecular interactions
- Coordination Chemistry and Organometallics
- Infrared Target Detection Methodologies
- Inorganic and Organometallic Chemistry
- Marine Sponges and Natural Products
- Geochemistry and Elemental Analysis
Guangzhou University
2019-2025
University of Padua
2021-2023
Harbin University of Science and Technology
2021-2022
Hebei University of Technology
2022
Boehringer Ingelheim (United States)
2009-2021
Shanghai Institute of Technology
2019-2021
Shanghai Institute of Microsystem and Information Technology
2015-2016
State Key Laboratory of Transducer Technology
2015-2016
Chinese Academy of Sciences
2012-2015
Boehringer Ingelheim (Germany)
2010-2014
Biaryl monophosphorus ligands containing a 2,3-dihydrobenzo[d][1,3]oxaphosphole framework are highly effective for the palladium-catalyzed Suzuki–Miyaura cross-coupling reactions of wide range substrates. Ligand 1 has demonstrated excellent performance coupling extremely hindered arylboronic acids. Detailed facts importance to specialist readers published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted by authors....
A series of novel P-chiral monophosphorus ligands exhibit efficiency in asymmetric Suzuki–Miyaura coupling reactions, enabling the construction an array chiral biaryl products high yields and excellent enantioselectivities (up to 96% ee) under mild conditions. The carbonyl-benzooxazolidinone moiety these allows facile derivatization for further synthetic applications. computational study has revealed that a π–π interaction between two partners can enhance enantioselectivity reaction.
A series of novel, efficient, air-stable, and tunable chiral bisdihydrobenzooxaphosphole ligands (BIBOPs) were developed for rhodium-catalyzed hydrogenations various functionalized olefins such as α-arylenamides, α-(acylamino)acrylic acid derivatives, β-(acylamino)acrylates, dimethyl itaconate with excellent enantioselectivities (up to 99% ee) reactivities 2000 TON).
In combination with the Bedford Pd precursor, new biaryl monophosphorus ligand 5 was efficient for palladium-catalyzed Miyaura borylation of sterically hindered aryl bromides at low catalyst loadings.
The ring-closing metathesis (RCM) step, a key reaction in our process to BILN 2061, was dramatically improved from the first-generation by selection of more appropriate substrate as well use effective catalyst. two RCM reactions are compared detail using criteria that high significance chemist.
A series of structurally novel, operationally convenient, and efficient chiral 2-phosphino-2,3-dihydrobenzo[d][1,3]oxaphosphole ligands was developed. Applications 3a 3b in rhodium-catalyzed asymmetric hydrogenation alpha-(acylamino)acrylates beta-(acylamino)acrylates provided excellent enantioselectivities (up to >99% ee) reactivities 10,000 TON).
A general, scalable, and highly diastereoselective aziridination of N-tert-butanesulfinyl ketimino esters is described. The methodology has been utilized to provide straightforward access previously unobtainable, biologically relevant α-quaternary amino derivatives starting from readily available precursors.
An Ir-catalyzed enantioselective hydrogenation of 2-alkyl-pyridines has been developed using ligand MeO-BoQPhos. High levels enantioselectivities up to 93:7 er were obtained. The resulting enantioenriched piperidines can be readily converted into biologically interesting molecules such as the fused tricyclic structures 5, 6, and 7 in 99:1 er, providing a novel, concise synthetic route this family chiral piperidine-containing compounds.
A concise asymmetric synthesis of an 11β-HSD-1 inhibitor has been achieved using inexpensive starting materials with excellent step-economy at low catalyst loadings. The catalytic enantioselective total 1 was accomplished in 7 steps and 38% overall yield aided by the development innovative, sequential strategy involving Pd-catalyzed pyridinium C-H arylation Ir-catalyzed hydrogenation resulting fused tricyclic indenopyridinium salt highlighted use a unique P,N-ligand (MeO-BoQPhos) 1000 ppm...
Boron trifluoride-etherate promotes the endo-selective oxacyclization of polyepoxides derived from various acyclic terpenoid polyalkenes, including geraniol, farnesol, and geranylgeraniol, providing an efficient stereoselective synthesis substituted oxepanes fused polyoxepanes. The mechanism reaction probably involves intramolecular nucleophilic addition epoxide oxygen to open another that is activated as electrophile by Lewis acid. These oxacyclizations proceed stereospecifically with...
Biaryl-Monophosphorliganden mit einem 2,3-Dihydrobenzo[d][1,3]oxaphosphol-Gerüst ergeben hoch effiziente palladiumkatalysierte Suzuki-Miyaura-Kreuzkupplungen verschiedenartigen Substraten. Der Ligand 1 eignet sich außerordentlich gut für Kupplungen von sterisch stark gehinderten Arylboronsäuren.