A5101987764- Enzyme Catalysis and Immobilization
- Click Chemistry and Applications
- Retinoids in leukemia and cellular processes
- Forest, Soil, and Plant Ecology in China
- GABA and Rice Research
- Evolution and Genetic Dynamics
- Estrogen and related hormone effects
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Gene expression and cancer classification
- Ecology and Conservation Studies
- Microbial Metabolic Engineering and Bioproduction
- Amino Acid Enzymes and Metabolism
- Chromosomal and Genetic Variations
Zhangzhou Normal University
2023
Institute of Hydrobiology
2020
Chinese Academy of Sciences
2020
Xiamen University
2014
Sanford Burnham Prebys Medical Discovery Institute
2014
Retinoid X receptor-alpha (RXRα) is implicated in the regulation of many biological processes and also represents a unique intracellular target for pharmacologic interventions. Efforts on discovery small molecules targeting RXRα have been primarily focused that bind to its classical ligand-binding pocket (LBP). Here, we report identification characterization new transcriptional antagonist by using structure-based virtual screening. The binds with submicromolar affinity (Kd = 4.88 × 10-7 M)...