A5044547805- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Vaccine Coverage and Hesitancy
- Health Systems, Economic Evaluations, Quality of Life
- Respiratory and Cough-Related Research
- Chronic Disease Management Strategies
- Eosinophilic Esophagitis
- Viral Infections and Outbreaks Research
- Primary Care and Health Outcomes
- Data-Driven Disease Surveillance
- COVID-19 Clinical Research Studies
- Lipoproteins and Cardiovascular Health
- Allergic Rhinitis and Sensitization
- Inhalation and Respiratory Drug Delivery
- Disaster Response and Management
- Maternal and Perinatal Health Interventions
- Global Health Workforce Issues
- Medical Education and Admissions
- Ecology, Conservation, and Geographical Studies
- Bacterial Infections and Vaccines
- Transgenic Plants and Applications
- Poxvirus research and outbreaks
- Dermatology and Skin Diseases
- Educational Assessment and Improvement
Imperial College London
2019-2025
AstraZeneca (United Kingdom)
2022-2025
The London College
2025
Focus (Germany)
2021
Heel (Germany)
2004
Background Pivotal phase 3 trials and real-world studies have demonstrated benralizumab's overall efficacy safety in severe eosinophilic asthma (SEA). Additional large-cohort data are needed to confirm its effectiveness SEA according previous biologic use key baseline characteristics important for treatment selection. Methods XALOC-1 is a large, multinational, retrospective, observational, study programme of benralizumab adults with SEA. This 48-week integrated analysis assessed annualised...
Abstract: In 2022, over 3 million people died of chronic obstructive pulmonary disease (COPD) and the global burden is expected to increase coming decades. Recommendations for treatment management patients with COPD are published by Global Initiative Chronic Obstructive Lung Disease, updated annually scientific evidence-based recommendations. The 2023 updates, in November contain key changes recommendations diagnosis that anticipated have a significant impact on clinical practice COPD....
Purpose: There has been concern that asthma and chronic obstructive pulmonary disease [COPD] increase the risk of developing exacerbating COVID-19. The effect medications such as inhaled corticosteroids (ICS) biologics on COVID-19 is unclear. This systematic literature review analyzed published evidence epidemiology burden illness COPD, use baseline medicines among populations. Patients Methods: Using Preferred Reporting Items for Systematic Reviews Meta-Analyses guidelines, Embase®,...
Guidelines for the management of dyslipidemias recommend intensive low-density lipoprotein (LDL-C) control through lifestyle advice and lipid-lowering drugs to reduce risk cardiovascular disease (CVD).This retrospective study aimed characterize adult primary care population with hypercholesterolemia (PH)/mixed dyslipidemia (MD).Data on adults PH/MD between 1 January 2009 31 December 2019 in UK were extracted from linked Clinical Practice Research Datalink (CPRD) secondary (Hospital Episode...
Plain Language SummaryWhat is this summary about?This a of an article originally published in the European Respiratory Journal, which presented combined results from five retrospective real-world studies (i.e., looking at data collected during historical medical appointments) that each took place different country and which, together, formed XALOC-1 study programme. looked how effective benralizumab injections were clinical practice treating type asthma called 'severe eosinophilic...
Purpose: Extracting and structuring relevant clinical information from electronic health records (EHRs) remains a challenge due to the heterogeneity of systems, documents, documentation practices. Large Language Models (LLMs) provide an approach processing semi-structured unstructured EHR data, enabling classification, extraction, standardization. Methods: Medical documents are processed through structured data pipeline generate normalized FHIR data. Unstructured undergoes preprocessing,...
<ns4:p>This article was migrated. The marked as recommended. COVID-19 and the resulting lockdown policies have far ranging effects on health professions education (HPEd), with an impact in all its aspects, including curricula, teaching methods, student selection processes, educational outcomes, HPEd research, student, teacher, school welfare. Adaptations to pandemic measures leaned heavily technology. may differences across various particularly those emphasis psychomotor skills. There also...
Background: The complex nature of asthma has resulted in a poor understanding its epidemiology, particularly low-and middle-income countries (LMIC). Clinical subgroups, such as patients with severe asthma, eosinophilic allergic rhinitis, or nasal polyps, experience additional barriers to care. Methods: Prevalence estimates for and key clinical subgroups were extracted from the Global Burden Diseases, Injuries, Risk Factors Study 2019 targeted literature review conducted through PubMed...
Cost-utility analyses for acute myeloid leukemia (AML) require health state utility values (HSUVs) in order to calculate quality-adjusted life-years (QALYs) each state.This study reviewed AML-related HSUVs that could be used economic evaluation studies.EMBASE, MEDLINE, and Cochrane databases were searched from January 2000 November 2016 relevant studies reported quality of life (QoL) AML. Identified European Organization Research Treatment Cancer Quality Life Questionnaire Core 30 mapped...
Background Hospitalised pneumonia may have long-term clinical and financial impact in adult patients with underlying comorbidities. Methods We conducted a retrospective cohort study using the Hospital Episode Statistics (HES) database to determine burden over 3 years of hospitalised community-acquired (CAP) England’s National Health Service (NHS). Subjects were adults six comorbidities (chronic heart disease (CHD); chronic kidney (CKD); liver (CLD); respiratory (CRD); diabetes mellitus (DM)...
Treatments for mild viral infections are usually directed at providing symptomatic relief. The effectiveness of the homoeopathic remedy Gripp-Heel® was compared with that conventional treatments in a prospective, observational cohort study 485 patients and symptoms such as fever, headache, muscle pain, cough or sore throat. Practitioners specialised homoeopathy treatment, practised both to similar extents. As evaluated by practitioners, therapy effective greater degree than therapies: 67.9%...
Policy Points The 2018 Declaration of Astana reemphasized the importance primary health care and its role in achieving universal coverage. While there is a large amount literature on economic aspects delivering services, need for more comprehensive overviews this evidence. In article, we offer such an overview. Evidence suggests that are several strategies involving coverage, financing, service delivery, governance arrangements which can, if implemented, have positive impacts delivery...
Introduction Effective treatment of severe asthma requires patient adherence to inhaled and biological medications. Previous work has shown that support programmes (PSP) can improve in patients with chronic diseases, but the impact PSPs treated biologics not been thoroughly investigated. Methods We conducted a systematic literature review understand on adherence, control health-related quality life (HRQoL) asthma. Embase, MEDLINE EconLit databases were searched for studies published from...
Abstract In 2004, the South African Education and Labour Relations Council announced that an agreement had been reached to integrate several existing programmes on quality management in education into a new programme entitled Integrated Quality Management System (IQMS) for School-based educators. order help educators particular Province of Africa cope with demands this programme, Advanced Certificate was instituted. The first cohort teacher-students taking ACE subsequently subjected...
Is the inner city an attractive place for “young elderly” to live? During decades suburbanization was dominant pattern of development in Germany. However, since 2000s increasing attraction urban living and trend re-urbanization are discussed research as well public. Due average age life expectancy population a main sub-process demographic change Germany, question arises whether residential area also becomes more elderly. Especially people (ca. 50–70 years old) getting into focus. Because...
Objectives Determine the prevaccination healthcare impact of COVID-19 in patients with systemic lupus erythematosus (SLE) England. Design Retrospective cohort study adult SLE from 1 May to 31 October 2020. Setting Clinical Practice Research Datalink (CPRD) Aurum and Hospital Episode Statistics (HES) databases general practitioners across England combining primary care other health-related data. Participants Overall, 6145 adults confirmed diagnosis ≥1 year prior 2020 were included. Most women...