A5039578846- Lipoproteins and Cardiovascular Health
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical Economics and Policy
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Migraine and Headache Studies
- Mechanisms of cancer metastasis
- Retinal Development and Disorders
- Cancer-related Molecular Pathways
- Atrial Fibrillation Management and Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Ischemic Stroke Management
- Psychosomatic Disorders and Their Treatments
- Health Promotion and Cardiovascular Prevention
- Cancer Mechanisms and Therapy
- Trigeminal Neuralgia and Treatments
- Acute Myeloid Leukemia Research
- Zebrafish Biomedical Research Applications
- Cardiac, Anesthesia and Surgical Outcomes
- Kruppel-like factors research
- Ocular Oncology and Treatments
- Acute Lymphoblastic Leukemia research
- Parkinson's Disease Mechanisms and Treatments
- Renal and related cancers
- Synthesis and biological activity
- Global Health Care Issues
Daiichi Sankyo (Germany)
2020-2023
Bayer (Germany)
2022
Daiichi-Sankyo (South Korea)
2022
Daiichi-Sankyo (Japan)
2021
Novartis (Ireland)
2018
Space Hellas (Greece)
2015-2016
Pfizer (United States)
2015
University College London
2010-2012
University College Hospital
2012
Hutchison/MRC Research Centre
2009
European data pre-2019 suggest statin monotherapy is the most common approach to lipid management for preventing cardiovascular (CV) events, resulting in only one-fifth of high- and very high-risk patients achieving 2019 ESC/EAS recommended low-density lipoprotein cholesterol (LDL-C) goals. Whether treatment landscape has evolved, or gaps persist remains interest.Baseline are presented from SANTORINI, an observational, prospective study that documents use lipid-lowering therapies (LLTs) ≥18...
Migraine is a distinct neurological disease that imposes significant burden on patients, society, and the healthcare system. This study aimed to characterize incremental of migraine in individuals who suffer from ≥4 monthly headache days (MHDs) by examining health-related quality life (HRQoL), impairments work productivity daily activities, resource utilization (HRU) EU5 (France, Germany, Italy, Spain, United Kingdom).This retrospective cross-sectional used data 2016 National Health Wellness...
Migraine is a neurological disease characterized by recurring attacks that can cause severe disabling pain. This study described the burden of migraine as reported individuals with in real world using mobile application.A retrospective, cross-sectional analysis was conducted data captured through Buddy© smartphone application from adult, self-diagnosed 17 European countries. Data were analyzed descriptively for most recent 28-day period users (n = 3900) during (June 2015-July 2016) who...
Guidelines for the management of dyslipidemias recommend intensive low-density lipoprotein (LDL-C) control through lifestyle advice and lipid-lowering drugs to reduce risk cardiovascular disease (CVD).This retrospective study aimed characterize adult primary care population with hypercholesterolemia (PH)/mixed dyslipidemia (MD).Data on adults PH/MD between 1 January 2009 31 December 2019 in UK were extracted from linked Clinical Practice Research Datalink (CPRD) secondary (Hospital Episode...
Clinical practice before 2019 suggests a substantial proportion of high and very CV risk patients taking lipid-lowering therapy (LLT) would not achieve the new LDL-C goals recommended in ESC/EAS guidelines (<70 < 55 mg/dL, respectively). To what extent has changed since last guideline update is uncertain, quantification remaining implementation gaps may inform health policy.The SANTORINI study multinational, multicentre, prospective, observational, non-interventional documenting patient data...
Abstract Background In Xenopus retinogenesis, p27Xic1, a cyclin dependent kinase inhibitor, functions as cell fate determinant in both gliogenesis and neurogenesis context manner. This activity is essential for co-ordination of determination cycle regulation. However, very little known about the mechanism regulating choice between versus neurogenesis. Results We have identified NM23-X4, NM23 family member, binding partner p27Xic1. NM23-X4 expressed at periphery ciliary marginal zone retina...
Extraembryonic ectoderm differentiation and chorioallantoic attachment are fibroblast growth factor (FGF)- transforming β-regulated processes that the first steps in development of placenta labyrinth establishment fetal-maternal circulation developing embryo. Only a small number genes have been demonstrated to be important trophoblast stem cell differentiation. Erf is ubiquitously expressed Erk-regulated, ets domain transcriptional repressor throughout embryonic adulthood. However, placenta,...
Patients with atherosclerotic cardiovascular disease who require additional low-density lipoprotein cholesterol (LDL-C) lowering despite maximally tolerated statins have a significant unmet medical need and are at increased risk of future events reduced quality life. We aimed to estimate the percentage avoided following treatment fixed-dose combination bempedoic acid plus ezetimibe (BA+EZE FDC) versus (EZE) in patients receiving across range baseline LDL-C levels. A Markov cohort simulation...
The low-density lipoprotein cholesterol goals in the 2019 European Society of Cardiology/European Atherosclerosis dyslipidaemia guidelines necessitate greater use combination therapies. We describe a real-world cohort patients Austria and simulate addition oral bempedoic acid ezetimibe to estimate proportion reaching goals.Patients at high or very cardiovascular risk on lipid-lowering treatments (excluding proprotein convertase subtilisin/kexin type 9 inhibitors) from Austrian observational...
Background and aims The LDL cholesterol (LDL-C) treatment goals recommended by the 2019 ESC/EAS guidelines are only achieved in a minority of patients. study objective was to estimate impact bempedoic acid on LDL-C target attainment, drug costs, atherosclerotic cardiovascular disease (ASCVD) events. simulation used Monte Carlo approach representative cohort German outpatients at high or very-high risk. Additionally statins, consecutive with ezetimibe, acid, PCSK9 inhibitor simulated patients...
Abstract Background The ESC/EAS 2019 guidelines recommend ambitious lower goals for low-density lipoprotein cholesterol (LDL-C), especially patients with high and very cardiovascular (CV) risk which could necessitate more intensive lipid-lowering therapy (LLT) regimens. Multiple real-world studies in Europe have demonstrated suboptimal achievement of older 2016 LDL-C goals, combination ezetimibe or proprotein convertase subtilisin kexin 9 inhibitors (PCSK9i) used 9% 1% patients,...
The aim of the study was to evaluate cost-effectiveness (CE) treatment with eplerenone versus standard care in adult patients New York Heart Association class II chronic heart failure and reduced left ventricular ejection fraction from perspective Greek national health payer.A discrete-event model simulating clinical course respective outcomes as an add-on therapy alone based on pivotal Eplerenone Mild Patients Hospitalization SurvIval Study Failure (EMPHASIS-HF) trial locally adapted for...
To describe treatment patterns, low-density lipoprotein cholesterol (LDL-C) levels and healthcare resource utilization (HCRU) in the Netherlands 2018 of patients with hypercholesterolaemia or mixed dyslipidaemia at high very cardiovascular (CV) risk.From PHARMO Database Network adult a diagnosis receiving lipid lowering therapy (LLT) between 2009 were selected. Patients CV risk according to 2016 ESC/EAS guidelines recorded LDL-C who treated LLT characterized as statin intolerant included....
e20014 Background: Since 2011, two therapies that provide novel approaches to the treatment of advanced (unresectable or metastatic) melanoma have been introduced market: ipilimumab for second line and vemurafenib BRAF mutation-positive melanoma. It is not known how new drugs influence treatment; this study investigated current patterns in Methods: A clinician-validated, web-based survey was administered between August November 2012 clinicians who treat France, Germany, Italy, Spain, UK....
<b>Objectives:</b> To estimate varenicline9s annual budget impact for Greek Social Security Fund. <b>Methods:</b> A 1y model was locally adapted the Healthcare system from a third-party payer perspective cohort of smokers willing to quit (28% 3.780.000). Smoking cessation strategies consisted behavioural, NRTs, varenicline, bupropion and unaid. Market shares drug treatments were based on IMS sales data expert opinion; 1% market share varenicline used when reimbursed (2008-10). Costs include...