A5014666190- Cellular Mechanics and Interactions
- Axon Guidance and Neuronal Signaling
- Housing, Finance, and Neoliberalism
- Urban and Rural Development Challenges
- Connective tissue disorders research
- Hippo pathway signaling and YAP/TAZ
- Erythrocyte Function and Pathophysiology
- Aortic Disease and Treatment Approaches
- Cardiovascular Health and Disease Prevention
- Renal Diseases and Glomerulopathies
- Housing Market and Economics
- Aortic aneurysm repair treatments
- Renal and Vascular Pathologies
- Muscle Physiology and Disorders
- Reservoir Engineering and Simulation Methods
- Caveolin-1 and cellular processes
- Metal Forming Simulation Techniques
- Sodium Intake and Health
- Chronic Lymphocytic Leukemia Research
- Microtubule and mitosis dynamics
- 3D Printing in Biomedical Research
- Blood Pressure and Hypertension Studies
- Urban, Neighborhood, and Segregation Studies
- Chronic Myeloid Leukemia Treatments
- Hydrology and Watershed Management Studies
Icahn School of Medicine at Mount Sinai
2016-2025
RELX Group (United States)
2019
University of California, Davis
2013
Emerging evidence of crosstalk between glomerular cells in pathological settings provides opportunities for novel therapeutic discovery. Here we investigated underlying mechanisms early events leading to filtration barrier defects podocyte and endothelial cell the mouse models primary podocytopathy (podocyte specific transforming growth factor-β receptor 1 signaling activation) or Adriamycin nephropathy. We found that surface layer degradation albuminuria preceded foot process effacement....
Increased aortic stiffness is a fundamental manifestation of hypertension. However, the molecular mechanisms involved remain largely unknown. We tested hypothesis that abnormal intrinsic vascular smooth muscle cell (VSMC) mechanical properties in large arteries, but not distal contribute to pathogenesis stiffening hypertension, mediated by serum response factor (SRF)/myocardin signalling pathway.Four month old male spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY)...
Glioblastoma (GBM) is a malignant brain tumor with diffuse infiltration. Here, we demonstrate how GBM cells usurp guidance receptor Plexin-B2 for confined migration through restricted space. Using live-cell imaging to track negotiating microchannels, reveal endocytic vesicle accumulation at cell front and filamentous actin assembly rear in polarized manner. These processes are interconnected require signaling. We further show that governs membrane tension other features such as endocytosis,...
Abstract During morphogenesis, molecular mechanisms that orchestrate biomechanical dynamics across cells remain unclear. Here, we show a role of guidance receptor Plexin-B2 in organizing actomyosin network and adhesion complexes during multicellular development human embryonic stem neuroprogenitor cells. manipulations affect contractility, leading to changes cell stiffness cytoskeletal tension, as well cell-cell cell-matrix adhesion. We have delineated the functional domains Plexin-B2,...
ABSTRACT Glioblastoma (GBM) is a malignant brain tumor with uncontrolled invasive growth. Here, we demonstrate how GBM cells usurp guidance receptor Plexin-B2 to gain biomechanical plasticity for polarized migration through confined space. Using live-cell imaging track negotiating microchannels, reveal active endocytosis at cell front and filamentous actin assembly rear propel constrictions. These two processes are interconnected governed by that orchestrates cortical membrane tension, shown...
Preface - Robert J Wiener and Joseph N Belden PART ONE: CONDITIONS AND CONTEXT The Context of Affordable Housing in Rural America Conditions Trends Cushing Dolbeare TWO: PEOPLE PLACES the South Jacquelyn McCray Border Colonias Zixta Martinez,Charles Kamasaki Surabhi Dabir A Framework for Change Midwest Janet Krofta, Sue Crull Christine Cook Hidden Homeless Mary Stover Many Harvests Shame Susan Peck Farmworkers Elderly THREE: PUBLIC PRIVATE MONEY Role Federal Programs Art Collings Privatizing...
Aortic stiffening is strongly associated with both aging and hypertension, but the underlying mechanisms remain unclear. We hypothesized that aging-induced aortic stiffness mediated by a mechanism differing from hypertension.We conducted comprehensive in vivo vitro experiments using multiple rat models to dissect different of hypertension.A time-course study spontaneously hypertensive rats (SHR) Wistar-Kyoto (WKY) normotensive showed more pronounced aging-associated SHR versus WKY....
Effective stem cell therapies and disease modeling depend on understanding epigenetic factors of aging. Accurately age-dependent phenotypes such as aortic, smooth muscle stiffening, requires models that reflect donor age. Improved knowledge how aging influences cell-derived cells is essential for precise creating targeted therapeutics. We hypothesize traits vascular are retained in human induced pluripotent (iPSCs) manifest differentiated (SMCs). aim to compare iPSC stiffness gene expression...
Intervertebral disc (IVD) defects heal poorly and can cause back pain disability. We identified that IVD herniation injury heals regeneratively in neonatal mice until postnatal day 14 (p14) shifts to fibrotic healing by p28. This age coincides with the shift expansive growth from cell proliferation matrix elaboration, implicating collagen crosslinking.
Abstract Marfan Syndrome (MFS), a connective tissue disorder caused by mutation in the fibrillin-1 gene, occurs approximately 1 5,000 people worldwide. As an important constituent of extracellular matrix, mutated leads to aortic medial degeneration, aneurysm, and dissection. TGFβ which is controlled fibrillin-1, known cause pathological effects smooth muscle cells (SMCs) within wall during MFS. as well other cytokines have been shown impact neural crest derived SMCs differently than...
Abstract Glioblastoma is a malignant brain tumor of uncontrolled proliferation and infiltration. GBM stem cells (GSCs) are constantly challenged by confined spaces during their migration through the parenchyma. Understanding factors that drive GSC (CM) thus critical for effective drug development. Using microchannel devices, we showed GSCs adept at squeezing narrow constrictions faster speed than non-constricted spaces. During CM, cytoskeletal components plasma membrane self-organize to...
Across California, and many other parts of the U.S., cities counties all sizes –
 urban, suburban, rural – are responding to severe shortages affordable housing via
 adoption inclusionary (IH) programs. Also known as zoning, IH
 programs encompass a large variety policies that share common element requiring or
 encouraging private developers directly build or facilitate building affordable
 for purchase rent in new single-family home subdivisions apartment...
SUMMARY During multicellular organization, individual cells need to constantly respond environmental cues and adjust contractile adhesive forces in order maintain tissue integrity. The signaling pathways linking biochemical mechanics are unclear. Here, we show that Plexin-B2 regulates mechanochemical integration during organization. In human embryonic stem (hESCs), controls cell shape geometry both 2D epithelial colony 3D spheroid aggregates by regulating actomyosin contractility...
The time of “easy oil and gas from conventional plays” has passed. In recent decades, the industry shifted its focus to unconventional hydrocarbon resources that now make up about two-thirds world’s reserves. well-known types are
La vivienda inclusiva es una practica que encarga a los patrocinadores de viviendas la responsabilidad asegurar un cierto porcentaje las nuevas sean para personas y familias bajos ingresos. Aunque sea controversial, estrategia cada vez mas comun enfrentar escasez bajo costo. Debido esta practica, se han creado 34.000 casas departamentos en California. Hasta marzo 2003, identificado 107 municipios California utilizan (en comparacion con 64 el 1994); consiste 20% del estado. Otros 12 estan...