A5068547899- Management of metastatic bone disease
- Advanced Radiotherapy Techniques
- Brain Metastases and Treatment
- Cancer Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Cancer Cells and Metastasis
- Ultrasound and Hyperthermia Applications
- Glioma Diagnosis and Treatment
- Lung Cancer Research Studies
- Radiomics and Machine Learning in Medical Imaging
- Breast Implant and Reconstruction
- Breast Lesions and Carcinomas
- Spine and Intervertebral Disc Pathology
- Microbial Inactivation Methods
- Multiple and Secondary Primary Cancers
- Cancer survivorship and care
- Infrared Thermography in Medicine
- Lung Cancer Diagnosis and Treatment
- Head and Neck Cancer Studies
- Cardiac pacing and defibrillation studies
- Lung Cancer Treatments and Mutations
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Lymphoma Diagnosis and Treatment
- Medical Imaging Techniques and Applications
Instituut Verbeeten
2006-2021
Utrecht University
2016
University Medical Center Utrecht
2016
Cancer Research Institute
2014
Radboud University Nijmegen
1999
Current clinical guidelines for the management of radiotherapy patients having either a pacemaker or implantable cardioverter defibrillator (both CIEDs: Cardiac Implantable Electronic Devices) do not cover modern techniques and take patient's perspective into account. Available data on frequency cause CIED failure during radiation therapy are limited converge. The Dutch Society Radiotherapy Oncology (NVRO) initiated multidisciplinary task group consisting physicists, cardiologists,...
Prognostic factors of ipsilateral breast tumor recurrence (IBTR) may change over time following breast-conserving therapy.The EORTC "boost no boost" trial showed that young age and high-grade invasive carcinoma were the most important risk for IBTR. This study reanalyses pathological prognostic related to IBTR using long-term follow-up.Participants included 5569 early-stage cancer patients, treated with surgery (BCS) whole-breast irradiation (WBI), who randomized between boost a 16-Gy in...
The clinical value of whole brain radiotherapy (WBRT) for metastases (BM) is a matter debate due to the significant side effects involved. Stereotactic radiosurgery (SRS) an attractive alternative treatment option that may avoid these and improve local tumor control. We initiated randomized trial (NCT02353000) investigate whether quality life better preserved after SRS compared with WBRT in patients multiple metastases.Patients 4-10 BM were between standard arm (total dose 20 Gy 5 fractions)...
We previously demonstrated that 48% of patients with pain at sites irradiated bone metastases benefit from reirradiation. It is unknown whether alleviating also improves patient perception quality life (QOL).We used the database a randomized trial comparing radiation treatment dose fractionation schedules to evaluate response, determined using International Consensus Endpoint (ICE) and Brief Pain Inventory score (BPI-PS), associated benefit, as measured European Organisation for Resesarch...
Patients with irresectable locoregional recurrent breast cancer en cuirasse (BCEC) do not have effective curative treatment options. Hyperthermia, the elevation of tumor temperature to 40-45 °C, is a well-established radio- and chemotherapy sensitizer. A total 196 patients were treated reirradiation hyperthermia (reRT+HT) at two Dutch institutes from 1982-2005. The palliative effect was evaluated in terms clinical outcome toxicity.All received previous irradiation median dose 50 Gy. In all,...
Combining reirradiation (reRT) and hyperthermia (HT) has shown high therapeutic value for patients with locoregional recurrent breast cancer (LR). However, additional toxicity of (e.g., rib fractures) may occur. The aim this study is to determine the impact potential risk factors on occurrence fractures.From 1982-2005, 234 were treated adjuvant reRT + HT after surgery LR. ReRT consisted typically 8 fractions 4 Gy twice a week, or 12 3 four times week. A total 118 irradiated abutted photon...
Combining reirradiation (reRT) with hyperthermia (HT) has shown to be of high therapeutic value for patients loco-regionally recurrent breast cancer. The purpose this study was compare the long-term effect and toxicity reRT + HT following surgery cancer using two different regimens. regimen 78 treated in Institute A consisted 8 × 4 Gy twice a week mostly abutted photon-electron fields. B received 12 3 Gy, four times single or multiple electron Superficial applied once B. Both institutes...
________________________________________________________________________________locoregional right-sided breast cancer treatment in this study, a slightly lower risk of pneumonitis and secondary lung (in ever-smoking patients) can be expected.In addition, we estimate that for 10-25% the patients heart dose will also reduced.We therefore suggest to apply breath-hold locoregional irradiation (with without IMN) with cancer.
15543 Background: RI-EC is a rare but well identified disease. Treatment strategy remains uncertain as surgery or reirradiation are often not possible in such second cancers. Methods: was defined tumor with different histology than the primary tumor, occurring previous treatment fields, at least 5 years after irradiation according to Cahan criteria. A case - control study patients matched sex, age and year of diagnosis performed. 74 were included study. We report preliminary results on...
Background: Since publication of the QUARTZ trial, clinical value whole brain radiotherapy (WBRT) for metastases is a matter debate due to significant side effects. In order avoid these effects and improve local tumor control, stereotactic radiosurgery (SRS) an attractive treatment option. We have initiated randomized trial (NCT02353000) investigate whether quality life better preserved after SRS alone than WBRT in patients with newly diagnosed multiple metastases. Methods: Patients 4 up 10...