A5026657935- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Epilepsy research and treatment
- Neural dynamics and brain function
- Mental Health Research Topics
- EEG and Brain-Computer Interfaces
- Child Abuse and Trauma
- Vestibular and auditory disorders
- Transcranial Magnetic Stimulation Studies
- Child Welfare and Adoption
- Dementia and Cognitive Impairment Research
- Optical Imaging and Spectroscopy Techniques
- Neuroscience and Neuropharmacology Research
- MRI in cancer diagnosis
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurological disorders and treatments
- Memory and Neural Mechanisms
- Homelessness and Social Issues
- Neural and Behavioral Psychology Studies
University of Electronic Science and Technology of China
2016-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Renmin University of China
2021
Schizophrenia is characterized by complex psychiatric symptoms and unclear pathological mechanisms. Most previous studies have focused on the morphological changes that occur over development of disease; however, corresponding functional trajectories remain unclear. In present study, we aimed to explore progressive patterns dysfunction after diagnosis.
The purpose of this study was to investigate the local spatiotemporal consistency spontaneous brain activity in patients with frontal lobe epilepsy (FLE). Eyes closed resting-state functional magnetic resonance imaging (fMRI) data were collected from 19 FLE and age- gender-matched healthy controls. A novel measure, named FOur-dimensional (spatiotemporal) Consistency neural Activities (FOCA) used assess (emphasizing both temporal homogeneity regional stability states). Then, two-sample t test...
Abstract The interaction between cerebellum and cerebrum participates widely in function from motor processing to high‐level cognitive affective processing. Because of the symptom, idiopathic generalized epilepsy (IGE) patients with tonic–clonic seizure have been recognized associate abnormalities, but functional cerebello–cerebral circuit is still poorly understood. Resting‐state magnetic resonance imaging data were collected for 101 IGE 106 healthy controls. voxel‐based connectivity (FC)...
Idiopathic generalized epilepsy (IGE) is characterized by cryptogenic etiology and the striatum cerebellum are recognized as modulators of epileptic network. We collected simultaneous electroencephalogram functional magnetic resonance imaging data from 145 patients with IGE, 34 whom recorded interictal discharges (IEDs) during scanning. In states without IEDs, hierarchical connectivity was performed to search core cortical regions which might be potentially modulated cerebellum. Node-node...
Abstract Gradients capture the underlying functional organization of brain. Cortical gradients have been well characterized, however very little is known about gradient white matter. Here, we proposed a functionally mapping corpus callosum by using blood-oxygen-level-dependent magnetic resonance imaging (BOLD-fMRI), which for first time uncovered three distinct but stable spatial axes: posterior-anterior, dorsal-ventral, and left-right. The patterns were replicated in another independent...
Abstract Aims Motor abnormalities have been identified as one common symptom in patients with generalized tonic–clonic seizures (GTCS) inspiring us to explore the disease a motor execution condition, which might provide novel insight into pathomechanism. Methods Resting‐state and motor‐task fMRI data were collected from 50 GTCS, including 18 newly diagnosed without antiepileptic drugs (ND_GTCS) 32 receiving (AEDs_GTCS). activation its association head motion cerebral gradients assessed....
The cerebral functional reorganization and declined cognitive function of aging might associate with altered vascular features. Here, we explored the hierarchical network 2 conditions (task-free naturalistic stimuli) in older adults its relationship features (systemic microvascular perfusion features, measured by magnetic resonance imaging) behavior. Using gradient analysis, found that compressive resting-state mainly located on primary sensory-motor system transmodal regions aging, further...
A resting-state functional connectivity (rsFC)-constructed network (FN) derived from magnetic resonance imaging (fMRI) data can effectively mine alterations in brain function during aging due to the noninvasive and effective advantages of fMRI. With global health research focusing on aging, several open fMRI datasets have been made available that combine deep learning with big are a new, promising trend issue for information detection studies aging. In this study, we proposed new framework...
Background How the functional interactions of basal ganglia/thalamus with cerebral cortex and cerebellum change over adult lifespan in movie‐watching resting‐state is less clear. Purpose To investigate changes organization human cortical–subcortical networks using fMRI data. Study Type Cohort. Subjects Healthy 467 adults (cross‐sectional individuals aged 18–88 years) from Cambridge Centre for Ageing Neuroscience ( www.cam-can.com ). Field Strength/Sequence a gradient‐echo echo‐planar imaging...
The entorhinal cortex (EC) plays an essential role in age-related cognitive decline. However, the effect of functional connectivity (FC) changes between EC and other cerebral cortices on function remains unclear. aim this study was to explore modulation two interventions (cognitive training aerobic exercise) EC-FC community-dwelling older adults. In total, 94 healthy adults aged 65 75 years were assigned either or exercise group receive 24 sessions over 12 weeks, a control group....
Hierarchical functional structure plays a crucial role in brain function. We aimed to investigate how aging affects hierarchical and evaluate the relationship between such effects molecular, microvascular, cognitive features. used resting-state magnetic resonance imaging (fMRI) data from 95 older adults (66.94 ± 7.23 years) 44 younger (21.8 2.53 employed an innovative graph-theory-based analysis (stepwise connectivity (SFC)) reveal of on brain. In group, SFC pattern converged primary...
Despite a large population of registered people with drug addiction, child protection in substance-abusing families is neglected issue China. The present study aims to investigate the association between parents’ childhood abuse history and risk abusing their own children Chinese also examine mediating role detachment moderating social support during intergenerational transmission abuse. A total 173 men 116 women were selected using cluster sampling from two compulsory rehabilitation centers...