Rachel Kast

ORCID: 0000-0001-5258-8748
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About
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Research Areas
  • Spectroscopy Techniques in Biomedical and Chemical Research
  • Spectroscopy and Chemometric Analyses
  • Molecular Biology Techniques and Applications
  • Sepsis Diagnosis and Treatment
  • Respiratory Support and Mechanisms
  • Gold and Silver Nanoparticles Synthesis and Applications
  • Laser-induced spectroscopy and plasma
  • COVID-19 Clinical Research Studies
  • Intensive Care Unit Cognitive Disorders
  • Bone Tissue Engineering Materials
  • Hormonal Regulation and Hypertension
  • Orthopedic Infections and Treatments
  • Clinical Nutrition and Gastroenterology
  • Optical Imaging and Spectroscopy Techniques
  • Poisoning and overdose treatments
  • Orthopaedic implants and arthroplasty
  • Healthcare Policy and Management
  • Patient Satisfaction in Healthcare
  • Neuroblastoma Research and Treatments
  • Microfluidic and Bio-sensing Technologies
  • Polymer Surface Interaction Studies
  • Advanced Chemical Sensor Technologies
  • Long-Term Effects of COVID-19
  • biodegradable polymer synthesis and properties
  • Thermography and Photoacoustic Techniques

HealthPoint Communications
2022

Ewha Womans University
2021

University of Ottawa
2021

Seoul National University
2021

Healthpoint
2021

Wayne State University
2008-2020

Trinity Health
2018

Abstract Raman spectroscopy shows potential in differentiating tumors from normal tissue. We used with near‐infrared light excitation to study breast tissue and 11 mice injected a cancer cell line. Spectra were collected 17 tumors, 18 samples of adjacent lymph nodes, the contralateral its nodes. Discriminant function analysis was for classification principal component scores as input data. Tissues examined by microscopy following formalin fixation hematoxylin eosin staining. histology agreed...

10.1002/bip.20899 article EN Biopolymers 2007-11-26

<b><i>Purpose:</i></b> Raman spectroscopy can quickly and accurately diagnose tissue in near real-time. This study evaluated the capacity of to pediatric brain tumors. <b><i>Experimental Design:</i></b> Samples untreated medulloblastoma (4 samples 4 patients), glioma (i.e. astrocytoma, oligodendroglioma, ependymoma, ganglioglioma other gliomas; 27 19 normal (33 5 patients) were collected fresh from operating room or our frozen tumor bank....

10.1159/000343285 article EN Pediatric Neurosurgery 2012-01-01

Few studies have been reported that focus on developing implant surface nanofiber (NF) coating to prevent infection and enhance osseointegration by local drug release. In this study, coaxial doxycycline (Doxy)-doped polycaprolactone/polyvinyl alcohol (PCL/PVA) NFs were directly deposited a titanium (Ti) during electrospinning. The interaction of loaded Doxy with both PVA PCL was characterized Raman spectroscopy. bonding strength Doxy-doped NF Ti implants confirmed stand single-pass scratch...

10.1088/1748-605x/aa6a26 article EN Biomedical Materials 2017-03-30

Objectives The acute respiratory distress syndrome (ARDS) is a heterogeneous condition, and identification of subphenotypes may help in better risk stratification. Our study objective to identify ARDS using new simpler methodology readily available clinical variables. Setting This retrospective Cohort Study trials. Data from the US ARDSNet trials international ART trial. Participants 3763 patients data sets 1010 set. Primary secondary outcome measures primary was 60-day or 28-day mortality,...

10.1136/bmjopen-2021-053297 article EN cc-by-nc BMJ Open 2022-01-01

Objectives: Detection of neoplastic changes using optical spectroscopy has been an active area research in recent times. Raman is a vibrational spectroscopic technique that can be used to diagnose various tumors with high sensitivity and specificity. We evaluated the ability differentiate normal pancreatic tissue from malignant mouse model. Methods: collected 920 spectra, 475 31 445 29 tumor nodules 785-nm near-infrared laser excitation. Discriminant function analysis was for classification...

10.1097/mpa.0b013e31815a3f1c article EN Pancreas 2008-03-01

Amorphous calcium polyphosphate ( ACPP ), an inorganic polymer ceramic, has shown promise as a drug delivery matrix following repeat gelling protocol. This study described simple method of preparing hydrogel in the presence excess volume water. The increased water availability accelerates molecule ingress and microstructural transformation hydrogels. impact some experimental settings (soaking time, temperature, stirring, particle size) on physiochemical rheological natures were investigated...

10.1111/jace.13785 article EN Journal of the American Ceramic Society 2015-08-07

Among patients with vasodilatory shock, gene expression scores may identify different immune states. We aimed to test whether such are robust in identifying patients' state and predicting response hydrocortisone treatment shock.We selected genes generate continuous define previously established subclasses of sepsis. used these a patient's state. evaluated the potential for states assess differential effect two randomized clinical trials versus placebo initially identified associated...

10.1097/shk.0000000000001910 article EN cc-by-nc-nd Shock 2022-01-25

Bulgarelli, Lucas; Kast, Rachel; Ark, Emily Van; Osborn, Jeff; Rey, Diego; Siuba, Matthew; Duggal, Abhijit; Neto, Ary Serpa; Deliberato, Rodrigo Author Information

10.1097/01.ccm.0000810680.58068.53 article EN Critical Care Medicine 2021-12-16

Reduction of healthcare-associated infections (HAIs) is critical to improve patient safety and hospital quality. However, not all HAI-associated outcomes are well studied. We examined several these—the financial length stay (LOS) burden HAIs experience care. National Healthcare Safety Network-reported catheter-associated urinary tract (CAUTI), C. difficile (CDI), central line-associated bloodstream (CLABSI), MRSA bacteremia, colon surgery surgical site (SSI-COLO) were queried for the first 9...

10.1093/ofid/ofy210.1839 article EN cc-by-nc-nd Open Forum Infectious Diseases 2018-11-01

Abstract Background Clinicians considered DDS administration to treat SARS-CoV-2 inflammasome. is helpful in the molecular regulation of Nod-like receptor family pyrin domain-containing 3 (NLRP3). Objective To study targeting NLRP3 itself or up-/downstream factors inflammasome by must be responsible for its observed preventive effects, functioning as a competitor. Methods This randomized controlled trial (RCT). We set out use objective criteria improvement. treated patients with standard...

10.21203/rs.3.rs-509122/v5 preprint EN cc-by Research Square (Research Square) 2021-06-14

ABSTRACT Rationale The acute respiratory distress syndrome (ARDS) is a heterogenous condition, and identification of subphenotypes may help in better risk stratification. Objectives Identify ARDS using new simpler methodology readily available clinical variables. Design Retrospective Cohort Study trials. Setting Data from the U.S. ARDSNet trials international ART trial. Participants 3763 patients datasets 1010 dataset. Primary secondary outcome measures primary was 60-day or 28-day...

10.1101/2021.07.08.21260102 preprint EN medRxiv (Cold Spring Harbor Laboratory) 2021-07-08

Kast, Rachel1; Bulgarelli, Lucas1; Van Ark, Emily1; Osborn, Jeff1; Rey, Diego2; Duggal, Abhijit3; Siuba, Matthew4; Biasi, Alexandre5; Zampieri, Fernando6; Maia, Israel5; Paisani, Denise5; Laranjeira, Ligia5; Neto, Ary Serpa7; Deliberato, Rodrigo1 Author Information

10.1097/01.ccm.0000806516.49603.81 article EN Critical Care Medicine 2021-12-16
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