A5057535967- Neuroinflammation and Neurodegeneration Mechanisms
- Sleep and Wakefulness Research
- Parkinson's Disease Mechanisms and Treatments
- Genetics and Neurodevelopmental Disorders
- Adenosine and Purinergic Signaling
- Neurological Disease Mechanisms and Treatments
- Regulation of Appetite and Obesity
- Circadian rhythm and melatonin
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Sleep and related disorders
- Neurological disorders and treatments
- Adolescent and Pediatric Healthcare
- Nuclear Receptors and Signaling
- Stress Responses and Cortisol
- Antioxidant Activity and Oxidative Stress
- Endoplasmic Reticulum Stress and Disease
- RNA regulation and disease
- Mitochondrial Function and Pathology
- Neurological Complications and Syndromes
- Plant Toxicity and Pharmacological Properties
- Alzheimer's disease research and treatments
- Calcium signaling and nucleotide metabolism
- Sirtuins and Resveratrol in Medicine
- Animal Nutrition and Physiology
University of Belgrade
2011-2025
University of Veterinary Medicine Hannover, Foundation
2021-2025
MRC Protein Phosphorylation and Ubiquitylation Unit
2022
University of Dundee
2022
University of Minnesota
2016-2019
Christie's
2019
Minneapolis VA Health Care System
2019
Geriatric Research Education and Clinical Center
2019
Vinča Institute of Nuclear Sciences
2014
MRC Laboratory of Molecular Biology
2014
Background Sleep disturbances often precede motor symptoms in neurodegenerative diseases like Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Neuroinflammation is implicated PD pathophysiology may contribute to non-motor such as sleep disturbances. The Thy1-αSyn mouse model, overexpressing human alpha-synuclein (αSyn), mimics key aspects of DLB, making it valuable for studying related neuroinflammatory changes. Objective To investigate early-stage alterations architecture,...
Parkinson's disease (PD), classically defined as a progressive motor disorder accompanied with dopaminergic neuron loss and presence of Lewy bodies, is the second most common neurodegenerative disease. PD also has various non-classical symptoms, including cognitive impairments. In addition, inflammation astrogliosis are recognized an integral part pathology. The hippocampus (Hipp) brain region involved in cognition memory, neuropeptide orexin been shown to enhance learning memory. Previous...
Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are chronic inflammatory demyelinating neurodegenerative diseases of the CNS. Although neurodegeneration is major contributor to disability in MS, mechanisms governing viability axons neurons MS EAE remain elusive. Data indicate that activation pancreatic endoplasmic reticulum kinase (PERK) influences, positively or negatively, neuron axon various through induction ATF4. In this study, we...
In Parkinson's disease (PD), the second most common neurodegenerative disorder, non-motor symptoms often precede development of debilitating motor and present a severe impact on quality life. Lewy bodies containing misfolded α-synuclein progressively develop in neurons throughout peripheral central nervous system, which may be correlated with early symptoms. Among those, increased fear anxiety is frequent PD thought to result from pathology outside dopaminergic has been focus symptomatic...
Synthetic glucocorticoid dexamethasone ( DEX ), a highly potent anti‐inflammatory and immunosuppressive agent, is widely used in the treatment of brain cancer, as well for inflammatory autoimmune diseases. The present study aimed to determine whether low‐dose subchronic (100 μg/kg eight consecutive days) exerts long‐term effects on apoptosis adult rat prefrontal cortex PFC ) by examining expression cell death‐promoting molecules [poly( ADP ‐ribose) polymerase PARP p53, procaspase 3, cleaved...
Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are inflammatory demyelinating neurodegenerative diseases of the CNS. Although recent studies suggest neuroprotective effects oligodendrocytes in diseases, it remains unknown whether oligodendrocyte death induced by attacks contributes to neurodegeneration MS EAE. Upon endoplasmic reticulum (ER) stress, activation pancreatic ER kinase (PERK) promotes cell survival through induction activating...
Parkinson's disease (PD) is the second most common neurodegenerative disease. PD symptomology recognized as heterogeneous and in addition to motor function decline, includes cognitive, mood, sleep metabolic disorders. Previous studies showed early reductions anxiety locomotion A53T mice model of PD. Since inflammation astrogliosis are an integral part pathology impair proper neuronal function, we were keen investigate if behavioral changes accompanied by increased Hippocampus (Hipp) cortex...
Abstract Background Venglustat is a brain‐penetrant, small molecule inhibitor of glucosylceramide synthase used in clinical testing for treatment Parkinson's disease (PD). Despite beneficial effects certain cellular and rodent models, patients with PD mutations GBA , the gene lysosomal glucocerebrosidase, experienced worsening their motor function under venglustat (NCT02906020, MOVES‐PD, phase 2 trial). Objective The objective this study was to evaluate mouse models overexpression wild‐type...
Multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE) are inflammatory demyelinating neurodegenerative diseases in the central nervous system (CNS). It is believed that MS EAE initiated by autoreactive T lymphocytes recognize myelin antigens; however, mechanisms responsible for neurodegeneration these remain elusive. Data indicate vascular endothelial growth factor A (VEGF-A) plays a role development of EAE. Interestingly, VEGF-A regarded as...
Aging affects numerous physiological processes, as well behavior. A large number of these processes are regulated, at least partially, by hypothalamic orexin neurons, and tone may decrease with normal aging. In this study, we hypothesized that designer receptors exclusively activated drugs (DREADD) stimulation neuronal activity will ameliorate the effect aging on behavioral metabolic alterations in young middle-aged mice. DREADD targeting was achieved stereotaxic injection AAV vectors...
Aside from the classical motor symptoms, Parkinson's disease also has various non-classical symptoms. Interestingly, orexin neurons, involved in regulation of exploratory locomotion, spontaneous physical activity, and energy expenditure, are affected Parkinson's. In this study, we hypothesized that Parkinson's-disease-associated pathology affects neurons therefore impairs functions they regulate. To test this, used a transgenic animal model Parkinson's, A53T mouse. We measured body...
Alpha-synuclein pathology driven impairment in adult neurogenesis was proposed as a potential cause of, or at least contributor to, memory observed both patients and animal models of Parkinson’s disease (PD) Dementia with Lewy Bodies (DLB). Mice overexpressing wild-type alpha-synuclein under the Thy-1 promoter (Thy1-aSyn, line 61) uniquely replicate early cognitive deficits together multiple other characteristic motor non-motor symptoms, dopamine loss. Here we report overt intracellular...