A5053357658- Neurogenesis and neuroplasticity mechanisms
- Toxoplasma gondii Research Studies
- Veterinary Oncology Research
- Parasitic Infections and Diagnostics
- Infectious Diseases and Mycology
- Herpesvirus Infections and Treatments
- Birth, Development, and Health
- Fetal and Pediatric Neurological Disorders
- Neurological disorders and treatments
- MicroRNA in disease regulation
- Prenatal Screening and Diagnostics
- Congenital heart defects research
- Axon Guidance and Neuronal Signaling
- RNA Interference and Gene Delivery
- Neuroscience and Neuropharmacology Research
- Nuclear Receptors and Signaling
- Neonatal and fetal brain pathology
- Sex work and related issues
- Antimicrobial Peptides and Activities
- Rabies epidemiology and control
- Antimicrobial agents and applications
- Genetics, Aging, and Longevity in Model Organisms
- Parkinson's Disease Mechanisms and Treatments
- Developmental Biology and Gene Regulation
- Advanced Neuroimaging Techniques and Applications
Leipzig University
2014-2025
Max Planck Institute of Molecular Cell Biology and Genetics
2010-2020
Max Planck Society
2010
The expansion of the neocortex during mammalian brain evolution results primarily from an increase in neural progenitor cell divisions its two principal germinal zones development, ventricular zone (VZ) and subventricular (SVZ). Using mRNA sequencing, we analyzed transcriptomes fetal human embryonic mouse VZ, SVZ, cortical plate. In mouse, transcriptome SVZ was more similar to that plate than whereas opposite case, with inner outer being highly related each other despite their...
RNA interference (RNAi)-based strategies that mediate the specific knockdown of target genes by administration small interfering RNAs (siRNAs) could be applied for treatment presently incurable neurodegenerative diseases such as Parkinson's disease. However, inefficient delivery siRNA into neurons hampers in vivo application RNAi. We have previously established 4-12 kDa branched polyethylenimine (PEI) F25-LMW with superior transfection efficacy vivo. Here, we present complexed this PEI...
Abstract A recently discovered source for infection of slaughter pigs, and thus entry bacteria into the food chain, is installed drinking equipment in lairage pens pig abattoirs. To mitigate this, nano-coating stainless steel, currently used human medicine fields as well other parts appears promising technology. In this study, silicon dioxide was applied to six drinkers one three months a abattoir, while results were compared with those that had not been nano-coated. Laboratory examination...
Toxoplasma gondii is a protozoan parasite in cats that can be cause of zoonotic concern due to sheding infectious and highly resistant oocysts. Clinical toxoplasmosis rare occur with mild severe clinical signs or even fatal outcomes. T. immunoglobulin M (IgM) IgG an indicator ongoing prior infection. Information about occurrence the domestic cat population, primary concerns affected cats, potential risk factors scarce Germany. This retrospective study explored data from 174 feline patients...
Introduction Klebsiella pneumoniae (K. pneumoniae) is a major human nosocomial infectious agent and an important veterinary pathogen, frequently resistant to various antibiotics. It causes diseases such as pneumonia, urinary tract infections, surgical wound infections septicemia. Biofilm formation of K. promotes persistent infection contributes resistance against antimicrobial agents. The objective this study was comparatively evaluate the effect selected AMPs on formation, metabolic...
Cryptococcosis and cryptococcal meningitis, caused by
A hallmark of mammalian brain evolution is the emergence neocortex, which has expanded in all infraclasses (Eutheria, Marsupialia, Monotremata). In eutherians, neocortical neurons derive from distinct neural stem and progenitor cells (NPCs). However, precise data on presence abundance NPCs, especially basal radial glia (bRG), neocortex marsupials are lacking. This study characterized quantified NPCs developing a marsupial, tammar wallaby (Macropus eugenii). Our demonstrate that its by high...
Mammals are born on a precocial-altricial continuum. Altricial species produce helpless neonates with closed distant organs incapable of locomotion, whereas precocial give birth to well-developed young that possess sophisticated sensory and locomotor capabilities. Previous studies suggest distinct patterns cortex development differ between altricial species. This study compares neocortex neurogenesis maturation in the guinea pig dwarf rabbit, both belonging taxon Glires. We show principal...
The neocortex plays a key role in cognition, volitional motor control and sensory perception has undergone tremendous expansion during evolution. mature consists of radially aligned neurons that are arranged six layers. Layers II-VI often split into two groups: deep upper layers, both building up the so-called cortical plate embryonic foetal development. So far neurogenesis, including generation mostly been studied laboratory rodents primates. However, precise data for most companion animals...
The neocortex is the most complex part of mammalian brain and as such it has undergone tremendous expansion during evolution, especially in primates. majority neocortical neurons originate from distinct neural stem progenitor cells (NPCs) located ventricular subventricular zone (SVZ). Previous studies revealed that SVZ thickness well abundance distribution NPCs, basal radial glia (bRG), differ markedly between lissencephalic rodent gyrencephalic primate neocortex. northern tree shrew (Tupaia...
Chronic inflammatory enteropathies (CIEs) are an important group of diseases in dogs and involve complex pathogenetic aspects. Endoscopy histopathology vital for documenting the disease but less useful subclassifying CIEs predicting response to treatment. However, healing mucosal process (deep remission) ultrastructural evaluation mucosa have received little attention canine CIE. Given that CIE shares many similarities with bowel (IBDs) human patients—and presents a good spontaneous model...
Alpha-synuclein pathology driven impairment in adult neurogenesis was proposed as a potential cause of, or at least contributor to, memory observed both patients and animal models of Parkinson’s disease (PD) Dementia with Lewy Bodies (DLB). Mice overexpressing wild-type alpha-synuclein under the Thy-1 promoter (Thy1-aSyn, line 61) uniquely replicate early cognitive deficits together multiple other characteristic motor non-motor symptoms, dopamine loss. Here we report overt intracellular...
Abstract Background Toxoplasma gondii is an obligate intracellular parasite with a worldwide distribution. Congenital infection in humans and animals may lead to severe symptoms the offspring, especially brain. A suitable animal model for human congenital toxoplasmosis currently lacking. The aim of this study establish validate guinea pig as by investigating impact T. dose, duration gestational stage at on seroconversion, survival rate dams, fate DNA loads various offspring tissues organs...
is an obligate intracellular parasite with felids, including domestic cats, as definitive hosts. In immunocompetent individuals,
Open spina bifida (OSB) is one of the most prevalent congenital malformations CNS that often leads to severe disabilities. Previous studies reported volume and thickness neocortex be altered in children adolescents diagnosed with OSB. Until now, onset underlying cause atypical organization OSB patients remain largely unknown. To examine effects on fetal development, we analyzed human fetuses both sexes between 11 15 weeks gestation by immunofluorescence for established neuronal neural...
Saliva is essential for the proper dilution and distribution of taste molecules on tongue. It harbors extracellular vesicles (EVs), which mediate cell-cell communication. Changes in composition salivary EVs may arise under obese conditions potentially be involved sensation dysregulated eating behavior. Therefore, this study addresses relationship between size concentration metabolic shifts obesity or factors sensation. A total 119 participants Obese Taste Bud (OTB) Study were included, who...
Abstract The Greater cane rat (GCR, Thyronomys swinderianus ) is a precocial rodent predominantly found within Africa. Economic and scientific interests have led to several research efforts towards the domestication better understanding of biology development this rodent. Despite these efforts, information on pre‐natal currently lacking. This study characterises distinct developmental milestones including skin pigmentation, emergence distributions hairs, calvarium consistency, teeth...
Tastbare Veränderungen in der Haut- und Unterhaut sind ein häufiger Grund für einen Besuch Kleintierpraxis. Leider wird ihre potenzielle Bösartigkeit häufig unterschätzt, sodass eine Therapie zu einem späteren Zeitpunkt nicht mehr zur Heilung des Patienten führt. Aus klinischer Sicht ist minimalinvasive Schnelldiagnostik sinnvoll, die dem Praktiker wichtige Entscheidungshilfe das weitere Vorgehen bietet.
To evaluate fetal cerebral cortex development at 11-15 weeks of gestation in human fetuses with posterior brain abnormalities (BS-BSOB-ratio >95th centile, CM <5th centile) and confirmed diagnosis neural tube defects such as open spina bifida during their 11-13-week scan, to compare it normal development. Pregnant women were referred our first trimester clinic for measurement nuchal translucency combined risk assessment adverse pregnancy outcomes. In case some patients decided terminate...