A5100719609- Cutaneous lymphoproliferative disorders research
- melanin and skin pigmentation
- Genetic and rare skin diseases.
- Hippo pathway signaling and YAP/TAZ
- Herpesvirus Infections and Treatments
- Cutaneous Melanoma Detection and Management
- Cancer-related gene regulation
- Fungal Infections and Studies
- Dermatological and Skeletal Disorders
- Genital Health and Disease
- Caveolin-1 and cellular processes
- RNA regulation and disease
- Medicinal Plant Pharmacodynamics Research
- Cancer-related molecular mechanisms research
- Urological Disorders and Treatments
- Cancer Cells and Metastasis
- CAR-T cell therapy research
- Hair Growth and Disorders
- Poxvirus research and outbreaks
- Urologic and reproductive health conditions
Tianjin Children's Hospital
2015-2023
Tianjin University
2023
The University of Texas MD Anderson Cancer Center
2020
China Medical University
2016
First Hospital of China Medical University
2016
Peritoneal carcinomatosis (PC; malignant ascites or implants) occurs in approximately 45% of advanced gastric adenocarcinoma (GAC) patients and associated with a poor survival. The molecular events leading to PC are unknown. yes-associated protein 1 (YAP1) oncogene has emerged many tumour types, but its clinical significance is unclear. Here, we investigated the role YAP1 potential as therapeutic target.Patient-derived cells, patient-derived xenograft (PDX) orthotopic (PDO) models were used...
To investigate the correlation between Nodal and YAP1 expression clinicopathological characteristics of gastric adenocarcinoma (GAC). Quantitative real-time RT-PCR, Western blot, immunohistochemistry were performed to measure mRNA protein in 20 fresh frozen samples 220 paraffin-embedded GAC tissues with their paired non-tumor mucosa (PNTM). The prognostic values evaluated 161 patients using univariate multivariate analyses. Both significantly increased compared PNTM (P < 0.05)....
Abstract Background Molluscum contagiosum (MC), milia, keratosis pilaris (KP), verruca plana (VP), seborrheic (SK), and juvenile xanthogranuloma (JXG) are common papule dermatoses on the face of children that have a similar appearance. In vivo evaluation facial with reflectance confocal microscopy (RCM) is helpful in diagnosis these ambiguous lesions children. The purpose this study was to clarify RCM characteristics MC, KP, VP, SK, JXG explore clinical application value for dermatoses....
Vulvar lichen sclerosus (VLS) is a chronic inflammatory dermatosis of unknown pathogenesis, characterized by porcelain-white atrophic plaques around the vulvar and anal areas in girls. With this communication, we performed study on 16 female girls with clinically histologically confirmed VLS, described main identifying characteristics lesions reflectance confocal microscopy (RCM) elucidated corresponding relationship between RCM findings histology. We recommend RCM, noninvasive technique, as...
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy arising from precursor cells. It and challenging clinical presentation. For decades, there has been no treatment course for managing BPDCN its overall prognosis poor.
Abstract Mastocytosis, lichen planus pigmentosus (LPP), fixed drug eruption (FDE) and café-au-lait macules (CALM) have a similar appearance, often lead to misdiagnosis missed diagnoses. At the outpatient clinic at Tianjin Children’s Hospital in 21 patients with mastocytosis, 18 LPP, 11 FDE 12 CALM we evaluated characteristics distinguishing features of their dermatoses using reflectance confocal microscopy (RCM). In dermal papillary rings generally had significantly increased bright...
Alopecia areata (AA), trichotillomania (TM), nevus sebaceous (NS), and linear scleroderma en coup de sabre (LSCS) can all present with a patch of alopecia, making diagnosis challenging. The purpose this study was to combine reflectance confocal microscopy (RCM) dermoscopy in the these lesions children.
To study the efficacy of Huaiqihuang granules as adjuvant therapy for bronchial asthma in children.A multicenter, prospective, and registered real-world was performed children, aged 2-5 years, who had a confirmed diagnosis outpatient service 21 hospitals China. Among these children treated with medications long-term control (inhaled corticosteroid and/or leukotriene receptor antagonist) without were enrolled treatment group, those combined group. The medical data all collected. Outpatient or...
Objective To evaluate the clinical application value of reflectance confocal microscopy (RCM) in diagnosis several common diseases manifesting as papules children, including lichen nitidus, verruca planae, striatus, milium, molluscum contagiosum and pilaris. Methods A total 579 children clinically characterized by were recruited into this study. RCM was used to observe lesions perilesional normal skin. The features 6 analyzed compared. Results Based on images, 236 patients...
Objective To investigate the microscopic features of common hypopigmentation disorders using confocal laser scanning microscopy (CLSM). Methods Totally, 1915 child patients with were enrolled in this study, including 181 cases vitiligo, 38 idiopathic guttate hypomelanosis, 370 amelanotic nevus, 304 lichen striatus, 712 pityriasis alba, and 310 postinflammatory hypopigmentation. CLSM was performed to observe all layers depigmented lesions, their borders, normal-appearing perilesional...