A5100771151- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Retinoids in leukemia and cellular processes
- COVID-19 and Mental Health
- Nuclear Structure and Function
- Health and Well-being Studies
- Nanoplatforms for cancer theranostics
- Inflammatory Biomarkers in Disease Prognosis
- Cancer-related molecular mechanisms research
- Health disparities and outcomes
- Healthcare professionals’ stress and burnout
- Microscopic Colitis
- Hippo pathway signaling and YAP/TAZ
- Neurological Disorders and Treatments
- Cancer, Lipids, and Metabolism
- Estrogen and related hormone effects
- Cancer-related gene regulation
- Long-Term Effects of COVID-19
- Neurological Disease Mechanisms and Treatments
- Helicobacter pylori-related gastroenterology studies
- Biotin and Related Studies
- Inflammatory Bowel Disease
Chiba University
2020-2025
Liaoning Cancer Hospital & Institute
2025
Changhai Hospital
2019-2021
Second Military Medical University
2019-2021
Lanzhou University
2020-2021
Lanzhou University Second Hospital
2020-2021
Renmin University of China
2020
China Medical University
2010-2016
First Hospital of China Medical University
2016
The outbreak of novel coronavirus pneumonia (COVID-19) has brought enormous physical and psychological pressure on Chinese medical staff. It is extremely important to understand the prevalence influencing factors anxiety depression symptoms in first-line anti-epidemic staff their coping styles for these negative emotions.A cross-sectional survey was conducted Gansu (China), with a questionnaire packet which consisted self-rating scale (SAS), (SDS), simplified style (SCSQ). A total 79 doctors...
Abstract The impact of the COVID-19 pandemic on clinically stable older patients with psychiatric disorders is unclear. This study examined prevalence depressive and anxiety symptoms, their associations quality life (QOL) in during pandemic. was a multicenter, cross-sectional study. Depressive insomnia, pain, QOL were assessed standardized instruments. A total 1063 included. combined symptoms 62.3% (95%CI = 59.4–65.2%), 52.4% 49.3–55.4%), 45.9% 42.9–48.9%), respectively. Patients had...
Abstract Background Circulating exosomal microRNAs are an easily obtained and minimally invasive biomarker for cancer treatment. Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive carcinomas. It would thus be extremely crucial to predict therapeutic sensitivity patient prognosis in advance. Methods A search miRNAs with a ESCC was performed using miRNA expression signatures from plasma exosomes before chemoradiotherapy. miR-191-5p selected based on comparison findings...
Abstract Background The differential diagnosis of pancreatic ductal adenocarcinoma (PDAC) from chronic pancreatitis (CP) is clinically challenging due to a lack minimally invasive methods. MicroRNAs (miRNAs) derived small extracellular vesicles (EVs) in the blood have been reported as promising biomarker for various types cancer. However, EV miRNA signatures and their diagnostic value differentiate between PDAC CP remain be determined. Methods In this study, 107 patients with or were...
To investigate the correlation between Nodal and YAP1 expression clinicopathological characteristics of gastric adenocarcinoma (GAC). Quantitative real-time RT-PCR, Western blot, immunohistochemistry were performed to measure mRNA protein in 20 fresh frozen samples 220 paraffin-embedded GAC tissues with their paired non-tumor mucosa (PNTM). The prognostic values evaluated 161 patients using univariate multivariate analyses. Both significantly increased compared PNTM (P < 0.05)....
From 2001 to 2015, medical data of 16 856 elderly patients aged 65 years and over who used Suxiao Jiuxin Pills in the information system 37 tertiary A-level hospitals were collected. After standardized analysis, it was found that average age 72.48 years, main admission departments department cardiology(19.30%) geriatric department(9.77%). Generally, 61.96% degree illness is average, hospitalized days 16.16 days; 47.97% diagnosed as coronary heart disease by Western medicine, 5.86% Qi...
Despite advances in treatment and diagnosis, the prognosis of patients with esophageal squamous cell carcinoma (ESCC) remains poor. MicroRNAs (miRNAs/miRs) are associated cancer, indicating that they may help guide decisions. The aim present study was to explore exosomal miR-185 as a candidate prognostic biomarker therapeutic target ESCC, investigate its biological function clinical significance, ascertain applicability circulating for development targeted drugs ESCC treatment. A GeneChip...
Abstract Background: Exosomes are nano-sized extracellular vesicles and detectable in most body fluids. Circulating exosomal microRNAs an easily obtained, they could be minimally invasive biomarker for cancer treatment. Esophageal squamous cell carcinoma (ESCC) is one of the aggressive carcinomas. Radiotherapy important treatment option ESCC, it would thus extremely crucial to predict therapeutic sensitivity patient prognosis advance. Methods: A search miRNAs with a ESCC was performed using...
Objective To study the renal toxicity of arsenic trioxide (As2O3) with therapeutic dose in acute promyelocytic leukemia (APL) childhood. Methods Renal 37 APL was monitored. The examinations urinary routine, microproteins[αt1-microglobulin (α1-MG), microalbumin (mAlb),β2-microglobulin (β2-MG), transferrin(TRF)] and function were performed. Results Five cases leukocyturia, three hematuria, six proteinuria observed before therapy. Ketonuria occurred associated fever less diet; overall...
Purpose: Pancreatic ductal adenocarcinoma (PDAC) is of high mortality with a shortage effective non-invasive biomarkers in the diagnosis and prognosis. Without proper method to identify reasonable target molecules their references for normalization, robust accurate blood miRNA have not been reported. We aim explore exosomal miRNAs as prognosis PDAC sufficient biological insights robustness.Materials Methods: miRNA-seq was performed on extracted from exosomes. 16 non-metastatic PDAC, 11...