A5009815667- Electrospun Nanofibers in Biomedical Applications
- Proteins in Food Systems
- Advanced Cellulose Research Studies
- Nerve injury and regeneration
- Biochemical Analysis and Sensing Techniques
- RNA Interference and Gene Delivery
- Biosensors and Analytical Detection
- Healthcare and Environmental Waste Management
- Enzyme Catalysis and Immobilization
- Electrochemical sensors and biosensors
- Advanced biosensing and bioanalysis techniques
- Wound Healing and Treatments
- Neuroscience and Neural Engineering
- Advanced Drug Delivery Systems
- Polysaccharides and Plant Cell Walls
International Iberian Nanotechnology Laboratory
2023-2024
University of Minho
2020-2021
Identifying grape varieties in wine, related products, and raw materials is of great interest for enology to ensure its authenticity. However, these matrices' complexity low DNA content make this analysis particularly challenging. Integrating with 2D materials, such as graphene, offers an advantageous pathway toward ultrasensitive detection. Here, we show that monolayer graphene provides optimal test bed nucleic acid detection single-base resolution. Graphene's ultrathinness creates a large...
Abstract Metallic implants are widely used in diverse clinical applications to aid recovery from lesions or replace native hard tissues. However, the lack of integration metallic surfaces with soft tissue interfaces causes occurrence biomaterial‐associated infections, which can trigger a complicated inflammatory response and, ultimately, implant failure. Here, multifunctional surface showing nanoscale anisotropy, based on controlled deposition cellulose nanocrystals (CNC), and biological...
Abstract Reliable in-vitro digestion models that are able to successfully replicate the conditions found in human gastrointestinal tract key assess fate and efficiency of new formulations aimed for oral consumption. However, current either lack capability crucial dynamics or require large volumes sample/reagents, which can be scarce when working with nanomaterials under development. Here, we propose a miniaturised system, digestion-chip, based on incubation chambers integrated...
Cellulose nanocrystals can bind different patterns of platelet lysate-derived protein in a surface sulfation dependent manner. The potential to direct stem cell fate by solid-phase presentation defined coronas is demonstrated.
Reliable in-vitro digestion models that are able to successfully replicate the conditions found in human gastrointestinal tract (GIT) key assess fate and efficiency of new formulations aimed for oral consumption. However, current either lack capability crucial dynamics or require large volumes sample/reagents, which can be scarce when working with nanomaterials under development. Here, we propose a miniaturised system, digestion-chip, based on incubation chambers integrated...
Abstract Neurological disorders, a leading global cause of death, encompass conditions affecting the peripheral and central nervous systems (PNS CNS, respectively). Limited axon regeneration is significant challenge in these it linked to proteins like PTEN. RNA-based therapeutics, particularly siRNAs, hold potential for silencing inhibitory pathways, but their clinical application hindered by poor stability cellular uptake. Our study addressed this with development novel, fully biodegradable...
Gene therapy using small interfering RNA (siRNA) holds promise for treating neurological disorders by silencing specific genes, such as the phosphatase and tensin homolog ( PTEN ) gene, which restricts axonal growth. Yet, delivering siRNA to neurons efficiently is challenging due premature degradation unspecific delivery. Chitosan-based delivery systems have shown great potential their well-established biocompatibility. However, limited transfection efficiency lack of neuronal tropism...