A5076625495- Kidney Stones and Urolithiasis Treatments
- Porphyrin Metabolism and Disorders
- Tea Polyphenols and Effects
- Tryptophan and brain disorders
- Genomics, phytochemicals, and oxidative stress
- Morinda citrifolia extract uses
- Medicinal Plants and Neuroprotection
- Antioxidant Activity and Oxidative Stress
- Phytochemicals and Antioxidant Activities
- Atherosclerosis and Cardiovascular Diseases
- Therapeutic Uses of Natural Elements
- Chronic Kidney Disease and Diabetes
- Berberine and alkaloids research
- Plant-based Medicinal Research
- Bone and Dental Protein Studies
- Erythrocyte Function and Pathophysiology
- Computational Drug Discovery Methods
- Vitamin C and Antioxidants Research
- Biomedical Research and Pathophysiology
- Heme Oxygenase-1 and Carbon Monoxide
- HIV/AIDS drug development and treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Drug-Induced Hepatotoxicity and Protection
- Pharmacological Effects and Toxicity Studies
- Histone Deacetylase Inhibitors Research
University of Madras
2014-2024
Bharathiar University
2012
University of Miami
2004
Abstract Objectives Oxidative stress is recognized as a key element responsible for the development of age-related pathologies. A declining endogenous defence system during senescence dictates need supplementation with exogenous antioxidants through diet. Hesperidin naturally occurring flavonone present in citrus fruits and has been shown to have many biological properties, including antioxidant activity. We investigated whether hesperidin could be valuable protecting cardiac tissue aged...
Abstract Aging is a complex biological phenomenon which involves free radicals and oxidative stress. Brain more susceptible vulnerable to damage due its high‐polyunsaturated fatty acid content high rate of aerobic metabolism. Since the antioxidant defense system diminished during aging, supplementation might be protective strategy against age‐associated damage. The present study evaluates potential (−)‐epigallocatechin‐3‐gallate (EGCG), major polyphenol in green tea rat brain. Male albino...
Apoptosis is an active response of cells to altered microenvironments, which characterized by cell shrinkage, chromatin condensation, and DNA fragmentation, in a variety types such as renal epithelial cells, endothelial mesangial podocytes. Hyperglycemia among the microenvironmental factors that may facilitate apoptosis, plays decisive role initiation diabetic nephropathy. Transforming growth factor-β emerges powerful fibrogenic factor development hypertrophy. Although, number potential...
Given the role of oxidative stress in PD pathogenesis and off-target side effects currently available drugs, several natural phytochemicals seem to be promising management PD. Here, we tested hypothesis that scopoletin, an active principle obtained from Morinda citrifolia (MC), efficiently quenches through DJ-1/Nrf2 signaling ameliorates rotenone-induced Despite reducing stress, administration MC extract (MCE) has lessened protein aggregation as evident decreased levels nitrotyrosine...
The sol-gel method was used to synthesize TiO₂ nanoparticles, which were then characterized by powder XRD, SEM, EDS, and spectroscopy. benzohydrazide derivatives (1-4) synthesized utilizing sol-gel-produced (R) as a catalyst in solvent environment FT-IR, NMR, mass spectrum analyses. Antimicrobial tests conducted against bacterial strains such E. coli, S. typhi, aureus P. aeruginosa, well fungal C. albicans, A. niger, Mucor Rhizopus sp.
Abstract Aging is a multi‐factorial process which involves deprivation in body's metabolism. Brain mitochondria are prone to oxidative damage owing their high metabolic rate. The decline antioxidant system during aging augments the neuronal mitochondrial components like system, Kreb's cycle enzymes and electron transport chain complexes. Since brain an organ rich fatty acids, lipid peroxidation products hydroxynonenal predominant. Those conjugate with amino acids form adducts alter...
Background . Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is the major receptor for (Ox-LDL) in aorta of aged rats. Ox-LDL initiates LOX-1 activation endothelium lipid-accumulating sites both animal and human subjects hypercholesterolemia. Targeting may provide a novel diagnostic strategy towards hypercholesterolemia vascular diseases. Hypothesis This study was planned to address whether aegeline (AG) could bind with higher affinity modulate uptake Study Design Thirty-six...
Cardiac hypertrophy is the underlying cause of heart failure and characterized by excessive oxidative stress leading to collagen deposition. Therefore, understanding signalling mechanisms involved in extracellular matrix deposition necessary prevent cardiac remodelling failure. In this study, we hypothesized that hesperetin, a flavanone elicits activation Nrf2 thereby suppresses stress, mediated pathological progression. A model was established with subcutaneous injection isoproterenol male...
Background. This study aimed to assess the therapeutic efficacy of oral vitamin E supplementation on biochemical and kinetic properties Tamm–Horsfall glycoprotein (THP) in hypertensive hyperoxaluric patients. Methods. Newly detected hypertensives (n = 200) stone formers were each subdivided into two groups. One group 100) was administered antioxidant at 400 mg/day given as an supplement along with standard drugs for hypertension hyperoxaluria patients followed a period 9 months. The other...
Parkinson disease (PD) is a neurodegenerative disorder affecting mainly the motor system, as result of death dopaminergic neurons in substantia nigra pars compacta. The present scenario research PD directed to identify novel molecules that can be administered individually or co-administered with L-Dopa prevent L-Dopa-Induced Dyskinesia (LID) like states arise during chronic administration. Hence, this study, we investigated whether Morinda citrifolia has therapeutic effects rotenone-induced...