Major impediments to technology scaling in the nanometer regime include power (or energy) dissipation and "erroneous" behavior induced by process variations noise susceptibility. In this paper, we demonstrate that CMOS devices whose is rendered probabilistic (yielding or PCMOS) can be harnessed for ultra low energy high performance computation. PCMOS are inherently they guaranteed compute correctly with a probability 1= 2< p< 1 thus, design, expected incorrectly (1 p). show yields...

We develop a theoretical foundation to characterize novel methodology for low energy and high performance dsp embedded computing. Computing elements are operated at frequency higher than that permitted by conventionally correct circuit design, enabling trade-off between error is deliberately introduced, the consumed. Similar techniques considered previously were relevant deeply scaled future technology generations. Our work extends this idea be applicable current-day designs through: (i)...

The central theme of our work is the probabilistic and approximate design embedded computing systems. This novel approach consists two distinguishing aspects: (i) implementation systems, using components which are susceptible to perturbations from various sources (ii) a methodology an exploration space characterizes trade-off between quality output cost, implement high performance low energy In contrast with other work, does not attempt correct errors introduced by perturbations, instead we...

Parameter variations, noise susceptibility, and increasing energy dissipation of cmos devices have been recognized as major challenges in circuit microarchitecture design the nanometer regime. Among these, parameter variations susceptibility are increasingly causing to behave an “unreliable” or “probabilistic” manner. To address these challenges, a shift paradigm from current-day deterministic designs “statistical” is deemed inevitable. respond this need, article, we introduce study entirely...

Apoptosis is an active response of cells to altered microenvironments, which characterized by cell shrinkage, chromatin condensation, and DNA fragmentation, in a variety types such as renal epithelial cells, endothelial mesangial podocytes. Hyperglycemia among the microenvironmental factors that may facilitate apoptosis, plays decisive role initiation diabetic nephropathy. Transforming growth factor-β emerges powerful fibrogenic factor development hypertrophy. Although, number potential...

Abstract Introduction: Ovarian cancer (OC) remains the deadliest gynecologic malignancy, with minimal improvement in 5-year survival rate over past three decades despite advancements treatment. High-grade serous ovarian (HGSOC) is characterized by aggressive progression, driven elevated secretion of extracellular vesicles (EVs), tumor-associated macrophage (TAM) activation, and increased myeloid-derived suppressor cell (MDSC) populations. These factors contribute to immune suppression,...

Abstract Introduction: Endometrial cancer (EC) is the most common gynecologic malignancy in U.S., with obesity contributing to 57% of cases. This study investigates molecular mechanisms linking EC, focusing on extracellular vesicle (EV) secretion and oncogenic protein regulation adipose uterine tissues. Understanding these pathways could lead innovative preventive therapeutic strategies for obesity-related EC. Methods: hyperplasia were induced immunocompetent mice using high-fat diets (HFD;...

Noise immunity and low-energy computing have become limiting factors in the semiconductor roadmap as transistor feature sizes shrink. The subject of our study is probabilistic switch, implemented complementary metal–oxide–semiconductor (CMOS) domain, referred to a CMOS (PCMOS) whose behavior rendered by noise. In conducting this study, we are motivated possibility using such switches realize ultra-low energy computing. Based on PCMOS realized 0.5 0.25 µm processes, present detailed...

Background . Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is the major receptor for (Ox-LDL) in aorta of aged rats. Ox-LDL initiates LOX-1 activation endothelium lipid-accumulating sites both animal and human subjects hypercholesterolemia. Targeting may provide a novel diagnostic strategy towards hypercholesterolemia vascular diseases. Hypothesis This study was planned to address whether aegeline (AG) could bind with higher affinity modulate uptake Study Design Thirty-six...

Background: Aegeline (AG) is a natural hydroxyamide which has not been explored in depth for its potential applications food, pharmaceutical, and cosmetic industries. Accordingly, this study, the property of AG as antioxidant, anti-hypercholesterolemic, an anti-aging component was explored. The hepatoprotective effect on hypercholesterolemic rats investigated health care benefits hypocholesterolemic drug vs Atorvastatin (AV) first time.Objective: objective to delineate mechanism action...

Cardiac hypertrophy is the underlying cause of heart failure and characterized by excessive oxidative stress leading to collagen deposition. Therefore, understanding signalling mechanisms involved in extracellular matrix deposition necessary prevent cardiac remodelling failure. In this study, we hypothesized that hesperetin, a flavanone elicits activation Nrf2 thereby suppresses stress, mediated pathological progression. A model was established with subcutaneous injection isoproterenol male...

Highly scaled CMOS devices in the nanoscale regime would inevitably exhibit statistical or probabilistic behavior. Such behavior is due to process variations and other perturbations such as noise. Therefore current circuit design methodologies, which depend on existence of deterministic uniform with no consideration for either power consumption behavior, longer be sufficient robust circuits. To help overcome this challenge, we have been characterizing (probabilistic PCMOS devices) at several...

It is widely acknowledged that even as VLSI technology advances, there a looming crisis an important obstacle to the widespread deployment of mobile embedded devices, namely power. This problem can be tackled at many levels like logic, operating systems, micro-architecture and compiler. While have been various proposals for specific compiler optimizations power, has not any attempt systematically map out space possible improvements. In this paper, we quantitatively characterize limits what...

Parkinson's disease is a progressive neurodegenerative movement disorder with the cardinal symptoms of bradykinesia, resting tremor, rigidity, and postural instability, which lead to abnormal movements lack activity, in turn cause muscular damage. Even though studies have been carried out elucidate causative factors that damage disease, apoptotic events occur skeletal muscle therapeutical approach culminate not extensively studied. Thus, this study evaluates impact rotenone-induced SNPc...

We introduce probabilistic design, a methodology to design circuits using gates with behavior. Probabilistic is of great value, since the international technology roadmap for semiconductors (ITRS) forecasts that devices and interconnect are likely suffer from frequent transient permanent failures, as consequence scaling. first provide theoretical basis rooted in novel Boolean Logic (pbl). By combining properties pbl noise susceptible cmos devices, we derive principles demonstrate viable...

We introduce probabilistic design, a methodology to design circuits using gates with behavior. Probabilistic is of great value, since the international technology roadmap for semiconductors (ITRS) forecasts that devices and interconnect are likely suffer from frequent transient permanent failures, as consequence scaling. first provide theoretical basis rooted in novel Boolean Logic (pbl). By combining properties PBL noise susceptible CMOS devices, we derive principles demonstrate viable...

Type 2 diabetes is delineated by impaired metabolic flexibility, and intramyocellular lipid accumulation, causing insulin resistance, particularly in skeletal muscle reducing insulin-stimulated glucose uptake. High-fat diet high fructose (HFD HF) administration rodents bestows a model for hyperlipidemia, diabetes. The current study focused on elucidating the role of Gymnemic acid combating hyperglycemia mediated oxidative stress apoptotic events HFD HF induced Wistar albino rats boosting...

This paper discusses a set of algorithms for performing Variable Long Precision Arithmetic (VLPA) and their implementation on reconfigurable hardware. These are characterized by high degree similarity, scalability massive parallelism. Due to these features, target provides reduced design time, easy the ability make cost performance tradeoff. Moreover, similarity in data path various opens possibility using partial reconfiguration reduce silicon footprint. Performance figures obtained from...