A5023159797- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- NF-κB Signaling Pathways
- RNA Research and Splicing
- Genomics, phytochemicals, and oxidative stress
- Bladder and Urothelial Cancer Treatments
- Epigenetics and DNA Methylation
- Nutrition, Genetics, and Disease
- Alcohol Consumption and Health Effects
- Otitis Media and Relapsing Polychondritis
- Metabolomics and Mass Spectrometry Studies
- Liver Disease Diagnosis and Treatment
- Polysaccharides and Plant Cell Walls
- RNA modifications and cancer
- Genetic Associations and Epidemiology
- Immunotherapy and Immune Responses
- Tea Polyphenols and Effects
- Folate and B Vitamins Research
- Skin and Cellular Biology Research
- Tracheal and airway disorders
- Trace Elements in Health
- Glycosylation and Glycoproteins Research
- Bacterial biofilms and quorum sensing
- Adipokines, Inflammation, and Metabolic Diseases
Sri Ramachandra Institute of Higher Education and Research
2014-2024
University of Madras
2020
Abstract Genome‐wide association studies (GWAS) have identified an between polymorphisms in the FTO gene and obesity. The : rs9939609, intronic variant, is considered a risk allele for developing diabesity homozygous heterozygous forms. This study aimed to investigate molecular structure of available inhibitors specific mutations along with rs9939609 variant. We best‐suited inhibitor molecules each mutant type containing allele. Missense unique obesity were retrieved from dbSNP this study....
Gastrointestinal (GI) cancers are known to have a high incidence worldwide and require an early diagnosis successfully treat them, providing higher survival rates better quality of life for the patients. MicroRNA-27a is well-known oncogene that plays significant role in various GI cancers. It upregulate expression numerous oncogenes leading cancer progression. The miR-27a harbors two polymorphisms rs895819 rs11671784 which alter disease susceptibility by interfering with maturation miR-27a....
Urothelial carcinoma (UC) is the fifth most common malignancy that accounts for 5% of all cancers. Diagnostic markers predict UC progressions are inadequate. NF-κB contributes towards disease progression upon constitutive activation in many solid tumors. The nuclear localization indicates increased transcriptional activity while cytoplasmic inactive protein repository can be utilized readily by a malignant cell. This study delineates and differential expression heterodimers progression.The...
The cancers of the gastrointestinal (GI) tract have become a common diagnosis worldwide contributing to large number mortalities. Though potentially curable they are mostly fatal due late and lack accurate diagnostic markers. microRNA, micromanagers gene expression been associated distinct roles as oncogenes or tumour suppressors in several including GI cancers. These miRNAs known harbour single nucleotide polymorphisms (SNPs) that lead loss gain its functions found be with altering...
Bladder cancer is a recurrent disease that often develops chemoresistance and on the rise in developing countries. After diagnosis surgery followed by immunotherapy and/or chemo- radiation therapy are available treatments. These treatments do not provide protection against progression or recurrence thus highlighting need to identify develop drugs capable of inhibiting bladder cancer. T24 cell line (human transitional carcinoma) was treated with NEMO Binding Domain (NBD) peptide tested for...
Abstract Alcohol use disorder (AUD) is a multifactorial psychiatric behavior disorder. Disulfiram the first approved drug by Food and Drug Administration for alcohol‐dependent patients, which targets ALDH2 enzyme. Several genes are known to be involved in alcohol metabolism; mutations any of these associated with AUD. The E504K mutation precursor protein or E487K mature (E504K/E487K; ALDH2*2 allele) carried approximately 8% world population. In this study, we aimed test inactive allele...
Archival Formalin-Fixed Paraffin-Embedded (FFPE) tissues are a readily available source of DNA for retrospective studies including genetic predisposition. FFPE present significant challenges extraction pure genomic in adequate amounts due to the harsh fixation conditions and long-term storage associated with samples. The aim study is propose simple, in-expensive, viable protocol from optimize same detection 3’UTR miRNA binding site polymorphism ADAMTS1 gene colorectal cancer normal colonic...