A5091556991- Antimicrobial Peptides and Activities
- Chemical Synthesis and Analysis
- Supramolecular Self-Assembly in Materials
- Polydiacetylene-based materials and applications
- Piperaceae Chemical and Biological Studies
- X-ray Diffraction in Crystallography
- Ion Transport and Channel Regulation
- Click Chemistry and Applications
- Antimicrobial agents and applications
- Crystallization and Solubility Studies
- Ion channel regulation and function
- Liver Disease Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Protein Hydrolysis and Bioactive Peptides
- Traditional and Medicinal Uses of Annonaceae
- Algal biology and biofuel production
- Renal function and acid-base balance
- Signaling Pathways in Disease
- Fibroblast Growth Factor Research
- Steroid Chemistry and Biochemistry
- Tactile and Sensory Interactions
- Genetic Associations and Epidemiology
- Plant-Microbe Interactions and Immunity
- Phenothiazines and Benzothiazines Synthesis and Activities
- Chronic Kidney Disease and Diabetes
Tel Aviv University
2023-2024
Indian Institute of Integrative Medicine
2016-2023
Academy of Scientific and Innovative Research
2016-2023
Council of Scientific and Industrial Research
2021
Indian Institute of Technology Roorkee
2021
Institute of Medicinal Plant Development
2015
Indiana University – Purdue University Indianapolis
2003-2006
Indiana University School of Medicine
2003
Serum HGF is elevated in obese individuals. This study examined the contribution of excess adipose tissue to increased circulating levels obesity. was measured by ELISA before and after weight loss due bariatric surgery or a 24-h fast. At 6.1 +/- 0.1 mo following surgery, BMI (50.6 1.6 vs. 35.1 1.3 kg/m(2); P < 0.0001) serum were significantly decreased (1,164 116 529 39 pg/ml, 0.001). A fast did not change HGF, but leptin reduced (67.7 7.1 50.3 8.3 ng/ml, = 0.02). secretion vitro from...
Bacterial infections pose a serious threat to mankind, and there is immense interest in the design development of self-assembled peptide gels using ultrashort peptides for antibacterial applications. The containing natural amino acids suffer from poor stability against proteolytic enzymes. Therefore, need develop with improved In present work, we report synthesis characterization α/γ hybrid Boc-D-Phe-γ4-L-Phe-PEA (NH007) Boc-L-Phe-γ4-L-Phe-PEA (NH009) improve stability. Both dipeptides were...
The present work describes the anti-invasive effect of conjugate BC06, a novel EPA, (2E,4E)-4-(benzo[d][1,3]dioxol-5-ylmethylene) hex-2-enoic acid with β,β-disubstituted-β-amino acid, β3,3-Pip-OH (2-(4-aminopiperidin-4-yl)acetic acid), in human pancreatic carcinoma. BC06 inhibited invasion and migration PANC-1 cells wound healing, matrigel invasion, gelatin degradation assays. Apart from suppressing PI3K/Akt/NF-kB signaling, which is involved up-regulation matrix metalloproteinases, our...
The present work describes the synthesis, characterization, and anticancer properties of c(Lys-Pro), P1; c(Orn-Pro), P2; conjugates PA-c(Lys-Pro), C1; PA-c(Orn-Pro), C2; EPA-c(Lys-Pro), C3; EPA-c(Orn-Pro), C4. Among all, conjugate C4 displays potent activity with IC50 1.3 μM in MDA-MB-231, 3.5 PC-3, 8.9 MCF-7, 9.6 Miapaca-2 cancer cells. In addition, downregulates expression MDM2 abrogates cell invasion/metastasis. Through knock-down MDM2, we demonstrate that this abrogation metastasis by is...
The present work describes the synthesis and characterization of α/γ hybrid peptides, Boc‐Phe‐γ 4 ‐Phe‐Val‐OMe, P1 ; Boc‐Ala‐γ P2 Boc‐Leu‐γ P3 together with formation self‐assembled structures formed by these peptides in dimethyl sulfoxide (DMSO)/water (1:1). were characterized infrared (IR) spectroscopy, circular dichroism (CD), scanning electron microscopy (SEM). Further, peptide evaluated for antibacterial properties. Among all, exhibited antimicrobial activity against Escherichia coli...
Abstract Piperic acid (PA) and 4‐ethylpiperic (EPA) amides with non‐protein amino acids were synthesized bioevulated by using MTT [3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide] assay against a panel of three cancer cell lines i. e. human prostate (PC‐3), pancreatic (Panc‐1) colorectal carcinoma (HCT‐116) normal line BPH‐1. Among all the tested compounds, C3 exhibited promising cytotoxicity IC 50 7.0 μM it showed very mild cytotoxic effect on BPH‐1 cells. In addition, growth...
Abstract The present work describes the synthesis and crystallographic analysis of γα hybrid peptides, Boc‐γ 4 ‐L‐Phe‐L‐Pro‐NHMe ( P1 ) Boc‐(γ ‐L‐Phe‐L‐Pro) 2 ‐NHMe P2 ). Peptide adopts twelve membered (C 12 helical turn over segment, while folds into twisted ribbon structure involving two expanded C turns.
Abstract The present work describes the conformation of achiral α/β hybrid peptides, Boc‐Gly‐β 3,3 ‐Ac 6 c‐NHMe ( P1) , c‐Gly‐OMe P2 ), and c‐Gly‐β c‐OMe, P3 ) using X‐ray crystallography. Peptides P1 adopt C 11 12 folded conformations, respectively. directionality hydrogen bond observed in is opposite to that peptide . In case tetrapeptide no such observed. Further, solvent titration experiment establishes similar intramolecular bonding as crystals. amino group β c occupies equatorial...
The present work describes the synthesis, characterization, and wound healing properties of α/γ hybrid peptides: Boc-Phe-γ4 -Phe-Val-OMe (S1), Boc-D Phe-γ4 (S2), Boc-Ala-γ4 (S3), Ala-γ4 (S4), Boc-Leu-γ4 (S5), Leu-γ4 (S6). Peptides S1-S6 were screened against human keratinocytes (HaCaT) RAW 264.7 cells. Among all, S1- S2-treated cells exhibited high cell viability; S1 S2 induced keratinocyte migration inhibited production cytokines IL-6 TNF-α. In vivo results demonstrated that peptides...