A5071616841- Bioactive Compounds and Antitumor Agents
- Natural product bioactivities and synthesis
- Nuclear Receptors and Signaling
- Law in Society and Culture
- Pharmacological Effects of Natural Compounds
- Intellectual Property Law
- Phytochemistry and Biological Activities
- Bioactive natural compounds
- Circular RNAs in diseases
- Sesquiterpenes and Asteraceae Studies
- Synthesis and biological activity
- Human Rights and Development
- Protein Hydrolysis and Bioactive Peptides
- Insect Pest Control Strategies
- Dendrimers and Hyperbranched Polymers
- Advanced Aircraft Design and Technologies
- Herpesvirus Infections and Treatments
- Phytochemical and Pharmacological Studies
- Climate change impacts on agriculture
- Pancreatic and Hepatic Oncology Research
- Phytochemistry and Bioactivity Studies
- Phytochemicals and Medicinal Plants
- Ginger and Zingiberaceae research
- Hibiscus Plant Research Studies
- Cancer-related Molecular Pathways
Indian Institute of Integrative Medicine
2020-2024
Academy of Scientific and Innovative Research
2020-2024
Sandip Foundation
2023
Institute of Management Technology
2020
Bombay Veterinary College
2018-2020
Maharashtra Animal and Fishery Sciences University
2018
Obihiro University of Agriculture and Veterinary Medicine
2007-2009
In an endeavour to improve the anti-cancer activity of betulinic acid (BA), a series C-30 derivatives were envisaged and synthesized with novel synthetic approach. All evaluated for cytotoxic by MTT assay against six different human cancer cell lines: prostate (PC3), lung (A549), hepatocellular carcinoma (HepG2), leukemia (Molt-4), pancreatic (Panc-1) breast (MCF-7). The data revealed that compound 16 was observed most promising agent IC50 values 7.43 μM, 9.1 9.64 μM A549, MCF-7, PC3 lines...
Chronic wound healing is a major threat all over the world. There are currently plethora of biomaterials-based dressings available for applications. In this study, dual protein-based (silk fibroin and sericin) nanofibrous scaffold from natural source (B.mori silkworm cocoons) with antibacterial antioxidative properties was investigated. An electrospun layer-by-layer silk fabricated top layer hydrophobic protein blended polyvinyl alcohol (PVA), middle waste sericin loaded silver(I)...
The last decade has witnessed a substantial expansion in the field of microRNA (miRNA) biology, providing crucial insights into role miRNAs disease pathology, predominantly cancer progression and its metastatic spread. discovery tumor-suppressing represents potential approach for developing novel therapeutics. In this context, through miRNA microarray analysis, we examined consequences Prostate apoptosis response-4 (Par-4), well-established tumor-suppressor, stimulation on expression...
A redox-responsive macromolecular prodrug of tacrolimus, HA-ss-Tac, was constructed by conjugation tacrolimus (TAC, FK506) through its succinate ester to cystamine-modified hyaluronic acid (HA-Cys), and physicochemical properties immunosuppressive activity were studied. The synthesized HA-ss-TAC determined contain 8% chemically loaded TAC with significantly enhanced water solubility. release study showed a sustained drug slow degradation linker–drug bonds. In vitro inhibition proliferation...
Abstract JAK-STAT signalling pathway inhibitors have emerged as promising therapeutic agents for the treatment of hair loss. Among different JAK isoforms, JAK3 has become an ideal target drug discovery because it only regulates a narrow spectrum γc cytokines. Here, we report MJ04, novel and highly selective 3-pyrimidinylazaindole based inhibitor, potential growth promoter with IC 50 2.03 nM. During in vivo efficacy assays, topical application MJ04 on DHT-challenged AGA athymic nude mice...
Anogeissus pendula Edgew (Combretacae) is a traditional Indian medicinal plant with antiulcer, anti-inflammatory, anti-hepatoprotective and other pharmacological effects. A. commonly used by tribal groups to treat gastric disorders, this may be due phenolic compounds. The aim of study determine the antiulcer activity in pylorus ligated albino Wistar rats, biochemical function ulcer protection via various studies. was conducted on rats using ligation model. Ranitidine (20 mg/kg b.w) APHAE...
The present study describes the isolation, identification, and quantification of biomarker compounds in plant extracts Habenaria intermedia D. Don (Orchidaceae). isolation was carried out from H. by repeated column chromatography petroleum ether ethanol fractions extract tubers. These were characterized 1H 13C NMR mass spectral data. A new quantitative method established using high-performance liquid (HPLC)-PDA. As a result, seven isolated characterized. This is first report these this...
The current research effort focuses on dehydrozingerone (DHZ, 1), a secondary metabolite discovered in the rhizome of Zingiber officinale. Here, we designed and synthesized diaryl ether derivatives high yields (80–93%) using substituted arylboronic acids copper-promoted arylation phenol. For anti-microbial activity against clinically significant infectious strains Mycobacterium tuberculosis (ATCC 27294) H37Ra 25177), as well Gram-positive Gram-negative bacteria (B. subtilis ATCC 6633, E....
Abstract The present study explored the natural compound Isotelekin isolated from Inula racemose against anti‐inflammatory and immunomodulatory potential in LPS‐induced RAW264.7 cell lines immune‐elevated SRBC‐sensitized animal models. vitro studies, inhibited production of Th‐1 cytokines Interleukin‐6 (IL‐6), Tumour necrosis factor (TNF‐α), Interferon‐gamma (INF‐γ), increased Th‐2 Interleukin‐10 (IL‐10). Whereas it nitrites reactive oxygen species (ROS) by mitigating effect LPS...