A5030942664- Antimicrobial Peptides and Activities
- Corneal Surgery and Treatments
- Corneal surgery and disorders
- Polydiacetylene-based materials and applications
- Ocular Surface and Contact Lens
- Supramolecular Self-Assembly in Materials
- Herpesvirus Infections and Treatments
- Extracellular vesicles in disease
- Electrospun Nanofibers in Biomedical Applications
- RNA Interference and Gene Delivery
- Periodontal Regeneration and Treatments
- Ocular Disorders and Treatments
- Tissue Engineering and Regenerative Medicine
- Graphene and Nanomaterials Applications
- Antimicrobial agents and applications
- Immune Response and Inflammation
- Cardiac Structural Anomalies and Repair
Hôpital Maisonneuve-Rosemont
2020-2024
Université de Montréal
2020-2024
University of Ottawa
2023
Centre Hospitalier de l’Université de Montréal
2021-2022
Indian Institute of Technology Ropar
2018-2020
Bacterial infections pose a serious threat to mankind, and there is immense interest in the design development of self-assembled peptide gels using ultrashort peptides for antibacterial applications. The containing natural amino acids suffer from poor stability against proteolytic enzymes. Therefore, need develop with improved In present work, we report synthesis characterization α/γ hybrid Boc-D-Phe-γ4-L-Phe-PEA (NH007) Boc-L-Phe-γ4-L-Phe-PEA (NH009) improve stability. Both dipeptides were...
Introduction Corneal transplantation surgery faces several fundamental problems, including graft failure, especially in complicated cases, and a marked shortage of human donor corneas. The purpose this review is to examine developments biosynthetic alternatives corneal transplantation. In particular, we focus on the regulatory pathway considerations needed design an implant take it clinical application.Areas covered We define implants as those that combine synthetic natural components, well...
Severe HSV-1 infection can cause blindness due to tissue damage from severe inflammation. Due the high risk of graft failure in HSV-1-infected individuals, cornea transplantation restore vision is often contraindicated. We tested capacity for cell-free biosynthetic implants made recombinant human collagen type III and 2-methacryloyloxyethyl phosphorylcholine (RHCIII-MPC) suppress inflammation promote regeneration damaged corneas. To block viral reactivation, we incorporated silica dioxide...
Abstract Corneal HSV-1 infections are a leading cause of infectious blindness globally by triggering tissue damage due to the intense inflammation. treated mainly with antiviral drugs that clear but inefficient as prophylactics. The body produces innate cationic host defence peptides (cHDP), such cathelicidin LL37. Various epithelia, including corneal epithelium, express cHDPs can disintegration pathogen membranes, stimulate chemokine production, and attract immune cells. Here, we selected...
Spectacle correction for eyes with refractive errors is still the most widely used method, but very high-powered spectacle lenses, besides their unpleasing appearance, have inherent drawbacks of spherical and chromatic aberrations, prismatic effects, limitation visual fields.Contact lenses present own problems in form intolerance, allergy, irritation, conjunctival corneal lesions.Several workers attempted to change state eye by surgery.Barraquer (I949) Poyales (I950) resected a ring tissue...