A5042281465- Craniofacial Disorders and Treatments
- Cleft Lip and Palate Research
- Facial Trauma and Fracture Management
- Automotive and Human Injury Biomechanics
- Traumatic Brain Injury and Neurovascular Disturbances
- dental development and anomalies
- Traumatic Brain Injury Research
- Medical and Biological Sciences
- Injury Epidemiology and Prevention
- Head and Neck Surgical Oncology
- Cerebrospinal fluid and hydrocephalus
- Anatomy and Medical Technology
- Traumatic Ocular and Foreign Body Injuries
- Traffic and Road Safety
- Intracranial Aneurysms: Treatment and Complications
- Cardiac, Anesthesia and Surgical Outcomes
- Medical Imaging and Analysis
- Vascular Malformations Diagnosis and Treatment
- Spinal Fractures and Fixation Techniques
- Trauma and Emergency Care Studies
- Dental Radiography and Imaging
- Pain Management and Treatment
- Surgical Simulation and Training
- Pain Mechanisms and Treatments
- Neonatal and fetal brain pathology
Radboud University Nijmegen
2015-2024
Radboud University Medical Center
2014-2024
University Medical Center
2019
Université de Lille
2014
KU Leuven
2002-2013
The implementation of augmented reality (AR) in image-guided surgery (IGS) can improve surgical interventions by presenting the image data directly on patient at correct position and actual orientation. This approach resolve switching focus problem, which occurs conventional IGS systems when surgeon has to look away from operation field consult a 2-dimensional screen. Microsoft HoloLens, head-mounted AR display, was combined with an optical navigation system create AR-based system....
OBJECTIVE To compare minimally invasive endoscopic and open surgical procedures, to improve informed consent of parents, establish a baseline for further targeted improvement care, this study evaluated the complication rate blood transfusion craniosynostosis surgery in our department. METHODS A prospective registration database that contains consecutive cohort all pediatric neurosurgical procedures authors' department was used. All patients who underwent treatment between February 2004...
OBJECT Finite element models (FEMs) of the head are used to study biomechanics traumatic brain injury and depend heavily on use accurate material properties geometry. Any FEM aimed at investigating in children should therefore age-specific dimensions head, as well different tissues. In this study, authors built a database age-corrected skull geometry, thickness, bone density developing aid development an child’s head. Such database, containing normative geometry data, can also be for...
Neurocutaneous melanosis (NCM) is a rare congenital disorder characterized by the association of large and/or multiple melanocytic nevi (CMN) skin with lesions leptomeninges, including melanocytosis. Leptomeningeal melanocytosis carries poor prognosis once neurological symptoms develop. Despite surgery, which often not radical, few other treatment options exist. Recently, it was demonstrated that early embryonic, post-zygotic somatic mutations in NRAS gene are implicated pathogenesis NCM. In...
Abstract Craniosynostosis is a condition in which cranial sutures fuse prematurely, causing problems normal brain and skull growth infants. To limit the extent of cosmetic functional problems, swift diagnosis needed. The goal this study to investigate if deep learning algorithm capable correctly classifying head shape infants as either healthy controls, or one following three craniosynostosis subtypes; scaphocephaly, trigonocephaly anterior plagiocephaly. In order acquire data, 3D...
Mutations of the SOD1 gene underlie 1 form familial amyotrophic lateral sclerosis (ALS). Their pathogenic mechanism remains uncertain, but is thought to involve oxidative stress and abnormal protein aggregation, 2 processes known induce heat shock proteins (HSPs). We studied expression 3 HSPs (αB-crystallin, HSP27, HSP70) in transgenic mice overexpressing human mutant (G93A G37R) SOD1, using a combination immunohistochemistry immunoblotting. Quantitative Western blot analysis demonstrated...
The purpose of the present study was to investigate whether an energy failure level applies skull fracture mechanics in unembalmed post-mortem human heads under dynamic frontal loading conditions. A double-pendulum model used conduct impact tests on specimens from 18 subjects. were isolated at occipital condyle level, and pre-test computed tomography images obtained. rigidly attached aluminum pendulum upside down position obtained a single degree freedom, allowing motion plane impact. steel...
Finite element models (FEM) of the head are frequently used to simulate traumatic brain injury, leading a better understanding injury tolerance. The strength FEM is dependent on use correct material characteristics, experimentally derived for each intracranial tissue, including parasagittal bridging veins (BV). These prone rupture in their subdural portion upon impact, giving rise an acute hematoma (ASDH). junction these superior sagittal sinus (SSS) has been described as area with distinct...
Despite many efforts at reduction, cerebrospinal fluid (CSF) shunt infections are a major cause of morbidity in surgery, occurring 5-15% cases. To attempt to reduce the infection rate our institution, we added topical vancomycin (intrashunt and perishunt) existing prevention protocol 2012.We performed retrospective cohort study comparing all shunted patients January 2010 December 2011 without (control group, 263 procedures) who underwent surgery between April 2012 2015 with (intervention 499...
The surgeons' estimate of the extent resection (EOR) shows little accuracy in previous literature. Considering developments surgical techniques glioblastoma (GBM) treatment, we hypothesize an improvement this estimation. This study aims to compare EOR estimated by neurosurgeon with determined using volumetric analysis on post-operative MR scan. Pre- and tumor volumes were calculated through semi-automatic assessment three observers. Interobserver agreement was measured intraclass correlation...
OBJECTIVE Minimal literature exists on the intraoperative complication rate of pediatric neurosurgical procedures with respect to both surgical and anesthesiological complications. The aim this study, therefore, was establish rates provide patients parents information which base their informed consent a baseline for further targeted improvement care. METHODS A clinical registration database comprising consecutive cohort all carried out in general department from January 1, 2004, until July...
Reporting financial disclosures has become standard practice in both journal publications and during oral forum at scientific meetings. Despite this, the effect of reporting a disclosure any member an authorgroup, on tone conclusion article gained little attention. This study was performed to determine what article.A literature search for all articles interspinous devices cervical disc prostheses, published from January 1st, 2008 until December 2010 performed. Financial were reported, as...
OBJECTIVE After endoscopic third ventriculostomy (ETV), some patients develop recurrent symptoms of hydrocephalus. The optimal treatment for these is not clear: repeat ETV (re-ETV) or CSF shunting. goals the study were to assess effectiveness re-ETV relative initial in pediatric and validate success score (ETVSS) re-ETV. METHODS Retrospective data 624 93 procedures collected from 6 neurosurgical centers Netherlands (1998-2015). Multivariable Cox proportional hazards modeling was used provide...
Summary Background: This retrospective cohort study evaluated the longitudinal three-dimensional (3D) cranial shape developments and secondary treatment aspects after endoscopically assisted craniosynostosis surgery (EACS) with helmet therapy open vault reconstruction (OCVR) for scaphocephaly. Methods: Longitudinally collected 3D photos from scaphocephaly patients healthy infants were evaluated. measurements growth maps compared between groups over time. Secondary groups. Results: Both...