A5030572152- Schizophrenia research and treatment
- Child and Adolescent Psychosocial and Emotional Development
- Suicide and Self-Harm Studies
- Genetics and Neurodevelopmental Disorders
- Autism Spectrum Disorder Research
- COVID-19 Impact on Reproduction
- Neuroscience and Music Perception
- Cardiac electrophysiology and arrhythmias
- Bipolar Disorder and Treatment
- Medical Imaging and Pathology Studies
- Ion Transport and Channel Regulation
- Psychological and Educational Research Studies
- Migration, Health and Trauma
- Genetic Neurodegenerative Diseases
- Adolescent and Pediatric Healthcare
- Pediatric Pain Management Techniques
- Infant Development and Preterm Care
- Neuroendocrine regulation and behavior
- Ion channel regulation and function
- Signaling Pathways in Disease
- COVID-19 and Mental Health
- Advanced Neuroimaging Techniques and Applications
- Innovative Teaching Methods
- Homelessness and Social Issues
- Genomic variations and chromosomal abnormalities
Stanford Health Care
2023
Stanford University
2018-2021
Boston Children's Hospital
2015-2019
Harvard University
2016-2018
Boston Children's Museum
2018
The COVID-19 pandemic threatens global newborn health. We describe the current state of national and local protocols for managing neonates born to SARS-CoV-2-positive mothers. Care providers from neonatal intensive care units on six continents exchanged compared management Data collection was between March 14 21, 2020. focused central protocol components, including triaging, hygiene precautions, at delivery, feeding protocols, visiting policies. 20 countries were available. Disease burden...
We describe a child with onset of command auditory hallucinations and behavioral regression at 6 yr age in the context longer standing selective mutism, aggression, mild motor delays. His genetic evaluation included chromosomal microarray analysis whole-exome sequencing. Sequencing revealed previously unreported heterozygous de novo mutation c.385G>A ATP1A3, predicted to result p.V129M amino acid change. This gene codes for neuron-specific isoform catalytic α-subunit ATP-dependent...
Abstract Objective To evaluate COVID-19 pandemic preparedness, available resources, and guidelines for neonatal care delivery among health providers in low- middle-income countries (LMICs) across all continents. Study design Cross-sectional, web-based survey administered between May June, 2020. Results Of 189 invited participants 69 LMICs, we received 145 (77%) responses from 58 (84%) countries. The provides significant challenges to care, particularly low-income Respondents noted...
Early life adversity leads to enduring effects on physical and mental health, school performance other outcomes. We sought identify potentially modifiable factors associated with socioeconomic in early life.We enrolled 1503 pregnant women aged 16-40 years, without pregnancy complications or pre-existing conditions from Shelby County, Tennessee. Social, familial economic variables were analysed using principal components (PCs) analyses generate the Socioeconomic Adversity Index (SAI). This...
Copy number variability at 16p13.11 has been associated with intellectual disability, autism, schizophrenia, epilepsy, and attention‐deficit hyperactivity disorder. Adolescent/adult‐ onset psychosis reported in a subset of these cases. Here, we report on two children CNVs that developed before the age 7. The genotype neuropsychiatric abnormalities patients highlight several overlapping genes have possible mechanistic relevance to pathways previously implicated Autism Spectrum Disorders,...
Complex phenotypes may represent novel syndromes that are the composite interaction of several genetic and environmental factors. We describe an 9-year old male with high functioning autism spectrum disorder Muckle-Wells syndrome who at age 5 years manifested perseverations interfered his home school. After 6, he developed intermittent episodes fatigue somnolence lasting from hours to weeks evolved over course months more chronic hypersomnia. Whole exome sequencing showed three mutations in...
TRRAP encodes a multidomain protein kinase that works as genetic cofactor to influence DNA methylation patterns, damage repair, and chromatin remodeling. is vital early neural developmental processes, variants in this gene have been associated with schizophrenia childhood disintegrative disorder. Here, we report on patient de novo nonsynonymous single-nucleotide variant (EST00000355540.3:c.5957G > A, p.Arg1986Gln) onset major depression accompanied by psychotic episode (before age 10)...
Highly penetrant mutations leading to schizophrenia are enriched for genes coding N-methyl-D-aspartate receptor signaling complex (NMDAR-SC), implicating plasticity defects in the disease’s pathogenesis. The importance of neurodevelopment implies a role therapies that target these mechanisms early life prevent schizophrenia. Testing such requires noninvasive methods can assess engagement mechanisms. auditory N100 is an obligatory cortical response whose amplitude decreases with tone...
Aim Previous research has demonstrated a strong association between early trauma exposure and the development of psychotic symptoms. However, few these studies have included young adolescents children. This study investigated rates number potentially traumatic experiences (PTEs) among typically developing youth (TD; n = 21), at clinical high risk for psychosis (CHR; 38), with disorder (PD; 28) 7 18 years age. CHR participants were further evaluated to determine whether history PTEs was...
Suicidal thoughts and behaviors (STBs) are prevalent among youth with psychotic disorders (PD) relative to the general population. Recent research now suggests that STBs may present during prodromal phase of disease, or clinical high risk (CHR) state. While this knowledge is important for development suicide prevention strategies in adolescent adult populations, it remains unclear whether extends children at psychosis. The current study an extension previous work assessing across psychosis...
This article has been withdrawn at the request of authors(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. full title removed because it contains two rare conditions that identify patient. Elsevier Policy on Article Withdrawal can be found http://www.elsevier.com/locate/withdrawalpolicy.
We describe a project-based learning (PBL) program that combines student-driven projects with year-long mentorship to inspire high school students pursue science, technology, engineering, and math (STEM). Previous studies indicate PBL improves outcomes, teamwork, long-term interest (1–4). Separate work suggests (LTM) programs can promote pipeline into higher education STEM for from underrepresented backgrounds (5, 6).We sought combine LTM through single called Future Advancers of Science...