A5033307839- Molecular Sensors and Ion Detection
- Alzheimer's disease research and treatments
- Cholinesterase and Neurodegenerative Diseases
- Computational Drug Discovery Methods
- Polymer crystallization and properties
- Rheology and Fluid Dynamics Studies
- Polymer Nanocomposites and Properties
- Advanced biosensing and bioanalysis techniques
- Luminescence and Fluorescent Materials
- Analytical Chemistry and Sensors
- Photochromic and Fluorescence Chemistry
- Radical Photochemical Reactions
- Free Radicals and Antioxidants
- Trace Elements in Health
- Machine Learning in Materials Science
- Advanced Malware Detection Techniques
- Hydrogels: synthesis, properties, applications
- Click Chemistry and Applications
- Prion Diseases and Protein Misfolding
- Supramolecular Self-Assembly in Materials
- Polymer Foaming and Composites
- Polymer composites and self-healing
- RNA modifications and cancer
- Enzyme Structure and Function
- Analytical Chemistry and Chromatography
Korea Research Institute of Chemical Technology
2022-2025
Korea Advanced Institute of Science and Technology
2018-2025
Pusan National University
2016-2023
Electronics and Telecommunications Research Institute
2021
Ulsan National Institute of Science and Technology
2017-2019
Daejeon University
2019
One approach to assess the security of embedded IoT devices is applying dynamic analysis such as fuzz testing their firmware in scale. To this end, existing approaches aim provide an emulation environment that mimics behavior real hardware/peripherals. Nonetheless, practice, can emulate only a small fraction images. For example, Firmadyne, state-of-the-art tool, run 183 (16.28%) 1,124 wireless router/IP-camera images we collected from top eight manufacturers. Such low success rate caused by...
Metal–BODIPY complexes, rationally designed as photosensitizers, can effectively oxidize amyloidogenic peptides upon photoactivation at a relatively longer wavelength, resulting in altering their aggregation profiles.
The effects of various Cloisite nanoparticulate clays with different hydrophobicities on (80/20) polypropylene/polystyrene (PP/PS) blends were investigated using their linear and nonlinear rheological properties. In descending order hydrophobicity the four examined C20A > C10A C30B CNa+. Clays a wetting coefficient ωa between 1 −1, that is C10A, located at PP/PS polymer interfaces suppressed coalescence, while >1, CNa+, accumulated inside PS droplets increased viscosity ratios. As result,...
The effects of Cloisite nanoparticulate clays on the morphologies three biodegradable polymer blends, that is, poly(lactic acid) (PLA)/poly(ε-caprolactone) (PCL), PLA/poly(butylene adipate-co-terephthalate) (PBAT), and succinate-co-adipate) (PBSA), were investigated by linear nonlinear rheological analysis. All PLA/PCL, PLA/PBAT, PLA/PBSA, blended at a ratio 80/20 wt %. Three different clays, C20A, C30B, CNa+, used as compatibilizers. Two organically modified C30B located interfaces between...
As a central feature of neuroinflammation, microglial dysfunction has been increasingly considered causative factor neurodegeneration implicating an intertwined pathology with amyloidogenic proteins. Herein, we report the smallest synthetic molecule ( N , ′-diacetyl- p -phenylenediamine [DAPPD]), simply composed benzene ring 2 acetamide groups at para position, known to date as chemical reagent that is able promote phagocytic aptitude microglia and subsequently ameliorate cognitive defects....
The deposition of amyloid-β (Aβ) aggregates and metal ions within senile plaques is a hallmark Alzheimer's disease (AD). Among the modifications observed in Aβ peptides, N-terminal truncation at Phe4, yielding Aβ4–x, highly prevalent AD-affected brains significantly alters Aβ's metal-binding aggregation profiles. Despite abundance Zn(II) plaques, its impact on toxicity Aβ4–x remains unexplored. Here, we report distinct behavior N-terminally truncated Aβ, specifically Aβ4–42, absence presence...
Abstract The fabrication of liquid crystalline (LC) organogel via supramolecular interactions between Deoxyribonucleic acid (DNA) and lyotropic cationic surfactant containing cyanobiphenyl moiety is reported. fabricated endows dominantly viscous behavior in dimethyl sulfoxide (DMSO) elastic n‐propanol (n‐PrOH), respectively. By judiciously controlling the viscosity, DMSO organogels can be drawn to form a fiber with an elongation up 4.6 × 10 3 %, emphasizing extraordinary stretchability....
Multiple pathogenic elements, including reactive oxygen species, amyloidogenic proteins, and metal ions, are associated with the development of neurodegenerative disorders. We report minimalistic redox-based principles for preparing compact aromatic compounds by derivatizing phenylene moiety various functional groups. These molecular agents display enhanced reactivities against multiple targets such as free radicals, metal-free amyloid-β (Aβ), metal-bound Aβ that implicated in most common...
Developing chemical methodologies to directly modify harmful biomolecules affords the mitigation of their toxicity by persistent changes in properties and structures. Here we report compact photosensitizers composed anthraquinone (AQ) backbone that undergo excited-state intramolecular hydrogen transfer, effectively oxidize amyloidogenic peptides, and, subsequently, alter aggregation pathways. Density functional theory calculations showed appropriate position hydroxyl groups AQ consequent...
DNA is an anisotropic, water-attracting, and biocompatible material, ideal building block for hydrogel. The alignment of the anisotropic chains essential to maximize hydrogel properties, which has been little explored. Here, we present a method fabricate that allows precise control polymerization process photoreactive cationic monomers. Scanning ultraviolet light enables uniaxial through polymerization-induced diffusive mass flow using concentration gradient. While studying mechanical...
To achieve efficient heat dissipation using polymer composites, it is important to optimize the conduction pathway. Therefore, manipulating orientation of thermally conductive and anisotropic fillers in composites represents a judicious strategy. So far, external fields have been applied align within matrix. However, these processes are energy-intensive require stimuli-responsive through surface modification, further complicating process deteriorating filler thermal conductivity. Herein,...
The underlying causes of Alzheimer's disease (AD) remain a mystery, with multiple pathological components, including oxidative stress, acetylcholinesterase, amyloid-β, and metal ions, all playing role. Here we report strategic approach to designing flavonoids that can effectively tackle elements involved in AD. Our systematic investigations revealed key structural features for simultaneously target regulate pathogenic targets. findings led the development highly promising flavonoid exhibits...
Characterizing dispersion quality of polymer nanocomposite (PNC) is as important dispersing nanosized fillers in the matrix. In this study, to quantify PNCs, we used rheological properties, that is, linear viscoelasticities determined by small-amplitude oscillatory shear tests and nonlinear large-amplitude tests. Nonlinear were analyzed with Fourier transform (FT)-rheology. Two different disperse-controlled PNCs investigated. One a polypropylene (PP)/clay system compatibilized using maleic...
We report orobol as a multifunctional isoflavone with the ability to (i) modulate aggregation pathways of both metal-free and metal-bound amyloid-β, (ii) interact metal ions, (iii) scavenge free radicals, (iv) inhibit activity acetylcholinesterase. Such framework multifunctionality could be useful for developing chemical reagents advance our understanding multifaceted pathologies neurodegenerative disorders, including Alzheimer's disease.
A novel fluorescent turn-on chemosensor
Chemical tools have been valuable for establishing a better understanding of the relationships between metal ion dyshomeostasis, abnormal aggregation and accumulation amyloid-β (Aβ), oxidative stress in Alzheimer's disease (AD). Still, very little information is available to correlate structures chemical with specific reactivities used uncover such relationships. Recently, slight structural variations framework tool were found drastically determine tool's toward multiple pathological facets...