A5027470004- Alzheimer's disease research and treatments
- Computational Drug Discovery Methods
- Cholinesterase and Neurodegenerative Diseases
- Trace Elements in Health
- Liquid Crystal Research Advancements
- Molecular Sensors and Ion Detection
- Protease and Inhibitor Mechanisms
- Free Radicals and Antioxidants
- Metal complexes synthesis and properties
- Peptidase Inhibition and Analysis
- Photonic Crystals and Applications
- Metal-Organic Frameworks: Synthesis and Applications
- Phytoestrogen effects and research
- Drug Transport and Resistance Mechanisms
- Plant Reproductive Biology
- Histone Deacetylase Inhibitors Research
- Electrochemical Analysis and Applications
- Machine Learning in Materials Science
- Bioinformatics and Genomic Networks
- Cholesterol and Lipid Metabolism
- Nitric Oxide and Endothelin Effects
- Amyotrophic Lateral Sclerosis Research
- Inflammatory mediators and NSAID effects
- Enzyme function and inhibition
- E-commerce and Technology Innovations
Gongju National University of Education
2019-2025
Kongju National University
2019-2025
Korea Advanced Institute of Science and Technology
2018-2020
Gongju National Hospital
2020
Government of the Republic of Korea
2015-2020
Daejeon University
2018-2019
Ulsan National Institute of Science and Technology
2014-2017
University of Michigan
2013-2016
Samsung (South Korea)
2011-2015
Ulsan College
2015
Alzheimer's disease (AD) is characterized by multiple, intertwined pathological features, including amyloid-β (Aβ) aggregation, metal ion dyshomeostasis, and oxidative stress. We report a novel compound (ML) prototype of rationally designed molecule obtained integrating structural elements for Aβ aggregation control, chelation, reactive oxygen species (ROS) regulation, antioxidant activity within single molecule. Chemical, biochemical, mobility mass spectrometric, NMR studies indicate that...
Cancers are currently the major cause of mortality in world. According to previous studies, matrix metalloproteinases (MMPs) have an impact on tumor cell proliferation, which could lead onset and progression cancers. Therefore, regulating expression activity MMPs, especially MMP-2 MMP-9, be a promising strategy reduce risk Various studies tried investigate understand pathophysiology cancers suggest potent treatments. In this review, we summarize how natural products from marine organisms...
Glaucoma encompasses a group of optic neuropathies characterized by complex and often elusive etiopathology, involvihttng neurodegeneration the nerve in conjunction with abnormal intraocular pressure (IOP). Currently, there is no cure for glaucoma, treatment strategies primarily aim to halt disease progression managing IOP. This review delves into diagnostic methods, approaches special focus on IOP management. We discuss range active pharmaceutical ingredients used glaucoma therapy,...
Regulation of amyloid-β (Aβ) aggregation by metal ions and proteins is essential for understanding the pathology Alzheimer's disease (AD). Human serum albumin (HSA), a regulator protein transportation, can modulate metal-Aβ interactions Aβ in human fluid; however, molecular mechanisms such activities remain unclear. Herein, we report molecular-level complexation between Zn(II), Cu(II), Aβ, HSA, which able to alter cytotoxicity peptides induce their cellular transportation. In addition,...
Chemical reagents targeting and controlling amyloidogenic peptides have received much attention for helping identify their roles in the pathogenesis of protein-misfolding disorders. Herein, we report a novel strategy redirecting into nontoxic, off-pathway aggregates, which utilizes redox properties small molecule (DMPD, N,N-dimethyl-p-phenylenediamine) to trigger covalent adduct formation with peptide. In addition, first time, biochemical, biophysical, molecular dynamics simulation studies...
An <italic>in vivo</italic> chemical tool designed to target metal−Aβ complexes and modulate their activity was applied the 5XFAD mouse model of Alzheimer’s disease (AD) demonstrating involvement in AD pathology.
Aminoisoflavones were shown to interact and react with metal-free metal-associated amyloid-β different extents.
Surface pinning effect of the optically isotropic, blue phase liquid crystal (BPLC) has been studied. Polycrystalline, platelet, multi-domain topological defects without surface treatment have transformed to uniform monodomain in rubbed surfaces cell. The operating voltage was reduced by 27%, owing a dramatic increase Kerr constant. Hysteresis 63%, whereas transmission efficiency gets doubled. anchoring on plays significant role elastic free energy, coherence length and defects. BPLC...
A small molecule was designed for reactivity toward Cu(<sc>ii</sc>)–amyloid-β over Zn(<sc>ii</sc>)–amyloid-β, which will expand on the development of chemical tools to uncover role metal–Aβ species in Alzheimer's disease.
Abstract Aggregates of amyloidogenic peptides are involved in the pathogenesis several degenerative disorders. Herein, an iridium(III) complex, Ir‐1 , is reported as a chemical tool for oxidizing upon photoactivation and subsequently modulating their aggregation pathways. was rationally designed based on multiple characteristics, including 1) photoproperties leading to excitation by low‐energy radiation; 2) generation reactive oxygen species responsible peptide oxidation under mild...
Amyloidosis is a clinical disorder implicated with the formation of toxic amyloid aggregates. Despite their pathological significance, it challenging to define structural characteristics oligomers owing metastable nature. Herein, we report and mechanistic investigations human islet polypeptide (hIAPP) oligomers, found in type II diabetes mellitus, both absence presence disease-relevant metal ions [i.e., Cu(ii) Zn(ii)]. These show suppressive effects on hIAPP fibrillation facilitate...
The structural features of flavonoids responsible for their versatile reactivities against four pathogenic elements Alzheimer's disease were identified.
Multiple pathogenic elements, including reactive oxygen species, amyloidogenic proteins, and metal ions, are associated with the development of neurodegenerative disorders. We report minimalistic redox-based principles for preparing compact aromatic compounds by derivatizing phenylene moiety various functional groups. These molecular agents display enhanced reactivities against multiple targets such as free radicals, metal-free amyloid-β (Aβ), metal-bound Aβ that implicated in most common...
When Alzheimer's disease (AD) progresses, several pathological features arise including accumulation of misfolded protein aggregates [e.g., amyloid-β (Aβ) plaques], metal ion dyshomeostasis, and oxidative stress. These characteristics are recently suggested to be interconnected through a potential factor, metal-associated Aβ (metal-Aβ) species. The role metal-Aβ species in AD pathogenesis remains unclear, however. To elucidate the contribution pathology, as well develop small molecules...
Structural variations of a flavonoid framework noticeably tune the interaction and reactivity flavonoids with metals, Aβ, metal–Aβ.
Effective chemical strategies, <italic>i.e.</italic>, coordination and coordination-/photo-mediated oxidation, are rationally developed towards modification of amyloidogenic peptides subsequent control their aggregation toxicity.
Significance Metal ions in the brain exhibit both functional (e.g., signal transduction, oxidative metabolism, and antioxidant defense) pathological qualities damage). Impaired metal ion homeostasis is linked to decrease enzymatic activities, elevation of protein aggregation, stress, leading neurodegeneration. Particularly, copper coordinates amyloid-β (Aβ) peptides, a factor Alzheimer’s disease, facilitating Aβ aggregation inducing stress. Our work presents mechanistic strategy modify...
Multiple pathogenic factors [e.g., amyloid-β (Aβ), metal ions, metal-bound Aβ (metal–Aβ), reactive oxygen species (ROS)] are found in the brain of patients with Alzheimer's disease (AD). In order to elucidate roles pathological elements AD, chemical tools able regulate their activities would be valuable. Due complicated link among multiple factors, however, it has been challenging invent such tools. Herein, we report novel small molecules as toward modulation single or target(s), designed...